Design and potential application of PEGylated gold nanoparticles with size-dependent permeation through brain microvasculature

Maeda, 2001, The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting, Adv Enzyme Regul, 41, 189, 10.1016/S0065-2571(00)00013-3 Greish, 2007, Enhanced permeability and retention of macromolecular drugs in solid tumors: a royal gate for targeted anticancer nanomedicines, J Drug Target, 15, 457, 10.1080/10611860701539584 Schneider, 2004, Glioblastoma cells release factors that disrupt blood-brain barrier features, Acta Neuropathol, 107, 272, 10.1007/s00401-003-0810-2 Criscuolo, 1993, The genesis of peritumoral vasogenic brain edema and tumor cysts: a hypothetical role for tumor-derived vascular permeability factor, Yale J Biol Med, 66, 277 Strugar, 1994, Vascular permeability factor in brain metastases: correlation with vasogenic brain edema and tumor angiogenesis, J Neurosurg, 81, 560, 10.3171/jns.1994.81.4.0560 Gerstner, 2009, VEGF inhibitors in the treatment of cerebral edema in patients with brain cancer, Nat Rev Clin Oncol, 6, 229, 10.1038/nrclinonc.2009.14 Stummer, 2007, Mechanisms of tumor-related brain edema, Neurosurg Focus, 22, E8, 10.3171/foc.2007.22.5.9 Connor, 2005, Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity, Small, 1, 325, 10.1002/smll.200400093 Male, 2008, Assessment of cytotoxicity of quantum dots and gold nanoparticles using cell-based impedance spectroscopy, Anal Chem, 80, 5487, 10.1021/ac8004555 Paciotti, 2004, Colloidal gold: a novel nanoparticle vector for tumor directed drug delivery, Drug Deliv, 11, 169, 10.1080/10717540490433895 Hainfeld, 2004, The use of gold nanoparticles to enhance radiotherapy in mice, Phys Med Biol, 49, N309, 10.1088/0031-9155/49/18/N03 Mukherjee, 2005, Antiangiogenic properties of gold nanoparticles, Clin Cancer Res, 11, 3530, 10.1158/1078-0432.CCR-04-2482 Brown, 2010, Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin, J Am Chem Soc, 132, 4678, 10.1021/ja908117a Cheng, 2008, Highly efficient drug delivery with gold nanoparticle vectors for in vivo photodynamic therapy of cancer, J Am Chem Soc, 130, 10643, 10.1021/ja801631c Hirsch, 2003, Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance, Proc Natl Acad Sci U S A, 100, 13549, 10.1073/pnas.2232479100 Visaria, 2006, Enhancement of tumor thermal therapy using gold nanoparticle-assisted tumor necrosis factor-alpha delivery, Mol Cancer Ther, 5, 1014, 10.1158/1535-7163.MCT-05-0381 Huang, 2008, Plasmonic photothermal therapy (PPTT) using gold nanoparticles, Lasers Med Sci, 23, 217, 10.1007/s10103-007-0470-x Bernardi, 2008, Immunonanoshells for targeted photothermal ablation in medulloblastoma and glioma: an in vitro evaluation using human cell lines, J Neurooncol, 86, 165, 10.1007/s11060-007-9467-3 Schwartz, 2009, Feasibility study of particle-assisted laser ablation of brain tumors in orthotopic canine model, Cancer Res, 69, 1659, 10.1158/0008-5472.CAN-08-2535 Libutti, 2010, Phase I and pharmacokinetic studies of CYT-6091, a novel PEGylated colloidal gold-rhTNF nanomedicine, Clin Cancer Res., 16, 6139, 10.1158/1078-0432.CCR-10-0978 Veiseh, 2005, Optical and MRI multifunctional nanoprobe for targeting gliomas, Nano Lett, 5, 1003, 10.1021/nl0502569 Kohler, 2004, A bifunctional poly(ethylene glycol) silane immobilized on metallic oxide-based nanoparticles for conjugation with cell targeting agents, J Am Chem Soc, 126, 7206, 10.1021/ja049195r Cai, 2006, Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects, Nano Lett, 6, 669, 10.1021/nl052405t Susumu, 2007, Enhancing the stability and biological functionalities of quantum dots via compact multifunctional ligands, J Am Chem Soc, 129, 13987, 10.1021/ja0749744 Liu, 2007, Dai H. siRNA delivery into human T cells and primary cells with carbon-nanotube transporters, Angew Chem Int Edn Engl, 46, 2023, 10.1002/anie.200604295 Dixit, 2006, Synthesis and grafting of thioctic acid-PEG-folate conjugates onto Au nanoparticles for selective targeting of folate receptor-positive tumor cells, Bioconjug Chem, 17, 603, 10.1021/bc050335b Perrault, 2009, Mediating tumor targeting efficiency of nanoparticles through design, Nano Lett, 9, 1909, 10.1021/nl900031y Sonavane, 2008, Biodistribution of colloidal gold nanoparticles after intravenous administration: effect of particle size, Colloids Surf B Biointerfaces, 66, 274, 10.1016/j.colsurfb.2008.07.004 De Jong, 2008, Particle size-dependent organ distribution of gold nanoparticles after intravenous administration, Biomaterials, 29, 1912, 10.1016/j.biomaterials.2007.12.037 Frens, 1973, Controlled nucleation for the regulation of the particle size in monodisperse gold suspensions, Nature, 241, 20 Garberg, 2005, In vitro models for the blood-brain barrier, Toxicol in Vitro, 19, 299, 10.1016/j.tiv.2004.06.011 Culot, 2008, An in vitro blood-brain barrier model for high throughput (HTS) toxicological screening, Toxicol in Vitro, 22, 799, 10.1016/j.tiv.2007.12.016 Stanness, 1997, Morphological and functional characterization of an in vitro blood-brain barrier model, Brain Res, 771, 329, 10.1016/S0006-8993(97)00829-9 Nakagawa, 2009, A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes, Neurochem Int, 54, 253, 10.1016/j.neuint.2008.12.002 Romberg, 2008, Sheddable coatings for long-circulating nanoparticles, Pharm Res, 25, 55, 10.1007/s11095-007-9348-7 Moghimi, 2001, Long-circulating and target-specific nanoparticles: theory to practice, Pharmacol Rev, 53, 283 Owens, 2006, Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles, Int J Pharm, 307, 93, 10.1016/j.ijpharm.2005.10.010 Alkilany, 2009, Cellular uptake and cytotoxicity of gold nanorods: molecular origin of cytotoxicity and surface effects, Small, 5, 701, 10.1002/smll.200801546 Chithrani, 2007, Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes, Nano Lett, 7, 1542, 10.1021/nl070363y Chithrani, 2006, Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells, Nano Lett, 6, 662, 10.1021/nl052396o Semmler-Behnke, 2008, Biodistribution of 1.4- and 18-nm gold particles in rats, Small, 4, 2108, 10.1002/smll.200800922 Terentyuk, 2009, Circulation and distribution of gold nanoparticles and induced alterations of tissue morphology at intravenous particle delivery, J Biophotonics, 2, 292, 10.1002/jbio.200910005