Design for optimization of nanoparticles integrating biomaterials for orally dosed insulin

Yih, 2006, Engineered nanoparticles as precise drug delivery systems, J. Cell. Biochem., 97, 1184, 10.1002/jcb.20796

Reis, 2007, Nanoparticulate delivery system for insulin: design, characterization and in vitro/in vivo bioactivity, Eur. J. Pharm. Sci., 30, 392, 10.1016/j.ejps.2006.12.007

Reis, 2008, Nanoparticulate biopolymers deliver insulin orally eliciting pharmacological response, J. Pharm. Sci., 97, 5290, 10.1002/jps.21347

Arbit, 2004, The physiological rationale for oral insulin administration, Diabetes Technol. Ther., 6, 510, 10.1089/1520915041705929

Woitiski, 2008, Strategies toward the improved oral delivery of insulin nanoparticles via gastrointestinal uptake and translocation, Biodrugs, 22, 223, 10.2165/00063030-200822040-00002

Sarmento, 2007, Alginate/chitosan nanoparticles are effective for oral insulin delivery, Pharm. Res., 24, 2198, 10.1007/s11095-007-9367-4

Sarmento, 2007, Oral bioavailability of insulin contained in polysaccharide nanoparticles, Biomacromolecules, 8, 3054, 10.1021/bm0703923

Sarmento, 2007, Insulin-loaded nanoparticles are prepared by alginate ionotropic pre-gelation followed by chitosan polyelectrolyte complexation, J. Nanosci. Nanotechnol., 7, 1, 10.1166/jnn.2007.609

Rajaonarivony, 1993, Development of a new drug carrier made from alginate, J. Pharm. Sci., 82, 912, 10.1002/jps.2600820909

Illum, 1998, Chitosan and its use as a pharmaceutical excipient, Pharm. Res., 15, 1326, 10.1023/A:1011929016601

Artursson, 1994, Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (caco-2), Pharm. Res., 11, 1358, 10.1023/A:1018967116988

Yunyu, 2005, Immobilization of cells in polysaccharide gels, 867

Kamiya, 2003, Controlling the rate of protein release from polyelectrolyte complexes, Biotechnol. Bioeng., 82, 590, 10.1002/bit.10606

Sarmento, 2006, Development and characterization of new insulin containing polysaccharide nanoparticles, Colloids Surf. B Biointerfaces, 53, 193, 10.1016/j.colsurfb.2006.09.012

Lopez-Leon, 2005, Physicochemical characterization of chitosan nanoparticles: electrokinetic and stability behavior, J. Colloid Interface Sci., 283, 344, 10.1016/j.jcis.2004.08.186

C.B. Woitiski, R.J. Neufeld, A.J. Ribeiro, F.B. Veiga, Colloidal carrier integrating biomaterials for oral insulin delivery: influence of component formulation on physicochemical and biological parameters, Acta Biomater, in press, doi: 10.1016/j.actbio.2009.03.007.

Hirsjarvi, 2000, Surface pressure measurements in particle interaction and stability studies of poly(lactic acid) nanoparticles, Int. J. Pharm., 348, 153, 10.1016/j.ijpharm.2007.07.008

Nakamura, 2008, Key functions in polymer carriers for intestinal absorption of insulin, Int. J. Pharm., 354, 135, 10.1016/j.ijpharm.2007.10.050

Reis, 2008, Polyelectrolyte biomaterial interactions provide nanoparticulate carrier for oral insulin delivery, Drug Deliv., 15, 127, 10.1080/10717540801905165

Hurteaux, 2005, Coating alginate microspheres with a serum albumin–alginate membrane: application to the encapsulation of a peptide, Eur. J. Pharm. Sci., 24, 187, 10.1016/j.ejps.2004.10.010

Ferreira, 2007, Box–Behnken design: an alternative for the optimization of analytical methods, Anal. Chim. Acta, 597, 179, 10.1016/j.aca.2007.07.011

Chopra, 2007, Optimization of polyherbal gels for vaginal drug delivery by Box–Behnken statistical design, Eur. J. Pharm. Biopharm., 67, 120, 10.1016/j.ejpb.2006.12.013

Chopra, 2007, Release modulating hydrophilic matrix system of losartan potassium: optimisation of formulation using statistical experimental design, Eur. J. Pharm. Biopharm., 66, 73, 10.1016/j.ejpb.2006.09.001

Box, 1960, Some new three level designs for the study of quantitative variables, Technometrics, 2, 455, 10.2307/1266454

Desai, 1996, Gastrointestinal uptake of biodegradable microparticles: effect of particle size, Pharm. Res., 13, 1838, 10.1023/A:1016085108889

Benita, 1993, Submicron emulsions as colloidal drug carriers for intravenous administration: comprehensive physicochemical characterization, J. Pharm. Sci., 82, 1069, 10.1002/jps.2600821102

Vauthier, 2008, How to concentrate nanoparticles and avoid aggregation?, Eur. J. Pharm. Biopharm., 69, 466, 10.1016/j.ejpb.2008.01.025

Motwani, 2008, Chitosan–sodium alginate nanoparticles as submicroscopic reservoirs for ocular delivery: formulation, optimization and in vitro characterization, Eur. J. Pharm. Biopharm., 68, 513

Myers, 2002

Kim, 2007, Development and optimization of a novel oral controlled delivery system for tamsulosin hydrochloride using response surface methodology, Int. J. Pharm., 341, 97, 10.1016/j.ijpharm.2007.03.051

Thu, 1996, Alginate polycation microcapsules: I. Interaction between alginate and polycation, Biomaterials, 17, 1031, 10.1016/0142-9612(96)84680-1

Gan, 2007, Chitosan nanoparticle as protein delivery carrier – systematic examination of fabrication conditions for efficient loading and release, Colloids Surf. B Biointerfaces, 59, 24, 10.1016/j.colsurfb.2007.04.009

Yao, 1994, Swelling kinetics and release characteristics of crosslinked chitosan–polyether network (semi-IPN) hydrogels, J. Polym. Sci. A Polym. Chem., 32, 1213, 10.1002/pola.1994.080320702

Ibrahim, 2005, Stability of insulin during the erosion of poly(lactic acid) and poly(lactic-co-glycolic acid) microspheres, J. Control. Release, 106, 241, 10.1016/j.jconrel.2005.02.025

Morishita, 2004, Mucosal insulin delivery system based on complexation polymer hydrogels: effect of particle size on insulin enteral absorption, J. Control Release, 97, 115, 10.1016/j.jconrel.2004.03.008

Florence, 2004, Issues in oral nanoparticle drug carrier uptake and targeting, J. Drug Target, 12, 65, 10.1080/10611860410001693706