Dendritic epidermal T cells regulate skin homeostasis through local production of insulin-like growth factor 1
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Edmondson, S.R., Thumiger, S.P., Werther, G.A. & Wraight, C.J. Epidermal homeostasis: the role of the growth hormone and insulin-like growth factor systems. Endocr. Rev. 24, 737–764 (2003).
Alonso, L. & Fuchs, E. Stem cells of the skin epithelium. Proc. Natl. Acad. Sci. USA 100, 11830–11835 (2003).
Lew, W., Bowcock, A.M. & Krueger, J.G. Psoriasis vulgaris: cutaneous lymphoid tissue supports T-cell activation and 'type 1' inflammatory gene expression. Trends Immunol. 25, 295–305 (2004).
Girardi, M. et al. Resident skin-specific γδ T cells provide local, nonredundant regulation of cutaneous inflammation. J. Exp. Med. 195, 855–867 (2002).
Girardi, M. et al. The distinct contributions of murine T cell receptor (TCR) γδ+ and TCR αβ+ T cells to different stages of chemically induced skin cancer. J. Exp. Med. 198, 747–755 (2003).
Asarnow, D.M. et al. Limited diversity of γδ antigen receptor genes of Thy-1+ dendritic epidermal cells. Cell 55, 837–847 (1988).
Havran, W.L., Chien, Y.H. & Allison, J.P. Recognition of self antigens by skin-derived T cells with invariant γδ antigen receptors. Science 252, 1430–1432 (1991).
Boismenu, R. & Havran, W.L. Modulation of epithelial cell growth by intraepithelial γδ T cells. Science 266, 1253–1255 (1994).
Boismenu, R., Feng, L., Xia, Y.Y., Chang, J.C. & Havran, W.L. Chemokine expression by intraepithelial γδ T cells. Implications for the recruitment of inflammatory cells to damaged epithelia. J. Immunol. 157, 985–992 (1996).
Silha, J.V. & Murphy, L.J. Insights from insulin-like growth factor binding protein transgenic mice. Endocrinology 143, 3711–3714 (2002).
Vincent, A.M. & Feldman, E.L. Control of cell survival by IGF signaling pathways. Growth Horm. IGF Res. 12, 193–197 (2002).
Dorshkind, K. & Horseman, N.D. The roles of prolactin, growth hormone, insulin-like growth factor-I, and thyroid hormones in lymphocyte development and function: insights from genetic models of hormone and hormone receptor deficiency. Endocr. Rev. 21, 292–312 (2000).
Stentz, F.B. & Kitabchi, A.E. De novo emergence of growth factor receptors in activated human CD4+ and CD8+ T lymphocytes. Metabolism 53, 117–122 (2004).
DiGiovanni, J. et al. Constitutive expression of insulin-like growth factor-1 in epidermal basal cells of transgenic mice leads to spontaneous tumor promotion. Cancer Res. 60, 1561–1570 (2000).
Liu, J.P., Baker, J., Perkins, A.S., Robertson, E.J. & Efstratiadis, A. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 75, 59–72 (1993).
Rho, O. et al. Altered expression of insulin-like growth factor I and its receptor during multistage carcinogenesis in mouse skin. Mol. Carcinog. 17, 62–69 (1996).
Brown, D.L., Kane, C.D., Chernausek, S.D. & Greenhalgh, D.G. Differential expression and localization of insulin-like growth factors I and II in cutaneous wounds of diabetic and nondiabetic mice. Am. J. Pathol. 151, 715–724 (1997).
Tavakkol, A., Varani, J., Elder, J.T. & Zouboulis, C.C. Maintenance of human skin in organ culture: role for insulin-like growth factor-1 receptor and epidermal growth factor receptor. Arch. Dermatol. Res. 291, 643–651 (1999).
Kuhn, C., Hurwitz, S.A., Kumar, M.G., Cotton, J. & Spandau, D.F. Activation of the insulin-like growth factor-1 receptor promotes the survival of human keratinocytes following ultraviolet B irradiation. Int. J. Cancer 80, 431–438 (1999).
Walsh, P.T., Smith, L.M. & O'Connor, R. Insulin-like growth factor-1 activates Akt and Jun N-terminal kinases (JNKs) in promoting the survival of T lymphocytes. Immunology 107, 461–471 (2002).
Jameson, J.M., Cauvi, G., Witherden, D.A. & Havran, W.L. A keratinocyte-responsive γδ TCR is necessary for dendritic epidermal T cell activation by damaged keratinocytes and maintenance in the epidermis. J. Immunol. 172, 3573–3579 (2004).
Bigby, M. et al. Most γδ T cells develop normally in the absence of MHC class II molecules. J. Immunol. 151, 4465–4475 (1993).
Mombaerts, P. et al. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68, 869–877 (1992).
Koshizuka, S. et al. The beneficial effects of recombinant human insulin-like growth factor-I (IGF-I) on wound healing in severely wounded senescent mice. Surg. Today 27, 946–952 (1997).
Jeschke, M.G., Schubert, T. & Klein, D. Exogenous liposomal IGF-I cDNA gene transfer leads to endogenous cellular and physiological responses in an acute wound. Am. J. Physiol. Regul. Integr. Comp. Physiol. 286, R958–R966 (2004).
Barbieri, M., Bonafe, M., Franceschi, C. & Paolisso, G. Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans. Am. J. Physiol. Endocrinol. Metab. 285, E1064–E1071 (2003).
Shires, J., Theodoridis, E. & Hayday, A.C. Biological insights into TCR γδ+ and TCR αβ+ intraepithelial lymphocytes provided by serial analysis of gene expression (SAGE). Immunity 15, 419–434 (2001).
Brocardo, M.G. et al. Early effects of insulin-like growth factor-1 in activated human T lymphocytes. J. Leukoc. Biol. 70, 297–305 (2001).
Pifer, J., Stephan, R.P., Lill-Elghanian, D.A., Le, P.T. & Witte, P.L. Role of stromal cells and their products in protecting young and aged B-lineage precursors from dexamethasone-induced apoptosis. Mech. Ageing Dev. 124, 207–218 (2003).
Su, H.-Y. et al. Mouse keratinocytes express c98, a novel gene homologous to bcl-2, that is stimulated by insulin-like growth factor 1 and prevents dexamethasone-induced apoptosis. Biochimica et Biophysica Acta (BBA) - Gene Struct. Exp. 1676, 127–137 (2004).
Ghofrani, A., Holler, D., Schuhmann, K., Saldern, S. & Messmer, B.J. The influence of systemic growth hormone administration on the healing time of skin graft donor sites in a pig model. Plast. Reconstr. Surg. 104, 470–475 (1999).
Bitar, M.S. Insulin and glucocorticoid-dependent suppression of the IGF-I system in diabetic wounds. Surgery 127, 687–695 (2000).
Blakytny, R., Jude, E.B., Martin Gibson, J., Boulton, A.J. & Ferguson, M.W. Lack of insulin-like growth factor 1 (IGF1) in the basal keratinocyte layer of diabetic skin and diabetic foot ulcers. J. Pathol. 190, 589–594 (2000).
Guo, L., Yu, Q.C. & Fuchs, E. Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice. EMBO J. 12, 973–986 (1993).
Revest, J.M., Suniara, R.K., Kerr, K., Owen, J.J. & Dickson, C. Development of the thymus requires signaling through the fibroblast growth factor receptor R2-IIIb. J. Immunol. 167, 1954–1961 (2001).
Werner, S. et al. The function of KGF in morphogenesis of epithelium and reepithelialization of wounds. Science 266, 819–822 (1994).
Nissley, S.P. & Rechler, M.M. Somatomedin/insulin-like growth factor tissue receptors. Clin. Endocrinol. Metab. 13, 43–67 (1984).
Finch, P.W., Rubin, J.S., Miki, T., Ron, D. & Aaronson, S.A. Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. Science 245, 752–755 (1989).
De Moerlooze, L. et al. An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis. Development 127, 483–492 (2000).
Guo, L., Degenstein, L. & Fuchs, E. Keratinocyte growth factor is required for hair development but not for wound healing. Genes Dev. 10, 165–175 (1996).