Detection and Identification of Novel Metabolomic Biomarkers in Preeclampsia
Tóm tắt
Từ khóa
Tài liệu tham khảo
Confidential Enquiry into Stillbirths and Deaths in Infancy (CESDI). Fifth Annual Report. Maternal and Child Health Research Consortium; 1998.
Barker DJ, Gluckman PD, Godfrey KM, et al. Fetal nutrition and cardiovascular disease in adult life. Lancet. 1993;341:938–941.
Hayman R, Brockelsby J, Kenny L, Baker P. Preeclampsia: the endothelium, circulating factor(s) and vascular endothelial growth factor. J Soc Gynecol Investig. 1999;6:3–10.
Pijnenborg R, Anthony J, Davey DA, et al. Placental bed spiral arteries in the hypertensive disorders of pregnancy. Br J Obstet Gynaecol. 1991;98:648–655.
Kenny LC, Baker PN, Kendall DA, Randall MD, Dunn WR. Differential mechanisms of endothelium-dependent vasodilator responses in human myometrial small arteries in normal pregnancy and pre-eclampsia. Clin Sci (Lond). 2002;103:67–73.
Roberts JM, Taylor RN, Musci TJ, Rodgers GM, Hubel CA, McLaughlin MK. Preeclampsia: an endothelial cell disorder. Am J Obstet Gynecol. 1989;161:1200–1204.
Rodgers GM, Taylor RN, Roberts JM. Preeclampsia is associated with a serum factor cytotoxic to human endothelial cells. Am J Obstet Gynecol. 1988;159:908–914.
Kell DB. Systems biology, metabolic modelling and metabolomics in drug discovery and development. Drug Discov Today. 2006;11:1085–1092.
Raamsdonk LM, Teusink B, Broadhurst D, et al. A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations. Nat Biotechnol. 2001;19:45–50.
Kenny LC, Dunn WB, Ellis DI, et al. Novel biomarkers for pre-eclampsia detected using metabolomics and machine learning. Metabolomics. 2005;1:227–234.
Broadhurst D, Kell DB. Statistical strategies for avoiding false discoveries in metabolomics and related experiments. Metabolomics. 2006;2:171–196.
Davey DA, MacGillivray I. The classification and definition of the hypertensive disorders of pregnancy. In: Hypertension in Pregnancy: the Proceedings of the 16th Study Group of the Royal College of Obstetricians and Gynaecologists. London, UK: RCOG; 1986:401–407.
Gopec Consortium. Disentangling fetal and maternal susceptibility for pre-eclampsia: a British multicenter candidate-gene study. Am J Hum Genet. 2005;77:127–131.
Hu Q, Noll RJ, Li H, Makarov A, Hardman M, Graham Cooks R. The Orbitrap: a new mass spectrometer. J Mass Spectrom. 2005;40:430–443.
Makarov A, Denisov E, Kholomeev A, et al. Performance evaluation of a hybrid linear ion trap/Orbitrap mass spectrometer. Anal Chem. 2006;78:2113–2120.
Kind T, Fiehn O. Seven golden rules for heuristic filtering of molecular formulas obtained by accurate mass spectrometry. BMC Bioinformatics. 2007;8:105.
Friedrich T, Roth M, Helm-Kruse S, Jeltsch A. Functional mapping of the EcoRV DNA methyltransferase by random mutagenesis and screening for catalytically inactive mutants. Biol Chem. 1998;379:475–480.
Hollander M, Wolfe DA. Nonparametric Statistical Methods. New York, NY: Wiley; 1973.
Kell DB, Oliver SG. Here is the evidence, now what is the hypothesis? The complementary roles of inductive and hypothesis-driven science in the post-genomic era. Bioessays. 2004;26:99–105.
Dunn WB, Broadhurst DI, Sasalu D, et al. Serum metabolomics reveals many novel metabolic markers of heart failure, including pseudouridine and 2-oxoglutarate. Metabolomics. In press.
Sabatine MS, Liu E, Morrow DA, et al. Metabolomic identification of novel biomarkers of myocardial ischemia. Circulation. 2005;112:3868–3875.
Borzychowski AM, Sargent IL, Redman CW. Inflammation and pre-eclampsia. Semin Fetal Neonatal Med. 2006;11:309–316.
Hubel CA. Oxidative stress in the pathogenesis of preeclampsia. Proc Soc Exp Biol Med. 1999;222:222–235.
Redman CW, Sargent IL. Placental debris, oxidative stress and pre-eclampsia. Placenta. 2000;21:597–602.
Redman CW, Sargent IL. Pre-eclampsia, the placenta and the maternal systemic inflammatory response-a review. Placenta. 2003;24(suppl A):S21–S27.
Sargent IL, Borzychowski AM, Redman CW. NK cells and human pregnancy-an inflammatory view. Trends Immunol. 2006;27:399–404.
Sharma JB, Sharma A, Bahadur A, Vimala N, Satyam A, Mittal S. Oxidative stress markers and antioxidant levels in normal pregnancy and pre-eclampsia. Int J Gynecol Obstet. 2006;94: 23–27.
Duarte NC, Becker SA, Jamshidi N, et al. Global reconstruction of the human metabolic network based on genomic and bibliomic data. Proc Natl Acad Sci USA. 2007;104:1777–1782.