Design, characterization and in vitro evaluation of thin films enriched by tannic acid complexed by Fe(III) ions

Progress in Biomaterials - 2020
Beata Kaczmarek1, Olha Mazur1, Oliwia Miłek2, Marta Michalska‐Sionkowska3, Anamika Das4, Amit Jaiswal4, Jithin Vishnu4, Khyati R. Tiwari4, Alina Sionkowska3, Anna M. Osyczka2, Geetha Manivasagam4
1Department of Biomaterials and Cosmetics Chemistry, Faculty of Chemistry, Nicolaus Copernicus University in Toruń, Gagarin 7, 87-100, Torun, Poland
2Department of Cell Biology and Imaging, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University in Kraków, Gronostajowa 7, Krakow, Poland
3Department of Environmental Microbiology and Biotechnology, Faculty of Biology and Veterinary Science, Nicolaus Copernicus University in Toruń, Lwowska 1, Torun, Poland
4Centre for Biomaterials Cellular and Molecular Theranostics, Vellore Institute of Technology, Vellore, Tamil Nadu, India

Tóm tắt

AbstractMaterials based on carbohydrate polymers may be used for biomedical application. However, materials based on natural polymers have weak physicochemical properties. Thereby, there is a challenge to improve their properties without initiation of toxicity. The alternative method compared to toxic chemical agents’ addition is the use of metal complexation method. In this study, chitosan/tannic acid mixtures modified by Fe(III) complexation are proposed and tested for potential applications as wound dressings. Thereby, surface properties, blood compatibility as well as platelet adhesion was tested. In addition, the periodontal ligament stromal cells compatibility studies were carried out. The results showed that the iron(III) addition to chitosan/tannic acid mixture improves properties due to a decrease in the surface free energy and exhibited a reduction in the hemolysis rate (below 5%). Moreover, cells cultured on the surface of films with Fe(III) showed higher metabolic activity. The current findings allow for the medical application of the proposed materials as wound dressings.

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Progress in Biomaterials

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