Design of a “Microbicide” for Prevention of Sexually Transmitted Diseases Using “Inactive” Pharmaceutical Excipients

Gerbase, 1998, Global prevalence and incidence estimates of selected curable STDs, Sex Transm Inf, 74, S12

Trees, 1995, Chancroid and Haemophilus ducreyi: an update, Clin Microb Rev, 8, 357, 10.1128/CMR.8.3.357

Rao, 1998, Systematic analysis of STD control: an operational model, Sex Transm Inf, 74, S17

Dallabetta, 1998, Problems, solutions, and challenges in syndromic management of sexually transmitted diseases, Sex Transm Inf, 74, S1

Burstein, 1998, Incident Chlamydia trachomatis infections among inner-city adolescent females, JAMA, 280, 521, 10.1001/jama.280.6.521

Fleming, 1997, Herpes simplex virus type 2 in the United States, 1976 to 1994, N Engl J Med, 337, 1105, 10.1056/NEJM199710163371601

Arvin, 1997, Herpes simplex virus type 2-a persistent problem, N Engl J Med, 337, 1158, 10.1056/NEJM199710163371609

Nahmias, 1990, Sero-epidemiological and -sociological patterns of herpes simplex virus infection in the world, Scand J Infect Dis, 69, 19

Engel, 1998, Long-term suppression of genital herpes, JAMA, 280, 928, 10.1001/jama.280.10.928

Krieger, 1995, Seminal shedding of human immunodeficiency virus type 1 and human cytomegalovirus:evidence for different immunologic controls, J Infect Dis, 171, 1018, 10.1093/infdis/171.4.1018

van der Meer, 1996, Summary of the international consensus symposium on advances in the diagnosis, treatment and prophylaxis of cytomegalovirus infection, Antiviral Res, 32, 119, 10.1016/S0166-3542(96)01006-6

Leach, 1994, Human herpesvirus 6 infection of the female genital tract, J Infect Dis, 169, 1281, 10.1093/infdis/169.6.1281

Howard, 1997, Detection of human herpesvirus 8 DNA in semen from HIV-infected individuals but not healthy semen donors, AIDS, 11, F15, 10.1097/00002030-199702000-00001

UNAIDS and WHO. Report on the global HIV/AIDS epidemic. Geneva: Joint United Nations Programme on HIV/AIDS. 1 June 1998

Alexander, 1996, Barriers to sexually transmitted diseases, Scientific American Science & Medicine, 3, 32

Hicks, 1985, Inactivation of HTLV-III/LAV-infected cultures of normal human lymphocytes by nonoxynol-9 in vitro, Lancet, 2, 1422, 10.1016/S0140-6736(85)92584-X

Jennings, 1993, The inhibitory effect of spermicidal agents on replication of HSV-2 and HIV-1 in vitro, J Antimicrob Chemother, 32, 71, 10.1093/jac/32.1.71

Sugarman, 1988, Effects of antimicrobial agents on growth and chemotaxis of Trichomonas vaginalis, Antimicrob Agents Chemother, 32, 1323, 10.1128/AAC.32.9.1323

Lyons, 1995, Reducing the risk of Chlamydia trachomatis genital tract infection by evaluating the prophylactic potential of vaginally applied chemicals, Clin Infect Dis, 21, S174, 10.1093/clinids/21.Supplement_2.S174

Stafford, 1998, Safety study of nonoxynol-9 as a vaginal microbicide: evidence of adverse effects, J Acquir Immun Defic Synd Hum Retrovir, 17, 327, 10.1097/00042560-199804010-00006

Rosenstein, 1998, Effect on normal vaginal flora of three intravaginal microbicidal agents potentially active against human immunodeficiency virus type 1, J Infect Dis, 177, 1386, 10.1086/517820

Kilmarx, 1998, Mucosal disruption due to use of a widely-distributed commercial vaginal product: potential to facilitate HIV transmission, AIDS, 12, 767, 10.1097/00002030-199807000-00013

Roddy, 1998, A controlled trial of nonoxynol 9 film to reduce male-to-female transmission of sexually transmitted diseases, N Engl J Med, 339, 504, 10.1056/NEJM199808203390803

Neurath, 1996, Bovine β-lactoglobulin modified by 3-hydroxypthalic anhydride blocks the CD4 cell receptor for HIV, Nature Med, 2, 230, 10.1038/nm0296-230

Neurath, 1997, 3-Hydroxyphthaloyl β-lactoglobulin. I. Optimization of production and comparison with other compounds considered for chemoprophylaxis of mucosally transmitted human immunodeficiency virus type 1, Antiviral Chem Chemother, 8, 131, 10.1177/095632029700800207

Neurath, 1997, 3-Hydroxyphthaloyl β-lactoglobulin. ll. Anti-human immunodeficiency virus type 1 activity in in vitro environments relevant to prevention of sexual transmission of the virus, Antiviral Chem Chemother, 8, 141, 10.1177/095632029700800208

Neurath, 1998, 3-Hydroxyphthaloyl β-lactoglobulin. lll. Antiviral activity against herpesviruses, Antiviral Chem Chemother, 9, 177, 10.1177/095632029800900209

Kokuba, 1998, 3Hydroxyphthaloyl β-lactoglobulin. IV. Antiviral activity in the mouse model of genital herpesvirus infection, Antiviral Chem Chemother, 9, 353, 10.1177/095632029800900407

Neurath, AR, Strick, N, Lin, K, Microbicide B195. Proceedings of the 12th World AIDS Conference, Geneva, Switzerland, June 28-July 3, 1998, Monduzzi Editore, Bologna, pp239, 242

Jiang, 1993, HIV-1 inhibition, Nature, 365, 113, 10.1038/365113a0

Jiang, 1991, Enhancement of human immunodeficiency virus type 1 infection by antibodies to peptide from the envelope glycoprotein gp120/gp41, J Exp Med, 174, 1557, 10.1084/jem.174.6.1557

Weislow, 1989, New soluble-formazan assay for HIV-1 cytopathic effects: application to high-flux screening of synthetic and natural products for AIDS-antiviral activity, J Natl Cancer Inst, 81, 577, 10.1093/jnci/81.8.577

Stabell, 1992, Isolation of a cell line for rapid and sensitive histochemical assay for the detection of herpes simplex virus, J Virol Methods, 38, 195, 10.1016/0166-0934(92)90110-Y

Weir, 1990, An insertion vector for the analysis of gene expression during herpes simplex virus infection, Gene, 89, 271, 10.1016/0378-1119(90)90016-K

Spaete, 1985, Regulation of cytomegalovirus gene expression: α and β promoters are trans activated by viral functions in permissive human fibroblasts, J Virol, 56, 135, 10.1128/JVI.56.1.135-143.1985

Wade, A, Weller, PJ, Handbook of Pharmaceutical Excipients. 2nd Edn, American Pharmaceutical Association, Washington, 1994

Ohkawa, 1992, The incidence of Trichomonas vaginalis in chromic prostatitis patients determined by culture using a newly modified liquid medium, J Infect Dis, 166, 1205, 10.1093/infdis/166.5.1205

Effcacy Data Requirements: Virucides DISITSS-7, 12 Nov 1981, Modifying AOAC Methods 4.007–4.014. Offce of Pesticide Research, Environmental Protection Agency, Washington DC

Mann, 1992, AIDS in the World, Cambridge: Harvard University Press

Perine, 1994, Sexually transmitted diseases in the tropics, Med J Aust 160, 160, 358, 10.5694/j.1326-5377.1994.tb138239.x

St. Louis, 1998, HIV prevention through early detection and treatment of other sexually transmitted diseases—United States. Recommendations of the Advisory Committee for HIV and STD Prevention, Mor Mort Wkly Rep, 47, 1

Over, 1996, Human immunodeficiency virus infection and other sexually transmitted diseases in developing countries: public health importance and priorities for resource allocation, J Infect Dis, 174, 162, 10.1093/infdis/174.Supplement_2.S162

Javan, 1997, Anti-HIV type 1 activity of sulfated derivatives of dextrin against primary viral isolates of HIV type 1 in lymphocytes and monocyte-derived macrophages, AIDS Res Human Retroviruses, 13, 875, 10.1089/aid.1997.13.875

Stafford, 1997, A placebo-controlled, double blind prospective study in healthy female volunteers of dextrin sulphate gel: a novel potential intravaginal virucide, J Acquir Immune Defic Syndr Hum Retrovirol, 14, 213, 10.1097/00042560-199703010-00003

Zacharopoulos, 1997, Vaginal formulations of carrageenan protect mice from herpes simplex virus infection, Clin Diagn Lab Immunol, 4, 465, 10.1128/CDLI.4.4.465-468.1997

Carlucci, 1997, Antiherpetic and anticoagulant properties of carrageenans from the red seaweed Gigartina skottsbergii and their cyclized derivatives: correlation between structure and biological activity, Int J Biol Macromol, 20, 97, 10.1016/S0141-8130(96)01145-2

Rusconi, 1996, Naphthalene sulfonate polymers with CD4-blocking and anti-human immunodeficiency virus type 1 activities, Antimicrob Agents Chemother, 40, 234, 10.1128/AAC.40.1.234

McClure, 1992, Investigations into the mechanism by which sulfated polysaccharides inhibit HIV infection in vitro, AIDS Res Hum Retroviruses, 8, 19, 10.1089/aid.1992.8.19

Tamamura, 1995, Synthesis of protegrin-related peptides and their antibacterial and anti-human immunodeficiency virus activity, Chem Pharm Bull (Tokyo), 43, 853, 10.1248/cpb.43.853

Lehrer, 1996, Endogenous vertebrate antibiotics. Defensins, protegrins, and other cysteine-rich antimicrobial peptides, Ann NY Acad Sci, 797, 228, 10.1111/j.1749-6632.1996.tb52963.x

Qu, 1997, Protegrin structure and activity against Neisseria gonorrhoeae, Infect Immun, 65, 636, 10.1128/IAI.65.2.636-639.1997

Hawes, 1995, Hydrogen peroxide-producing lactobacilli and acquisition of vaginal infections, J Infect Dis, 172, 756

Franco, 1995, Transmission of cervical human papillomavirus infection by sexual activity: differences between low and high oncogenic risk types, J Infect Dis, 172, 756, 10.1093/infdis/172.3.756

Bosch, 1994, Importance of human papillomavirus endemicity in the incidence of cervical cancer: an extension of the hypothesis on sexual behavior, Cancer Epidemiol, Biomarkers & Prev, 3, 375