Depressive symptoms and metabolic syndrome components among older Chinese adults

Diabetology & Metabolic Syndrome - Tập 12 - Trang 1-7 - 2020
Jing-Hong Liu1, Yu-Xi Qian1, Qing-Hua Ma2, Hong-Peng Sun1, Yong Xu1, Chen-Wei Pan
1School of Public Health, Medical College of Soochow University, Suzhou, China
2The 3rd People’s Hospital of Xiangcheng District, Suzhou, China

Tóm tắt

Few studies examined associations between depressive symptoms and metabolic syndrome (MetS) among older Chinese adults. Considering that the prevalence of depressive symptoms is high in older Chinese adults, we aimed to examine associations of depressive symptoms with MetS and its components in older Chinese adults. Data from a community-based cross-sectional study of 4579 Chinese adults aged 60 years or older were analyzed. Depressive symptoms were assessed using the nine-item Patient Health Questionnaire. The presence of MetS was defined based on the Adult Treatment Panel III criteria, which include obesity, reduced blood high-density lipoprotein, high blood pressure (BP), elevated fasting plasma glucose and hypertriglyceridemia. A participant was considered as having MetS if he or she met at least three of the above-mentioned criteria. In all participants, depressive symptoms were related to elevated fasting plasma glucose (≥ 7.0 mmol/L) (adjusted odds ratio [OR] = 1.50, 95% confidence interval [CI] [1.00–2.20]) and diabetes (adjusted OR = 1.50, 95% CI [1.01–2.20]). The associations of depressive symptoms with MetS and its components were not significant among women. However, there was a negative association between depressive symptoms and elevated systolic BP (≥ 130 mm Hg) (OR = 0.59, 95% CI [0.4–0.9]), and similar findings were observed after adjusting for lifestyle-related variables in men. In older Chinese adults, depressive symptoms were negatively associated with elevated systolic BP in men while these findings were not found in women.

Tài liệu tham khảo

WHO. Depression and other common mental disorders: Global Health estimates. Geneva: World Health Organization; 2017. Luppa M, Sikorski C, Luck T, Ehreke L, Konnopka A, Wiese B, Weyerer S, Konig HH, Riedel-Heller SG. Age- and gender-specific prevalence of depression in latest-life–systematic review and meta-analysis. J Affect Disord. 2012;136(3):212–21. Forlani C, Morri M, Ferrari B, Dalmonte E, Menchetti M, De Ronchi D, Atti AR. Prevalence and gender differences in late-life depression: a population-based study. Am J Geriatr Psychiatry. 2014;22(4):370–80. Sjoberg L, Karlsson B, Atti AR, Skoog I, Fratiglioni L, Wang HX. Prevalence of depression: comparisons of different depression definitions in population-based samples of older adults. J Affect Disord. 2017;221:123–31. Goncalves-Pereira M, Prina AM, Cardoso AM, da Silva JA, Prince M, Xavier M. The prevalence of late-life depression in a Portuguese community sample: a 10/66 Dementia Research Group study. J Affect Disord. 2018;246:674–81. Stunkard AJ, Faith MS, Allison KC. Depression and obesity. Biol Psychiat. 2003;54(3):330–7. Viscogliosi G, Andreozzi P, Chiriac IM, Cipriani E, Servello A, Marigliano B, Ettorre E, Marigliano V. Depressive symptoms in older people with metabolic syndrome: is there a relationship with inflammation? Int J Geriatr Psychiatry. 2013;28(3):242–7. DeBoer MD, Gurka MJ, Woo JG, Morrison JA. Severity of metabolic syndrome as a predictor of cardiovascular disease between childhood and adulthood: the princeton lipid Research Cohort Study. J Am Coll Cardiol. 2015;66(6):755–7. Rethorst CD, Bernstein I, Trivedi MH. Inflammation, obesity, and metabolic syndrome in depression: analysis of the 2009-2010 National Health and Nutrition Examination Survey (NHANES). J Clin Psychiatry. 2014;75(12):e1428–32. Block A, Schipf S, Van der Auwera S, Hannemann A, Nauck M, John U, Volzke H, Freyberger HJ, Dorr M, Felix S, et al. Sex- and age-specific associations between major depressive disorder and metabolic syndrome in two general population samples in Germany. Nord J Psychiatry. 2016;70(8):611–20. Gurka MJ, Vishnu A, Okereke OI, Musani S, Sims M, DeBoer MD. Depressive symptoms are associated with worsened severity of the metabolic syndrome in African American women independent of lifestyle factors: a consideration of mechanistic links from the Jackson heart study. Psychoneuro Endocrinol. 2016;68:82–90. Sekita A, Arima H, Ninomiya T, Ohara T, Doi Y, Hirakawa Y, Fukuhara M, Hata J, Yonemoto K, Ga Y, et al. Elevated depressive symptoms in metabolic syndrome in a general population of Japanese men: a cross-sectional study. BMC Public Health. 2013;13:862. Hildrum B, Mykletun A, Midthjell K, Ismail K, Dahl AA. No association of depression and anxiety with the metabolic syndrome: the Norwegian HUNT study. Acta Psychiatr Scand. 2009;120(1):14–22. Li D, Zhang DJ, Shao JJ, Qi XD, Tian L. A meta-analysis of the prevalence of depressive symptoms in Chinese older adults. Arch Gerontol Geriatr. 2014;58(1):1–9. Pan CW, Wang X, Ma Q, Sun HP, Xu Y, Wang P. Cognitive dysfunction and health-related quality of life among older Chinese. Sci Rep. 2015;5:17301. Pan CW, Cong XL, Zhou HJ, Wang XZ, Sun HP, Xu Y, Wang P. Evaluating health-related quality of life impact of chronic conditions among older adults from a rural town in Suzhou, China. Arch Gerontol Geriatr. 2018;76:6–11. Kroenke K, Spitzer RL, Williams JB, Lowe B. The patient health questionnaire somatic, anxiety, and depressive symptom scales: a systematic review. Gen Hosp Psychiatry. 2010;32(4):345–59. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001;16(9):606–13. Badr H, Federman AD, Wolf M, Revenson TA, Wisnivesky JP. Depression in individuals with chronic obstructive pulmonary disease and their informal caregivers. Aging Mental Health. 2017;21(9):975–82. Expert Panel on Detection E. Executive summary of the third report of the national cholesterol education program (ncep) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). JAMA. 2001;285(19):2486–97. Sabanayagam C, Wang JJ, Mitchell P, Tan AG, Tai ES, Aung T, Saw SM, Wong TY. Metabolic syndrome components and age-related cataract: the Singapore Malay eye study. Invest Ophthalmol Vis Sci. 2011;52(5):2397–404. Wang H, Sun HP, Wang P, Xu Y, Pan CW. Cataract and depressive symptoms among older Chinese adults. Optom Vis Sci. 2016;93(12):1479–84. Yu M, Zhang X, Lu F, Fang L. Depression and risk for diabetes: a meta-analysis. Can J Diab. 2015;39(4):266–72. Graham E, Au B, Schmitz N. Depressive symptoms, prediabetes, and incident diabetes in older english adults. Int J Geriatr Psychiatry. 2017;32(12):1450–8. Peng YF, Zhong SM, Qin YH. The relationship between major depressive disorder and glucose parameters: a cross-sectional study in a Chinese population. Adv Clin Exp Med. 2017;26(4):665–9. Vogelzangs N, Kritchevsky SB, Beekman AT, Newman AB, Satterfield S, Simonsick EM, Yaffe K, Harris TB, Penninx BW. Depressive symptoms and change in abdominal obesity in older persons. Arch Gen Psychiatry. 2008;65(12):1386–93. Diniz BS, Teixeira AL, Campos AC, Miranda AS, Rocha NP, Talib LL, Gattaz WF, Forlenza OV. Reduced serum levels of adiponectin in elderly patients with major depression. J Psychiatr Res. 2012;46(8):1081–5. Joseph JJ, Golden SH. Cortisol dysregulation: the bidirectional link between stress, depression, and type 2 diabetes mellitus. Ann N Y Acad Sci. 2017;1391(1):20–34. Scuteri A, Spalletta G, Cangelosi M, Gianni W, Assisi A, Brancati AM, Modestino A, Caltagirone C, Volpe M. Decreased nocturnal systolic blood pressure fall in older subjects with depression. Aging Clin Exp Res. 2009;21(4–5):292–7. Licht CM, de Geus EJ, Seldenrijk A, van van Hout HP, Zitman FG, Dyck R, Penninx BW. Depression is associated with decreased blood pressure, but antidepressant use increases the risk for hypertension. Hypertension. 2009;53(4):631–8 (Dallas, Tex: 1979). Niu K, Hozawa A, Awata S, Guo H, Kuriyama S, Seki T, Ohmori-Matsuda K, Nakaya N, Ebihara S, Wang Y, et al. Home blood pressure is associated with depressive symptoms in an elderly population aged 70 years and over: a population-based, cross-sectional analysis. Hypertens Res. 2008;31(3):409–16. Hildrum B, Romild U, Holmen J. Anxiety and depression lowers blood pressure: 22-year follow-up of the population based HUNT study, Norway. BMC Public health. 2011;11:601. Shinn EH, Poston WS, Kimball KT, St Jeor ST, Foreyt JP. Blood pressure and symptoms of depression and anxiety: a prospective study. Am J Hypertens. 2001;14(7 Pt 1):660–4. Van der Kooy K, van Hout H, Marwijk H, Marten H, Stehouwer C, Beekman A. Depression and the risk for cardiovascular diseases: systematic review and meta analysis. Int J Geriatr Psychiatry. 2007;22(7):613–26. Steffens DC, Krishnan KR, Crump C, Burke GL. Cerebrovascular disease and evolution of depressive symptoms in the cardiovascular health study. Stroke. 2002;33(6):1636–44. Marijnissen RM, Smits JE, Schoevers RA, van den Brink RH, Holewijn S, Franke B, de Graaf J, Oude Voshaar RC. Association between metabolic syndrome and depressive symptom profiles–sex-specific? J Affect Disord. 2013;151(3):1138–42. Michalkiewicz M, Knestaut KM, Bytchkova EY, Michalkiewicz T. Hypotension and reduced catecholamines in neuropeptide Y transgenic rats. Hypertension. 2003;41(5):1056–62 (Dallas, Tex: 1979). Karl T, Herzog H. Behavioral profiling of NPY in aggression and neuropsychiatric diseases. Peptides. 2007;28(2):326–33. Tikhonoff V, Hardy R, Deanfield J, Friberg P, Kuh D, Muniz G, Pariante CM, Hotopf M, Richards M. Symptoms of anxiety and depression across adulthood and blood pressure in late middle age: the 1946 British birth cohort. J Hypertens. 2014;32(8):1590–8 (discussion 1599). Sutin AR, Beason-Held LL, Dotson VM, Resnick SM, Costa PT Jr. The neural correlates of Neuroticism differ by sex prospectively mediate depressive symptoms among older women. J Affect Disord. 2010;127(1–3):241–7. Barnes JN. Sex-specific factors regulating pressure and flow. Exp Physiol. 2017;102(11):1385–92. Kloner RA, Carson C 3rd, Dobs A, Kopecky S, Mohler ER 3rd. Testosterone and Cardiovascular Disease. J Am Coll Cardiol. 2016;67(5):545–57. Spitzer RL, Kroenke K, Williams JB. Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. JAMA. 1999;282(18):1737–44.