Depression and Sleep Disorders: Clinical Relevance, Economic Burden and Pharmacological Treatment

Neuropsychobiology - Tập 42 Số 3 - Trang 107-119 - 2000
N. Brunello1,2, Roseanne Armitage3, Irwin Feinberg4, Edith Holsboer‐Trachsler5, Damien Léger6, Paul Linkowski7, Wallace B. Mendelson8, Giorgio Racagni1,9, B. Saletu10, Ann L. Sharpley11, Fred W. Turek12, Eve Van Cauter13, Julien Mendlewicz7
1Centre of Neuropharmacology, Institute of Pharmacological Sciences, University of Milan, and
2Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia,
3Universtiy of Texas Southwestern Medical Center at Dallas, Tex.,
4VA/UCD Sleep Laboratory, Department of Psychiatry, University of California, Davis, Calif.,
5Psychiatrische Universitätsklinik, Basel, Switzerland
6Hôtel-Dieu Sleep Center, Paris, France
7Department of Psychiatry, Erasme Hospital, University of Brussels, Belgium
8Department of Neurology, Cleveland Clinic Foundation, Cleveland, Ohio,
9IRCCS Centro San Giovanni di Dio-Fatebenefratelli, Brescia, Italy
10Department of Psychiatry, School of Medicine, University of Vienna, Austria
11Psychopharmacology Research Unit, Oxford University Department of Psychiatry, Oxford, UK
12Department of Neurobiology and Physiology, Northwestern University, Evanston, Ill. and
13University of Chicago, Ill., USA

Tóm tắt

A wide range of studies have been published over the past two decades that involve the intersection of sleep EEG, insomnia, psychiatric illness (especially depressive disorders) and psychopharmacology. Much of value has been discovered, but there have also been false starts and contradictory results. There is in fact strong evidence that insomnia is associated with medical and psychiatric illness and that the sleepiness associated with insomnia is the cause of many accidents. Thus, the direct (visits to doctors, cost of sleeping medication, complications from use of these medications) and indirect (accidents, quality of life) costs of insomnia are enormous and constitute a major public health problem in the industrialized countries. Believing that it is now timely to assess the state of this important research area, a consensus conference was convened on June 26–28, 1998, in Porto Cervo (Italy) to attempt to clarify the important issues and findings on the clinical effect of the different classes of antidepressant drugs on sleep quality in depression. The participants’ consensus on some of the main topics is presented with the hope that this discussion and analysis will contribute to productive research in this important field.

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Tài liệu tham khảo

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Neuropsychobiology

Tập 42 Số 3

107-119

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