Dependence of Apatite Formation on Silica Gel on Its Structure: Effect of Heat Treatment

Journal of the American Ceramic Society - Tập 78 Số 7 - Trang 1769-1774 - 1995
Sung‐Baek Cho1, Kazuki Nakanishi1, Tadashi Kokubo1,2, Naohiro Soga1,2, Chikara Ohtsuki3, Takashi Nakamura4, Toshiaki Kitsugi5, Takao Yamamuro5
1Division of Material Chemistry, Kyoto University, Sakyo-ku, Kyoto 606-01, Japan
2*Member, American Ceramic Society.
3Department of Bioengineering Science, Okayama University, Okayama 700, Japan
4Research Center for Biomedical Engineering, Kyoto University, Sakyo-ku, Kyoto, 606, Japan
5Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto, 606, Japan

Tóm tắt

The prerequisite for glasses and glass‐ceramics to bond to living bone is the formation of biologically active bonelike apatite on their surfaces in the body. Our previous study showed that a silica gel prepared by hydrolysis and polycon‐ densation of tetraethoxysilane in aqueous solution containing poly(ethy1ene glycol) induces apatite nucleation on its surface in a simulated body fluid. In the present study, the effects of heat treatment of silica gel on its catalytic effects in apatite nucleation was investigated in a simulated body fluid. I t was found that apatite forms on the surfaces of silica gels heat‐treated below 8OO°C, but not on those heat‐treated above 900°C. The volume of nanometer‐range pores in the gel remarkably decreased by heat treatment above 900°C. The concentration of silanol groups in the silica gels gradually decreased with increasing heat treatment temperature. The rate of silica dissolution from the gel into the simulated body fluid decreased remarkably by heat treatment above 900°C. This suggested that a special type of silanol group which is formed by soaking the gel treated below 800°C into the simulated body fluid is respon sible for apatite nucleation.

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Tài liệu tham khảo

10.1002/jbm.820050611

Blencke B. A., 1975, Glass Ceramic–‐A New Bioactive Implant Material, Med.-Orthop. Tech., 95, 144

Kokubo T., 1982, Apatite‐ and Wallastonite‐Containing Glass‐Ceramics for Prosthetic Application, Bull. Inst. Chem. Res., Kyoto Univ., 60, 260

Holand W., 1983, Machinable Bioactive Glass Ceramic, Wiss. Z. Friedrich-Schiller-Univ. Jena, Math.-Naturwiss. Reihe., 32, 571

Anderson O. H., 1988, Model for Physical Properties and Bioactivity of Phosphate Opal Glasses, Glastech. Ber., 61, 300

10.1002/jbm.820230607

G.Berger F.Sauer G.Steinborn F. G.Wishsmann V.Thieme St.Kohler andH.Dressel “Clinical Application of Surface Reactive Apatite/Wollastonite Containing Glass‐Ceramics”; pp.120–26inProceedings of the 15th International Congress on Glass Vol. 3a. Edited by O. V. Mazurin. Nauka Leningrad U.S.S.R. 1989.

10.1002/jbm.820250307

Reck R., 1988, Annals of the New York Academy of Science, Vol. 523, Bioceramics: Material Characteristics versus in vivo Behavior, 100

Merwin G. E., 1990, Handbook of Bioactive Ceramics, Vol. 1, Bioactive Glasses and Glass‐Ceramics., 323

Yamamuro Y., 1990, Handbook of Bioactive Ceramics, Vol. 1, Bioactive Glasses and Glass‐Ceramics., 335

Gummel J., 1988, Replacement of the Lumbar Vertebral Bodies with Machinable Bioactive Glasses Ceramic, Z. Klin. Med., 43, 1791

Yamamuro T., 1990, Replacement of the Lumber Vertebrae of Sheep with Ceramic Prostheses, J. Bone J. Surg., Br. Vol., 72, 889, 10.1302/0301-620X.72B5.2211778

Yamamuro T., 1990, Handbook of Bioactive Ceramics, Vol. 1, Bioactive Glasses and Glass‐Ceramics., 343

Hench L. L., 1991, Bioceramics, 232

10.1002/jbm.820221004

Hench L. L., 1982, Biocompatibility of Orthopedic Implant, 129

10.1002/jbm.820200906

10.1002/jbm.820211008

10.1007/BF00268048

10.1002/jbm.820240306

10.1016/0022-3093(90)90199-V

Kokubo T., 1990, Handbook of Bioactive Ceramics, Vol. 1, Bioactive Glasses and Glass‐Ceramics., 41

Kokubo T., 1990, Bioceramics, 113

10.1002/jbm.820251105

Neo M., 1993, Bone Bonding Biomaterials., 111

10.1111/j.1151-2916.1991.tb07132.x

10.1016/0142-9612(91)90194-F

Hench L. L., 1988, Annals of the New York Academy of Sciences, Vol. 523, Bioceramics: Material Characteristics versus in Vivo Behavior, 54

10.1016/0022-3093(89)90495-X

10.2109/jcersj.99.1

10.1016/S0022-3093(05)80556-3

10.1111/j.1151-2916.1992.tb04470.x

10.1002/jab.770040303

10.1007/BF00120381

10.1016/0142-9612(93)90186-6

Gamble J., 1967, Chemical Anatomy, Physiology and Pathology of Extracellular Fluid, 1

10.1002/jbm.820240607

10.1007/BF00701083

Kokubo T., 1987, Ceramics in Clinical Applications., 175

10.1016/S0022-3093(86)80092-8

Her R. K., 1979, The Chemistry of Silica, 40

Neuman W., 1958, The Chemical Dynamics of Bone Mineral, 34

Li R., 1992, Chemical Processing of Advanced Materials., 627

West J. H., 1991, Bioceramics, 75

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Thông tin xuất bản

Journal of the American Ceramic Society

Tập 78 Số 7

1769-1774

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