Dengue Hemorrhagic Fever: A State-of-the-Art Review Focused in Pulmonary Involvement

Renata Rocha de Almeida1, Bernardo Paim1, Solange Artimos de Oliveira2, Arthur Soares Souza3, Antônio Carlos Portugal Gomes4, Dante Luiz Escuissato5, Gláucia Zanetti1, Edson Marchiori1,2,6
1Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
2Fluminense Federal University, Rio De Janeiro, Brazil
3Medical School of Rio Preto and Ultra X, São José do Rio Preto, Brazil
4Hospital Beneficência Portuguesa and Med Imagem, São Paulo, Brazil
5Federal University of Paraná, Curitiba, Brazil
6Petrópolis, Rio De Janeiro, Brazil

Tóm tắt

Dengue fever is an arboviral disease transmitted to humans through the bites of infected female Aedes mosquitoes. Dengue virus is a member of the Flaviviridae family, and human infection can be caused by any of the four antigenically distinct serotypes (DENV 1–4). The infection has become recognized as the most important and prevalent arboviral disease in humans, endemic in almost 100 countries worldwide. Nearly 3 billion people live in areas with transmission risk. Autochthonous transmission of the virus in previously disease-free areas, increased incidence in endemic areas, and epidemic resurgence in controlled regions could increase the risk of contracting more severe forms of the disease, such as dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS). Symptomatic dengue virus infection can present with a wide range of clinical manifestations, from mild fever to life-threatening DSS. Thoracic complications may manifest as pleural effusion, pneumonitis, non-cardiogenic pulmonary edema, and hemorrhage/hemoptysis. No vaccine is currently available and no specific treatment for dengue fever exists, but prevention and prompt management of complications in patients with DHF can help reduce mortality. This review describes the main clinical, pathological, and imaging findings of thoracic involvement in DHF.

Tài liệu tham khảo

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