Designing and Maintaining the Mature TCR Repertoire

Ashton-Rickardt, 1993, Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus, Cell, 73, 1041, 10.1016/0092-8674(93)90281-T

Bevan, 1997, In thymic selection, peptide diversity gives and takes away, Immunity, 7, 175, 10.1016/S1074-7613(00)80520-8

Bikoff, 1993, Defective MHC complex class II assembly, transport, peptide acquisition and CD4+ T cell selection in mice lacking invariant chain expression, J. Exp. Med, 177, 1699, 10.1084/jem.177.6.1699

Brocker, 1997, Survival of mature CD4 T lymphocytes is dependent on MHC class II-expressing dendritic cells, J. Exp. Med, 186, 1223, 10.1084/jem.186.8.1223

Bruno, 1995, On the cellular basis of immunological T cell memory, Immunity, 2, 37, 10.1016/1074-7613(95)90077-2

Burkly, 1995, Expression of relB is required for the development of thymic medulla and dendritic cells, Nature, 373, 531, 10.1038/373531a0

Chervonsky, 1998, Subtle conformational changes induced in major histocompatibility complex class II molecules by binding peptides, Proc. Natl. Acad. Sci. USA, 95, 10094, 10.1073/pnas.95.17.10094

DeKoning, 1997, Thymic cortical epithelium is sufficient for the development of mature T cells in relB-deficient mice, J. Immunol, 158, 2558, 10.4049/jimmunol.158.6.2558

Denzin, 1995, HLA-DM induces CLIP dissociation from MHC class II αβ dimers and facilitates peptide loading, Cell, 82, 155, 10.1016/0092-8674(95)90061-6

Ernst, 1995, Thymic selection and cell division, J. Exp. Med, 182, 961, 10.1084/jem.182.4.961

Fung-Leung, 1996, Antigen presentation and T cell development in H2-M deficient mice, Science, 271, 1278, 10.1126/science.271.5253.1278

Grubin, 1997, Deficient positive selection of CD4+ T cells in mice displaying altered repertoire of MHC class II bound self-peptides, Immunity, 7, 197, 10.1016/S1074-7613(00)80523-3

Grusby, 1991, Depletion of CD4+ T cells in major histocompatibility complex class II deficient mice, Science, 253, 1417, 10.1126/science.1910207

Hogquist, 1993, Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture, J. Exp. Med, 177, 1469, 10.1084/jem.177.5.1469

Hunt, 1992, Peptides presented to the immune system by the murine class II major histocompatibility complex molecule I-Ad, Science, 256, 1817, 10.1126/science.1319610

Ignatowicz, 1996, The repertoire of T cells shaped by a single MHC/peptide ligand, Cell, 84, 521, 10.1016/S0092-8674(00)81028-4

Jameson, 1995, Positive selection of thymocytes, Annu. Rev. Immunol, 13, 93, 10.1146/annurev.iy.13.040195.000521

Janeway, 1984, Monoclonal antibodies specific for Ia glycoproteins raised by immunization with activated T cells, J. Immunol, 132, 662, 10.4049/jimmunol.132.2.662

Janeway, 1998, T cell development, survival and signaling, Immunologist, 6, 5

Kirberg, 1997, Peripheral T cell survival requires continual ligation of the T cell receptor to MHC-encoded molecules, J. Exp. Med, 186, 1269, 10.1084/jem.186.8.1269

Kisielow, 1995, Development and selection of T cells, Adv. Immunol, 58, 87, 10.1016/S0065-2776(08)60620-3

Lam, 1997, In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death, Cell, 90, 1073, 10.1016/S0092-8674(00)80373-6

Lyons, 1994, Determination of lymphocyte division by flow cytometry, J. Immunol. Methods, 171, 131, 10.1016/0022-1759(94)90236-4

Martin, 1996, H-2M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection, Cell, 84, 543, 10.1016/S0092-8674(00)81030-2

Miyazaki, 1996, Mice lacking H2-M complexes, enigmatic elements of the MHC class Ii peptide loading pathway, Cell, 84, 531, 10.1016/S0092-8674(00)81029-6

Murphy, 1989, A novel MHC class II epitope expressed in thymic medulla but not cortex, Nature, 338, 765, 10.1038/338765a0

Murphy, 1992, Monoclonal antibody detection of a major self peptide. MHC class II complex, J. Immunol, 148, 3483, 10.4049/jimmunol.148.11.3483

Neuberger, 1997, Antigen receptor signaling gives lymphocytes a long life, Cell, 90, 971, 10.1016/S0092-8674(00)80362-1

Nikolic-Zugic, 1990, Role of self-peptides in positively selecting the T cell receptor repertoire, Nature, 344, 65, 10.1038/344065a0

Nossal, 1994, Negative selection of lymphocytes, Cell, 76, 229, 10.1016/0092-8674(94)90331-X

Ozato, 1980, Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens, J. Immunol, 124, 533, 10.4049/jimmunol.124.2.533

Penit, 1997, Expansion of mature thymocytes subsets before emigration to the periphery, J. Immunol, 159, 4848, 10.4049/jimmunol.159.10.4848

Riberdy, 1992, HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides, Nature, 353, 660

Robey, 1994, Selective events in T cell development, Annu. Rev. Immunol, 12, 675, 10.1146/annurev.iy.12.040194.003331

Rocha, 1991, Peripheral selection of the T cell repertoire, Science, 251, 1225, 10.1126/science.1900951

Rooke, 1997, Targeted complementation of MHC class II deficiency by intrathymic delivery of recombinant adenovirus, Immunity, 7, 123, 10.1016/S1074-7613(00)80515-4

Rudensky, 1991, On the complexity of self, Nature, 353, 660, 10.1038/353660a0

Rudensky, 1991, Sequence analysis of peptides bound to MHC class II molecules, Nature, 353, 622, 10.1038/353622a0

Sant’Angelo, 1997, The imprint of intrathymic self-peptides on the mature T cell receptor repertoire, Immunity, 7, 517, 10.1016/S1074-7613(00)80373-8

Sette, 1992, Invariant chain peptides in most HLA-DR molecules of an antigen-processing mutant, Science, 258, 1801, 10.1126/science.1465617

Sha, 1990, Positive selection of transgenic receptor-bearing thymocytes by Kb antigen is altered by Kb mutations that involve peptide binding, Proc. Natl. Acad. Sci. USA, 87, 6186, 10.1073/pnas.87.16.6186

Sprent, 1991, Mature murine B and T cells transferred to SCID mice can survive indefinitely and many maintain a virgin phenotype, J. Exp. Med, 174, 717, 10.1084/jem.174.3.717

Steinman, 1997, Dendritic cells in the T cell areas of lymphoid organs, Immunol. Rev, 156, 25, 10.1111/j.1600-065X.1997.tb00956.x

Surh, 1997, Thymic selection by a single MHC/peptide ligand produces a semidiverse repertoire of CD4+ T cells, Immunity, 7, 209, 10.1016/S1074-7613(00)80524-5

Takeda, 1996, MHC class II molecules are not required for survival of newly generated CD4+ T cells but affect their long-term life span, Immunity, 5, 217, 10.1016/S1074-7613(00)80317-9

Tanchot, 1995, The peripheral T cell repertoire, Eur. J. Immunol, 25, 2127, 10.1002/eji.1830250802

Tanchot, 1997, Peripheral selection of T cell repertoires, J. Exp. Med, 7, 1099, 10.1084/jem.186.7.1099

Tanchot, 1997, Differential requirements for survival and proliferation of CD8 naive or memory T cells, Science, 276, 2057, 10.1126/science.276.5321.2057

Tough, 1994, Turnover of naive- and memory-phenotype T cells, J. Exp. Med, 179, 1127, 10.1084/jem.179.4.1127

Tourne, 1997, Selection of a broad repertoire of CD4+ T cells in mice H-2Mαo/o mice, Immunity, 7, 187, 10.1016/S1074-7613(00)80522-1

Viret, 1999, MHC and T cell development, Rev. Immunogenet, 1

von Boehmer, 1994, Positive selection of lymphocytes, Cell, 76, 219, 10.1016/0092-8674(94)90330-1

von Boehmer, 1993, The lifespan of naive a/b T cells in secondary lymphoid organs, J. Exp. Med, 177, 891, 10.1084/jem.177.4.891

Webb, 1990, Extrathymic tolerance of mature T cells, Cell, 63, 1249, 10.1016/0092-8674(90)90420-J

Zijlstra, 1990, β2-microglobulin deficient mice lack CD4-CD8+ cytolytic T cells, Nature, 344, 742, 10.1038/344742a0