Design, synthesis and anticancer activity of furochromone and benzofuran derivatives targeting VEGFR-2 tyrosine kinase

RSC Advances - Tập 5 Số 32 - Trang 25312-25324
Omaima M. Abdelhafez1,2,3, Hamed I. Ali4,5,6,7, Kamelia M. Amin8,2,9,10, Mohamed M. Abdalla2,11,12, Eman Y. Ahmed1,2,3
1Chemistry of Natural Products Dept, National Research Center, Dokki,,Egypt
2Egypt
3National Research Center
4Pharmaceutical Chemistry Dept
5Pharmaceutical Chemistry Dept., Faculty of Pharmacy, Helwan University, Egypt
6Pharmaceutical Sciences Dept, Irma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center,,USA
7Texas A&M Health Science Center
8 Cairo University
9Faculty of Pharmacy
10Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Egypt
11Mapco Pharmaceutical industries Balteim
12Research Unit, Mapco Pharmaceutical Industries Balteim, Egypt

Tóm tắt

Furochromone and benzofuran derivatives were synthesized, docked and evaluated for their anti-VEGFR-2 activity, cytotoxicity, and in vivo antiprostate cancer activity.

Từ khóa


Tài liệu tham khảo

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