Dentine as a bioactive extracellular matrix

Murray, 2002, Ageing human odontometric analysis, Oral Surg Oral Med Oral Pathol Oral Radiol, 93, 474, 10.1067/moe.2002.120974

Murray, 2002, Analysis of incisor cell populations in Wistar rats of different ages, Arch Oral Biol, 47, 709, 10.1016/S0003-9969(02)00055-9

Franquin, 1998, Immunocytochemical detection of apoptosis in human odontoblasts, Eur J Oral Sci, 106, 384, 10.1111/j.1600-0722.1998.tb02202.x

Couve, 2011, Autophagic activity and aging in human odontoblasts, J Dent Res, 90, 523, 10.1177/0022034510393347

Schour, 1939, Studies in tooth development: II. The rate of apposition of enamel and dentine in man and other mammals, J Dent Res, 18, 161, 10.1177/00220345390180020601

Ziskin, 1949, The effect of hypophysectomy upon the permanent dentition of rhesus monkeys, J Dent Res, 28, 48, 10.1177/00220345490280010601

Baume, 1980, Definitions and classifications of the pulpodentinal tissues

Simon, 2009, Molecular characterization of young and mature odontoblasts, Bone, 45, 693, 10.1016/j.bone.2009.06.018

Simon, 2010, The MAPK pathway is involved in odontoblast stimulation via p38 phosphorylation, J Endod, 36, 256, 10.1016/j.joen.2009.09.019

He, 2003, Nucleation of apatite crystals in vitro by self-assembled dentin matrix protein 1, Nat Mater, 2, 552, 10.1038/nmat945

Fisher, 2001, Flexible structures of SIBLING proteins, bone sialoprotein, and osteopontin, Biochem Biophys Res Commun, 280, 460, 10.1006/bbrc.2000.4146

Hunter, 1993, Nucleation of hydroxyapatite by bone sialoprotein, Proc Natl Acad Sci U S A, 90, 8562, 10.1073/pnas.90.18.8562

Goldberg, 1996, Determination of the hydroxyapatite-nucleating region of bone sialoprotein, Connect Tissue Res, 35, 385, 10.3109/03008209609029216

Butler, 2001, Dentin extracellular matrix (ECM) proteins: comparison to bone ECM and contribution to dynamics of dentinogenesis, Connect Tissue Res, 44, 171

Butler, 1995, The nature and functional significance of dentin extracellular matrix proteins, Int J Dev Biol, 39, 169

Ritchie, 1995, Molecular analysis of rat dentin sialoprotein, Connect Tissue Res, 33, 73, 10.3109/03008209509016985

Hart, 2007, Disorders of human dentin, Cells Tissues Organs, 186, 70, 10.1159/000102682

Sreenath, 2003, Dentin sialophosphoprotein knockout mouse teeth display widened predentin zone and develop defective dentin mineralization similar to human dentinogenesis imperfecta type III, J Biol Chem, 278, 24874, 10.1074/jbc.M303908200

Moses, 2006, Immunohistochemical study of small integrin-binding ligand, N-linked glycoproteins in reactionary dentin of rat molars at different ages, Eur J Oral Sci, 114, 216, 10.1111/j.1600-0722.2006.00353.x

Qin, 2004, Post-translational modifications of sibling proteins and their roles in osteogenesis and dentinogenesis, Crit Rev Oral Biol Med, 15, 126, 10.1177/154411130401500302

Boskey, 2008, Modulation of extracellular matrix protein phosphorylation alters mineralization in differentiating chick limb-bud mesenchymal cell micromass cultures, Bone, 42, 1061, 10.1016/j.bone.2008.01.016

Toyosawa, 2004, mRNA expression and protein localization of dentin matrix protein 1 during dental root formation, Bone, 34, 124, 10.1016/j.bone.2003.08.010

Ye, 2004, Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development, J Biol Chem, 279, 19141, 10.1074/jbc.M400490200

Feng, 2003, The dentin matrix protein 1 (Dmp1) is specifically expressed in mineralized, but not soft, tissues during development, J Dent Res, 82, 776, 10.1177/154405910308201003

Boskey, 1993, Osteopontin–hydroxyapatite interactions in vitro: inhibition of hydroxyapatite formation and growth in a gelatin-gel, Bone Miner, 22, 147, 10.1016/S0169-6009(08)80225-5

Boskey, 2002, Osteopontin deficiency increases mineral content and mineral crystallinity in mouse bone, Calcif Tissue Int, 71, 145, 10.1007/s00223-001-1121-z

MacDougall, 2002, MEPE/OF45 a new dentin/bone matrix protein and candidate gene for dentin diseases mapping to 4q21, Connect Tissue Res, 43, 373, 10.1080/713713461

Gowen, 2003, Targeted disruption of the osteoblast/osteocyte factor 45 gene (OF45) results in increased bone formation and bone mass, J Biol Chem, 17, 1998, 10.1074/jbc.M203250200

Chaussain-Miller, 2006, The role of matrix metalloproteinases (MMPs) in human caries, J Dent Res, 85, 22, 10.1177/154405910608500104

Papagerakis, 2002, Investigation of osteocalcin, osteonectin, and dentin sialophosphoprotein in developing human teeth, Bone, 30, 377, 10.1016/S8756-3282(01)00683-4

Goldberg, 2003, Proteoglycans in predentin: the last 15 micrometers before mineralization, Connect Tissue Res, 44, 184, 10.1080/03008200390152304

Embery, 2001, Proteoglycans in dentinogenesis, Crit Rev Oral Biol Med, 12, 331, 10.1177/10454411010120040401

Finkelman, 1990, Quantification of growth factors IGF-I, SGF/IGFII, and TGF-beta in human dentin, J Bone Miner Res, 5, 717, 10.1002/jbmr.5650050708

Cassidy, 1997, Comparative analysis of transforming growth factor-beta isoforms 1–3 in human and rabbit dentine matrices, Arch Oral Biol, 42, 219, 10.1016/S0003-9969(96)00115-X

Roberts-Clark, 2000, Angiogenic growth factors in human dentine matrix, Arch Oral Biol, 45, 1013, 10.1016/S0003-9969(00)00075-3

Zhao, 2000, Ultrastructural localisation of TGF-beta exposure in dentine by chemical treatment, Histochem J, 32, 489, 10.1023/A:1004100518245

Musson, 2010, Adrenomedullin is expressed during rodent dental tissue development and promotes cell growth and mineralisation, Biol Cell, 102, 145, 10.1042/BC20090122

Dobie, 2002, Effects of alginate hydrogels and TGF-beta 1 on human dental pulp repair in vitro, Connect Tissue Res, 43, 387, 10.1080/03008200290000574

Six, 2002, Osteogenic proteins (bone sialoprotein and bone morphogenetic protein-7) and dental pulp mineralization, J Mater Sci Mater Med, 13, 225, 10.1023/A:1013846516693

Graham, 2007, Cytokine release from human dentine, J Dent Res, 86

Cooper, 2010, Inflammation-regeneration interplay in the dentine–pulp complex, J Dent, 38, 687, 10.1016/j.jdent.2010.05.016

Levin, 1999, Expression of IL-8 by cells of the odontoblast layer in vitro, Eur J Oral Sci, 107, 131, 10.1046/j.0909-8836.1999.eos107209.x

Tani-Ishii, 1995, Immunolocalization of bone-resorptive cytokines in rat pulp and periapical lesions following surgical pulp exposure, Oral Microbiol Immunol, 10, 213, 10.1111/j.1399-302X.1995.tb00145.x

Silva, 2004, Dentin sialoprotein and phosphoprotein induce neutrophil recruitment: a mechanism dependent on IL-1beta, TNFbeta, and CXC chemokines, Calcif Tissue Int, 74, 532, 10.1007/s00223-003-0159-5

Silva, 2005, Macrophages and mast cells control the neutrophil migration induced by dentin proteins, J Dent Res, 84, 79, 10.1177/154405910508400114

Paula-Silva, 2009, TNF-alpha promotes an odontoblastic phenotype in dental pulp cells, J Dent Res, 88, 339, 10.1177/0022034509334070

Byers, 1990, Multiple functions for Ngf receptor in developing, aging and injured rat teeth are suggested by epithelial, mesenchymal and neural immunoreactivity, Development, 109, 461, 10.1242/dev.109.2.461

Magloire, 2001, Molecular regulation of odontoblast activity under dentin injury, Adv Dent Res, 15, 46, 10.1177/08959374010150011201

Nosrat, 1998, NGF, BDNF, NT3, NT4 and GDNF in tooth development, Eur J Oral Sci, 106, 94, 10.1111/j.1600-0722.1998.tb02158.x

Fristad, 2010, Inflammatory nerve responses in the dental pulp, Endod Top, 17, 12, 10.1111/j.1601-1546.2010.00247.x

Haug, 2006, Modulation of dental inflammation by the sympathetic nervous system, J Dent Res, 85, 488, 10.1177/154405910608500602

Caviedes-Bucheli, 2008, Neuropeptides in dental pulp: the silent protagonists, J Endod, 34, 773, 10.1016/j.joen.2008.03.010

El Karim, 2009, Neuropeptides regulate expression of angiogenic growth factors in human dental pulp fibroblasts, J Endod, 35, 829, 10.1016/j.joen.2009.03.005

Kline, 2009, Effects of calcitonin, calcitonin gene related peptide, human recombinant bone morphogenetic protein-2, and parathyroid hormone-related protein on endodontically treated ferret canines, J Endod, 35, 866, 10.1016/j.joen.2009.03.045

Airaksinen, 2002, The GDNF family: signalling, biological functions and therapeutic value, Nat Rev Neurosci, 3, 383, 10.1038/nrn812

Chao, 2006, Neurotrophin signalling in health and disease, Clin Sci, 110, 167, 10.1042/CS20050163

Bauer, 2007, The neuropoietic cytokine family in development, plasticity, disease and injury, Nat Rev Neurosci, 8, 221, 10.1038/nrn2054

Fiore, 2009, Nerve growth factor as a signaling molecule for nerve cells and also for the neuroendocrine–immune systems, Rev Neurosci, 20, 133, 10.1515/REVNEURO.2009.20.2.133

Woodnutt, 2000, Neurotrophin receptors and nerve growth factor are differentially expressed in adjacent nonneuronal cells of normal and injured tooth pulp, Cell Tissue Res, 299, 225, 10.1007/s004410050020

Amano, 1999, Nerve growth factor (NGF) supports tooth morphogenesis in mouse first branchial arch explants, Dev Dyn, 216, 299, 10.1002/(SICI)1097-0177(199911)216:3<299::AID-DVDY8>3.0.CO;2-B

Arany, 2009, Nerve growth factor promotes differentiation of odontoblast-like cells, J Cell Biochem, 106, 539, 10.1002/jcb.22006

Mitsiadis, 1995, Neurotrophins in odontogenesis, Int J Dev Biol, 39, 195

Grills, 1998, Immunohistochemical localization of nerve growth factor in fractured and unfractured rat bone, Acta Orthop Scand, 69, 415, 10.3109/17453679808999059

Kanato, 2009, Complex formation of a brain-derived neurotrophic factor and glycosaminoglycans, Biosci Biotechnol Biochem, 73, 2735, 10.1271/bbb.90637

Nosrat, 2002, Expression patterns of neurotrophic factor mRNAs in developing human teeth, Cell Tissue Res, 310, 177, 10.1007/s00441-002-0618-8

de Vicente, 2002, Impaired dental cytodifferentiation in glial cell-line derived growth factor (GDNF) deficient mice, Ann Anat, 184, 85, 10.1016/S0940-9602(02)80041-3

Rider, 2006, Heparin/heparan sulphate binding in the TGF-beta cytokine superfamily, Biochem Soc Trans, 34, 458, 10.1042/BST0340458

Thomas, 1975, Identification and estimation of plasma proteins in human dentine, Arch Oral Biol, 20, 217, 10.1016/0003-9969(75)90012-6

Okamura, 1979, Plasma components in deep lesions of human carious dentin, J Dent Res, 58, 2010, 10.1177/00220345790580101101

Arandjelovic, 2003, Growth factor-binding sequence in human alpha2-macroglobulin targets the receptor-binding site in transforming growth factor-beta, Biochemistry, 42, 6121, 10.1021/bi0342158

Liu, 2009, Distinctive anabolic roles of 1,25-dihydroxyvitamin D3 and parathyroid hormone in teeth and mandible versus long bones, J Endocrinol, 203, 203, 10.1677/JOE-09-0247

Sugiyama, 2010, Functional adaptation to mechanical loading in both cortical and cancellous bone is controlled locally and is confined to the loaded bones, Bone, 46, 314, 10.1016/j.bone.2009.08.054

Allard, 2006, Voltage-gated sodium channels confer excitability to human odontoblasts: possible role in tooth pain transmission, J Biol Chem, 281, 29002, 10.1074/jbc.M601020200

Magloire, 2009, Odontoblast: a mechano-sensory cell, J Exp Zool B Mol Dev Evol, 15, 416, 10.1002/jez.b.21264

Dhopatkar, 2005, A novel in vitro culture model to investigate the reaction of the dentine–pulp complex to orthodontic force, J Orthod, 32, 122, 10.1179/146531205225020979

Lu, 2007, DMP-1 targeted Cre expression in odontoblasts and osteocytes, J Dent Res, 86, 320, 10.1177/154405910708600404

Qin, 2002, The expression of dentin sialophosphoprotein gene in bone, J Dent Res, 81, 392, 10.1177/154405910208100607

Xiao, 2001, Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP, Nat Genet, 27, 201, 10.1038/84848

Urist, 1965, Bone: formation by autoinduction, Science, 150, 893, 10.1126/science.150.3698.893

Urist, 1979, Preservation and biodegradation of the morphogenetic property of bone matrix, J Theor Biol, 38, 257

Reddi, 1997, Bone morphogenetic proteins: an unconventional approach to isolation of first mammalian morphogens, Cytokine Growth Factor Rev, 8, 11, 10.1016/S1359-6101(96)00049-4

Hauschka, 1986, Growth factors in bone matrix, J Biol Chem, 261, 12665, 10.1016/S0021-9258(18)67143-1

Mohan, 1987, Identification and quantification of four distinct growth factors stored in human bone matrix, J Bone Miner Res, 44A

Schultz, 2009, Interactions between extracellular matrix and growth factors in wound healing, Wound Repair Regen, 17, 153, 10.1111/j.1524-475X.2009.00466.x

Hynes, 2009, The extracellular matrix: not just pretty fibrils, Science, 326, 1216, 10.1126/science.1176009

Smith, 2001, Trans-dentinal stimulation of tertiary dentinogenesis, Adv Dent Res, 15, 51, 10.1177/08959374010150011301

Tziafas, 2000, Designing new treatment strategies in vital pulp therapy, J Dent, 28, 77, 10.1016/S0300-5712(99)00047-0

Dreyfuss, 2009, Heparan sulfate proteoglycans: structure, protein interactions and cell signaling, An Acad Bras Cienc, 81, 409, 10.1590/S0001-37652009000300007

Kreuger, 2006, Interactions between heparan sulfate and proteins: the concept of specificity, J Cell Biol, 174, 323, 10.1083/jcb.200604035

Smith, 1998, Transforming growth factor-beta 1 (TGF-beta 1) in dentine matrix—ligand activation and receptor expression, Eur J Oral Sci, 106, 179, 10.1111/j.1600-0722.1998.tb02173.x

Baker, 2009, TGF-beta/extracellular matrix interactions in dentin matrix: a role in regulating sequestration and protection of bioactivity, Calcif Tissue Int, 85, 66, 10.1007/s00223-009-9248-4

Gotz, 2006, Immunohistochemical localization of components of the insulin-like growth factor system in human permanent teeth, Arch Oral Biol, 51, 387, 10.1016/j.archoralbio.2005.10.005

Arai, 1996, Binding of insulin-like growth factor (IGF) I or II to IGF-binding protein-2 enables it to bind to heparin and extracellular matrix, Endocrinology, 137, 4571, 10.1210/endo.137.11.8895319

Kuang, 2006, Structure, dynamics and heparin binding of the C-terminal domain of insulin-like growth factor-binding protein-2 (IGFBP-2), J Mol Biol, 364, 690, 10.1016/j.jmb.2006.09.006

Mohan, 2002, IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms, J Endocrinol, 175, 19, 10.1677/joe.0.1750019

Clark, 1998, Transforming growth factor-beta (TGF-beta), Int J Biochem Cell Biol, 30, 293, 10.1016/S1357-2725(97)00128-3

Hyytiainen, 2004, Latent TGF-beta binding proteins: extracellular matrix association and roles in TGF-beta activation, Crit Rev Clin Lab Sci, 41, 233, 10.1080/10408360490460933

Larrain, 2000, BMP-binding modules in chordin: a model for signalling regulation in the extracellular space, Development, 127, 821, 10.1242/dev.127.4.821

Zhu, 1999, Type IIA procollagen containing the cysteine-rich amino propeptide is deposited in the extracellular matrix of prechondrogenic tissue and binds to TGF-beta 1 and BMP-2, J Cell Biol, 144, 1069, 10.1083/jcb.144.5.1069

Rahman, 2005, Novel hepatocyte growth factor (HGF) binding domains on fibronectin and vitronectin coordinate a distinct and amplified Met-integrin induced signalling pathway in endothelial cells, BMC Cell Biol, 6, 8, 10.1186/1471-2121-6-8

Wijelath, 2006, Heparin-II domain of fibronectin is a vascular endothelial growth factor-binding domain—enhancement of VEGF biological activity by a singular growth factor/matrix protein synergism, Circ Res, 99, 853, 10.1161/01.RES.0000246849.17887.66

Franitza, 2000, TNF-alpha associated with extracellular matrix fibronectin provides a stop signal for chemotactically migrating T cells, J Immunol, 165, 2738, 10.4049/jimmunol.165.5.2738

Somasundaram, 2000, Collagens serve as an extracellular store of bioactive interleukin 2, J Biol Chem, 275, 38170, 10.1074/jbc.M006616200

Paralkar, 1991, Transforming growth-factor-beta type-1 binds to collagen-IV of basement-membrane matrix—implications for development, Dev Biol, 143, 303, 10.1016/0012-1606(91)90081-D

Paralkar, 1990, Interaction of osteogenin, a heparin binding bone morphogenetic protein, with type-IV collagen, J Biol Chem, 265, 17281, 10.1016/S0021-9258(17)44900-3

Graham, 2006, The effect of calcium hydroxide on solubilisation of bi-active dentin matrix components, Biomaterials, 27, 2865, 10.1016/j.biomaterials.2005.12.020

Tomson, 2007, Dissolution of bio-active dentine matrix components by mineral trioxide aggregate, J Dent, 35, 636, 10.1016/j.jdent.2007.04.008

Goldberg, 2004, Cells and extracellular matrices of dentin and pulp: a biological basis for repair and tissue engineering, Crit Rev Oral Biol Med, 15, 13, 10.1177/154411130401500103

Moghaddame-Jafari, 2005, Effect of ProRoot MTA on pulp cell apoptosis and proliferation in vitro, J Endod, 31, 387, 10.1097/01.don.0000145423.89539.d7

Kuratate, 2008, Immunohistochemical analysis of nestin, osteopontin, and proliferating cells in the reparative process of exposed dental pulp capped with mineral trioxide aggregate, J Endod, 34, 970, 10.1016/j.joen.2008.03.021

Masuda-Murakami, 2010, Effects of mineral trioxide aggregate on the differentiation of rat dental pulp cells, Acta Histochem, 112, 452, 10.1016/j.acthis.2009.05.001

Simon, 2008, Evaluation of a new laboratory model for pulp healing: preliminary study, Int Endod J, 41, 781, 10.1111/j.1365-2591.2008.01433.x

Dung, 1995, Effect of lactic acid and proteolytic enzymes on the release of organic matrix components from human root dentin, Caries Res, 29, 483, 10.1159/000262119

Pashley, 2004, Collagen degradation by host-derived enzymes during aging, J Dent Res, 83, 216, 10.1177/154405910408300306

Tay, 2006, Self-etching adhesives increase collagenolytic activity in radicular dentin, J Endod, 32, 862, 10.1016/j.joen.2006.04.005

Mazzoni, 2007, Zymographic analysis and characterization of MMP-2 and -9 forms in human sound dentin, J Dent Res, 86, 436, 10.1177/154405910708600509

Mazzoni, 2006, Reactivation of inactivated endogenous proteolytic activities in phosphoric acid-etched dentin by etch-and-rinse adhesives, Biomaterials, 27, 4470, 10.1016/j.biomaterials.2006.01.040

Smith, 1998, Solubilisation of TGF-β1 by dentine conditioning agents, J Dent Res, 77, 1034

Ferracane, 2010, Dentin matrix proteins solubilized by solutions relevant to dentin adhesives, J Dent Res, 89B, 148

Hebling, 1999, Biocompatibility of an adhesive system applied to exposed human dental pulp, J Endod, 25, 676, 10.1016/S0099-2399(99)80354-9

Pereira, 2000, Human pulpal response to direct pulp capping with an adhesive system, Am J Dent, 13, 139

Mantellini, 2003, Adhesive resin induces apoptosis and cell-cycle arrest of pulp cells, J Dent Res, 82, 592, 10.1177/154405910308200804

Do Nascimiento, 2000, Biocompatibility of a resin-modified glass ionomer cement applied as pulp capping in human teeth, Am J Dent, 13, 28

Holland, 1999, Reaction of dogs’ teeth to root canal filling with mineral trioxide aggregate or a glass ionomer sealer, J Endod, 25, 728, 10.1016/S0099-2399(99)80118-6

Six, 2000, In vivo study of the pulp reaction to Fuji IX, a glass ionomer cement, J Dent, 28, 413, 10.1016/S0300-5712(00)00015-4

Mousavinasab, 2008, Histopathology study on pulp response to glass ionomers in human teeth, J Calif Dent Assoc, 36, 51, 10.1080/19424396.2008.12221464

Massara, 2002, Atraumatic restorative treatment: clinical, ultrastructural and chemical analysis, Caries Res, 36, 430, 10.1159/000066534

Ngo, 2006, Chemical exchange between glass-ionomer restorations and residual carious dentine in permanent molars: an in vivo study, J Dent, 34, 608, 10.1016/j.jdent.2005.12.012

Yli-Urpo, 2005, Compound changes and tooth mineralization effects of glass ionomer cements containing bioactive glass (S53P4), an in vivo study, Biomaterials, 26, 5934, 10.1016/j.biomaterials.2005.03.008

Smith, 2008, Dental regeneration and materials—a partnership, Clin Oral Investig, 12, 103, 10.1007/s00784-008-0189-5

Smith, 2003, Vitality of the dentin–pulp complex in health and disease: growth factors as key mediators, J Dent Educ, 67, 678, 10.1002/j.0022-0337.2003.67.6.tb03668.x

Ferracane, 2010, Can interaction of materials with the dentin–pulp complex contribute to dentin regeneration?, Odontology, 98, 2, 10.1007/s10266-009-0116-5

Smith, 1984, Proteolytic activity of rabbit incisor dentine, Arch Oral Biol, 29, 1049, 10.1016/0003-9969(84)90153-5

Martin-De Las Heras, 2000, The matrix metalloproteinase gelatinase A in human dentine, Arch Oral Biol, 45, 757, 10.1016/S0003-9969(00)00052-2

Sulkala, 2002, The localization of matrix metalloproteinase-20 (MMP-20, enamelysin) in mature human teeth, J Dent Res, 81, 603, 10.1177/154405910208100905

Sulkala, 2004, Matrix metalloproteinase-13 (MMP-13, collagenase-3) is highly expressed in human tooth pulp, Connect Tissue Res, 45, 231, 10.1080/03008200490885788

Sulkala, 2007, Matrix metalloproteinase-8 (MMP-8) is the major collagenase in human dentin, Arch Oral Biol, 52, 121, 10.1016/j.archoralbio.2006.08.009

Yamakoshi, 2009, Dentinogenesis and dentin sialophosphoprotein (DSPP), J Oral Biosci, 51, 134, 10.2330/joralbiosci.51.134

Chaussain, 2009, MMP2-cleavage of DMP1 generates a bioactive peptide promoting differentiation of dental pulp stem/progenitor cell, Eur Cell Mater, 18, 84, 10.22203/eCM.v018a08

Fedarko, 2004, Three small integrin binding ligand N-linked glycoproteins (SIBLINGs) bind and activate specific matrix metalloproteinases, FASEB J, 18, 734, 10.1096/fj.03-0966fje

Hall, 1999, Stromelysin-1 (MMP-3) in forming enamel and predentine in rat incisor-coordinated distribution with proteoglycans suggests a functional role, Histochem J, 31, 761, 10.1023/A:1003945902473

Martínez, 2004, Matrix metalloproteinase-2 cleavage of adrenomedullin produces a vasoconstrictor out of a vasodilator, Biochem J, 383, 413, 10.1042/BJ20040920

Dallas, 2002, Proteolysis of latent transforming growth factor-beta (TGF-beta)-binding protein-1 by osteoclasts. A cellular mechanism for release of TGF-beta from bone matrix, J Biol Chem, 277, 21352, 10.1074/jbc.M111663200

Miyamoto, 2004, Matrix metalloproteinase-7 facilitates insulin-like growth factor bioavailability through its proteinase activity on insulin-like growth factor binding protein 3, Cancer Res, 64, 665, 10.1158/0008-5472.CAN-03-1916

Zheng, 2009, Matrix metalloproteinase-3 accelerates wound healing following dental pulp injury, Am J Pathol, 175, 1905, 10.2353/ajpath.2009.080705

Joo, 2008, Matrix metalloproteinase (MMP) and TGF beta 1-stimulated cell migration in skin and cornea wound healing, Cell Adhes Migr, 2, 252, 10.4161/cam.2.4.6772

Heywood, 1984, The ultrastructure of the rat incisor odontoblast in organ culture, Arch Oral Biol, 29, 327, 10.1016/0003-9969(84)90107-9

Smith, 2005, Dentine regeneration: the role of stem cells and molecular signaling, Oral Biosci Med, 2, 127

Zhang, 2011, Angiogenic activity of dentin matrix components, J Endod, 37, 26, 10.1016/j.joen.2010.08.042

Bjørndal, 1998, A quantitative light microscopic study of the odontoblast and subodontoblastic reactions to active and arrested enamel caries without cavitation, Caries Res, 32, 59, 10.1159/000016431

Bjørndal, 1999, A light microscopic study of odontoblastic and non-odontoblastic cells involved in tertiary dentinogenesis in well-defined cavitated carious lesions, Caries Res, 33, 50, 10.1159/000016495

Bjørndal, 2001, Presence or absence of tertiary dentinogenesis in relation to caries progression, Adv Dent Res, 15, 80, 10.1177/08959374010150012101

Smith, 1995, Reactionary dentinogenesis, Int J Dev Biol, 39, 273

Kwon, 2010, Transforming growth factor beta1-induced heat shock protein 27 activation promotes migration of mouse dental papilla-derived MDPC-23 cells, J Endod, 36, 1332, 10.1016/j.joen.2010.04.010

Brenmoehl, 2009, Transforming growth factor-beta 1 induces intestinal myofibroblast differentiation and modulates their migration, World J Gastroenterol, 15, 1431, 10.3748/wjg.15.1431

Macdonald, 2007, Cellular delivery of TGFbeta1 promotes osteoinductive signalling for bone regeneration, J Tissue Eng Regen Med, 1, 314, 10.1002/term.31

Howard, 2010, Dental pulp stem cell migration, J Endod, 36, 1963, 10.1016/j.joen.2010.08.046

He, 2004, TGF-β activated Smad signalling leads to a Smad3-mediated down-regulation of DSPP in an odontoblast cell line, Arch Oral Biol, 49, 911, 10.1016/j.archoralbio.2004.05.005

Ruch, 1995, Odontoblast differentiation, Int J Dev Biol, 39, 51

Begue-Kirn, 1992, Effects of dentin proteins, transforming growth factor β1 (TGFβ1) and bone morphogenetic protein 2 (BMP2) on the differentiation of odontoblasts in vitro, Int J Dev Biol, 36, 491

Begue-Kirn, 1994, Comparative analysis of TGFβs, BMPs, IGF, msxs, fibronectin, osteonectin and bone sialoprotein gene expressions during normal and in vitro induced odontoblast differentiation, Int J Dev Biol, 38, 405

Smith, 1990, In vivo morphogenetic activity of dentine matrix proteins, J Biol Buccale, 18, 123

Anneroth, 1972, The effect of allogenic demineralised dentin as a pulp capping agent in Java monkeys, Odontol Revy, 23, 315

Sloan, 1999, Stimulation of the dentine–pulp complex of rat incisor teeth by transforming growth factor-β isoforms 1–3 in vitro, Arch Oral Biol, 44, 149, 10.1016/S0003-9969(98)00106-X

Melin, 2000, Effects of TGFbeta1 on dental pulp cells in cultured human tooth slices, J Dent Res, 79, 1689, 10.1177/00220345000790090901

Hu, 1998, Reparative dentin formation in rat molars after direct pulp capping with growth factors, J Endod, 24, 744, 10.1016/S0099-2399(98)80166-0

Shao, 2011, β-Catenin and Rho GTPases as downstream targets of TGF-β1 during pulp repair, Cell Biol Int, 35, 105, 10.1042/CBI20100114

Scheller, 2008, Wnt/β-catenin inhibits dental pulp stem cell differentiation, J Dent Res, 87, 126, 10.1177/154405910808700206

Couve, 1986, Ultrastructural changes during the life cycle of human odontoblasts, Arch Oral Biol, 31, 643, 10.1016/0003-9969(86)90093-2

Romagnoli, 1990, The crown odontoblasts of rat molars from primary dentinogenesis to complete eruption, J Dent Res, 69, 1857, 10.1177/00220345900690121301

Botero, 2010, MAPK signaling is required for LPS-induced VEGF in pulp stem cells, J Dent Res, 89, 264, 10.1177/0022034509357556

Cordeiro, 2008, Dental pulp tissue engineering with stem cells from exfoliated deciduous teeth, J Endod, 34, 962, 10.1016/j.joen.2008.04.009