Dendritic cell subsets and immune regulation in the lung

Seminars in Immunology - Tập 17 - Trang 295-303 - 2005
Hendrik Jan de Heer1, Hamida Hammad1, Mirjam Kool1, Bart N. Lambrecht1
1Department of Pulmonary Medicine, Erasmus University Medical Center, Dr. Molewaterplein 50, Room Ee2251b, 3015 GE Rotterdam, The Netherlands

Tài liệu tham khảo

Maldonado-Lopez, 1999, CD8alpha+ and CD8alpha− subclasses of dendritic cells direct the development of distinct T helper cells in vivo, J Exp Med, 189, 587, 10.1084/jem.189.3.587 Rissoan, 1999, Reciprocal control of T helper cell and dendritic cell differentiation, Science, 283, 1183, 10.1126/science.283.5405.1183 Kapsenberg, 2003, Dendritic-cell control of pathogen-driven T-cell polarization, Nat Rev Immunol, 3, 984, 10.1038/nri1246 Vremec, 2000, CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen, J Immunol, 164, 2978, 10.4049/jimmunol.164.6.2978 De Smedt, 1996, Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo, J Exp Med, 184, 1413, 10.1084/jem.184.4.1413 Reis e Sousa, 1997, In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas, J Exp Med, 186, 1819, 10.1084/jem.186.11.1819 Vremec, 1997, Dendritic cell subtypes in mouse lymphoid organs: cross-correlation of surface markers, changes with incubation, and differences among thymus, spleen, and lymph nodes, J Immunol, 159, 565, 10.4049/jimmunol.159.2.565 Henri, 2001, The dendritic cell populations of mouse lymph nodes, J Immunol, 167, 741, 10.4049/jimmunol.167.2.741 Wu, 1996, Thymic dendritic cell precursors: relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny, J Exp Med, 184, 903, 10.1084/jem.184.3.903 Traver, 2000, Development of CD8alpha-positive dendritic cells from a common myeloid progenitor, Science, 290, 2152, 10.1126/science.290.5499.2152 Wu, 2001, Development of thymic and splenic dendritic cell populations from different hemopoietic precursors, Blood, 98, 3376, 10.1182/blood.V98.12.3376 O’Garra, 2004, Are dendritic cells afraid of commitment?, Nat Immunol, 5, 1206, 10.1038/ni1204-1206 del Hoyo, 2002, Characterization of a common precursor population for dendritic cells, Nature, 415, 1043, 10.1038/4151043a Bruno, 2001, Mouse pre-immunocytes as non-proliferating multipotent precursors of macrophages, interferon-producing cells, CD8alpha(+) and CD8alpha(−) dendritic cells, Eur J Immunol, 31, 3403, 10.1002/1521-4141(200111)31:11<3403::AID-IMMU3403>3.0.CO;2-T D’Amico, 2003, The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3, J Exp Med, 198, 293, 10.1084/jem.20030107 Nikolic, 2002, A subfraction of B220(+) cells in murine bone marrow and spleen does not belong to the B cell lineage but has dendritic cell characteristics, Eur J Immunol, 32, 686, 10.1002/1521-4141(200203)32:3<686::AID-IMMU686>3.0.CO;2-I Nakano, 2001, CD11c(+)B220(+)Gr-1(+) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells, J Exp Med, 194, 1171, 10.1084/jem.194.8.1171 Asselin-Paturel, 2001, Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology, Nat Immunol, 2, 1144, 10.1038/ni736 Bjorck, 2001, Isolation and characterization of plasmacytoid dendritic cells from Flt3 ligand and granulocyte-macrophage colony-stimulating factor-treated mice, Blood, 98, 3520, 10.1182/blood.V98.13.3520 Blasius, 2004, A cell-surface molecule selectively expressed on murine natural interferon-producing cells that blocks secretion of interferon-alpha, Blood, 103, 4201, 10.1182/blood-2003-09-3108 O’Keeffe, 2002, Mouse plasmacytoid cells: long-lived cells, heterogeneous in surface phenotype and function, that differentiate into CD8(+) dendritic cells only after microbial stimulus, J Exp Med, 196, 1307, 10.1084/jem.20021031 McIlroy, 1995, Infection frequency of dendritic cells and CD4+ T lymphocytes in spleens of human immunodeficiency virus-positive patients, J Virol, 69, 4737, 10.1128/JVI.69.8.4737-4745.1995 Hart, 1997, Dendritic cells: unique leukocyte populations which control the primary immune response, Blood, 90, 3245, 10.1182/blood.V90.9.3245 Caux, 1992, GM-CSF and TNF-alpha cooperate in the generation of dendritic Langerhans cells, Nature, 360, 258, 10.1038/360258a0 Sallusto, 1994, Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha, J Exp Med, 179, 1109, 10.1084/jem.179.4.1109 Gong, 1992, Intraepithelial airway dendritic cells: a distinct subset of pulmonary dendritic cells obtained by microdissection, J Exp Med, 175, 797, 10.1084/jem.175.3.797 Holt, 1994, Origin and steady-state turnover of class II MHC-bearing dendritic cells in the epithelium of the conducting airways, J Immunol, 153, 256, 10.4049/jimmunol.153.1.256 Holt, 1991, Immunoregulation of asthma: control of T-lymphocyte activation in the respiratory tract, Eur Respir J Suppl, 13, 6s Pollard, 1990, Characterization of murine lung dendritic cells: similarities to Langerhans cells and thymic dendritic cells, J Exp Med, 172, 159, 10.1084/jem.172.1.159 Sertl, 1986, Dendritic cells with antigen-presenting capability reside in airway epithelium, lung parenchyma, and visceral pleura, J Exp Med, 163, 436, 10.1084/jem.163.2.436 Suda, 1998, Dendritic cell precursors are enriched in the vascular compartment of the lung, Am J Respir Cell Mol Biol, 19, 728, 10.1165/ajrcmb.19.5.3214 Huh, 2003, Bidirectional interactions between antigen-bearing respiratory tract dendritic cells (DCs) and T cells precede the late phase reaction in experimental asthma: DC activation occurs in the airway mucosa but not in the lung parenchyma, J Exp Med, 198, 19, 10.1084/jem.20021328 Lambrecht, 1998, Dendritic cells are required for the development of chronic eosinophilic airway inflammation in response to inhaled antigen in sensitized mice, J Immunol, 160, 4090, 10.4049/jimmunol.160.8.4090 Vermaelen, 2004, Accurate and simple discrimination of mouse pulmonary dendritic cell and macrophage populations by flow cytometry: methodology and new insights, Cytometry, 61A, 170, 10.1002/cyto.a.20064 Schon-Hegrad, 1991, Studies on the density, distribution, and surface phenotype of intraepithelial class II major histocompatibility complex antigen (Ia)-bearing dendritic cells (DC) in the conducting airways, J Exp Med, 173, 1345, 10.1084/jem.173.6.1345 Jahnsen, 2001, Rapid dendritic cell recruitment to the bronchial mucosa of patients with atopic asthma in response to local allergen challenge, Thorax, 56, 823, 10.1136/thorax.56.11.823 van Haarst, 1994, Dendritic cells and their precursors isolated from human bronchoalveolar lavage: immunocytologic and functional properties, Am J Respir Cell Mol Biol, 11, 344, 10.1165/ajrcmb.11.3.8086170 Power, 1997, Cloning and characterization of a specific receptor for the novel CC chemokine MIP-3alpha from lung dendritic cells, J Exp Med, 186, 825, 10.1084/jem.186.6.825 Reibman, 2003, Airway epithelial cells release MIP-3alpha/CCL20 in response to cytokines and ambient particulate matter, Am J Respir Cell Mol Biol, 28, 648, 10.1165/rcmb.2002-0095OC De Heer, 2004, Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen, J Exp Med, 200, 89, 10.1084/jem.20040035 Stumbles, 1998, Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity, J Exp Med, 188, 2019, 10.1084/jem.188.11.2019 van Rijt, 2005, In vivo depletion of lung CD11c(+) dendritic cells during allergen challenge abrogates the characteristic features of asthma, J Exp Med, 201, 981, 10.1084/jem.20042311 Vermaelen, 2001, Specific migratory dendritic cells rapidly transport antigen from the airways to the thoracic lymph nodes, J Exp Med, 193, 51, 10.1084/jem.193.1.51 Cochand, 1999, Human lung dendritic cells have an immature phenotype with efficient mannose receptors, Am J Respir Cell Mol Biol, 21, 547, 10.1165/ajrcmb.21.5.3785 Belz, 2004, Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus, Proc Natl Acad Sci USA, 101, 8670, 10.1073/pnas.0402644101 Swanson, 2004, Flt3-ligand, IL-4, GM-CSF, and adherence-mediated isolation of murine lung dendritic cells: assessment of isolation technique on phenotype and function, J Immunol, 173, 4875, 10.4049/jimmunol.173.8.4875 Lambrecht, 1999, Allergen-induced changes in bone-marrow progenitor and airway dendritic cells in sensitized rats, Am J Respir Cell Mol Biol, 20, 1165, 10.1165/ajrcmb.20.6.3484 Julia, 2002, A restricted subset of dendritic cells captures airborne antigens and remains able to activate specific T cells long after antigen exposure, Immunity, 16, 271, 10.1016/S1074-7613(02)00276-5 Fainaru, 2004, Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammation, EMBO J, 23, 969, 10.1038/sj.emboj.7600085 Jahnsen, 2000, Experimentally induced recruitment of plasmacytoid (CD123high) dendritic cells in human nasal allergy, J Immunol, 165, 4062, 10.4049/jimmunol.165.7.4062 Demedts, 2004, Identification and characterisation of human pulmonary dendritic cells, Am J Respir Cell Mol Biol, 32, 177, 10.1165/rcmb.2004-0279OC Asselin-Paturel, 2003, Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody, J Immunol, 171, 6466, 10.4049/jimmunol.171.12.6466 Akbari, 2001, Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen, Nat Immunol, 2, 725, 10.1038/90667 Akbari, 2002, Antigen-specific regulatory T cells develop via the ICOS ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity, Nat Med, 29, 29 Lambrecht, 2000, Taking our breath away: dendritic cells in the pathogenesis of asthma, Nat Rev Immunol, 3, 994, 10.1038/nri1249 Banchereau, 1998, Dendritic cells and the control of immunity, Nature, 392, 245, 10.1038/32588 Brokaw, 1998, Glucocorticoid-induced apoptosis of dendritic cells in the rat tracheal mucosa, Am J Respir Cell Mol Biol, 19, 598, 10.1165/ajrcmb.19.4.2870 Hammad, 2003, Prostaglandin D2 inhibits airway dendritic cell migration and function in steady state conditions by selective activation of the D Prostanoid receptor 1, J Immunol, 171, 3936, 10.4049/jimmunol.171.8.3936 Hammad, 2004, Differential capacity of CD8+ alpha or CD8− alpha dendritic cell subsets to prime for eosinophilic airway inflammation in the T-helper type 2-prone milieu of the lung, Clin Exp Allergy, 34, 1834, 10.1111/j.1365-2222.2004.02133.x Smith, 1999, Antigen-pulsed CD8alpha+ dendritic cells generate an immune response after subcutaneous injection without homing to the draining lymph node, J Exp Med, 189, 593, 10.1084/jem.189.3.593 Steinman, 2002, Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance, Proc Natl Acad Sci USA, 99, 351, 10.1073/pnas.231606698 Wilson, 2004, Dendritic cells constitutively present self antigens in their immature state in vivo and regulate antigen presentation by controlling the rates of MHC class II synthesis and endocytosis, Blood, 103, 2187, 10.1182/blood-2003-08-2729 Bozza, 2002, Dendritic cells transport conidia and hyphae of Aspergillus fumigatus from the airways to the draining lymph nodes and initiate disparate Th responses to the fungus, J Immunol, 168, 1362, 10.4049/jimmunol.168.3.1362 Brimnes, 2003, Influenza virus-induced dendritic cell maturation is associated with the induction of strong T cell immunity to a coadministered, normally nonimmunogenic protein, J Exp Med, 198, 133, 10.1084/jem.20030266 Dahl, 2004, Viral-induced T helper type 1 responses enhance allergic disease by effects on lung dendritic cells, Nat Immunol, 5, 337, 10.1038/ni1041 Legge, 2003, Accelerated migration of respiratory dendritic cells to the regional lymph nodes is limited to the early phase of pulmonary infection, Immunity, 18, 265, 10.1016/S1074-7613(03)00023-2 Yamamoto, 2000, Dendritic cells are associated with augmentation of antigen sensitization by influenza A virus infection in mice, Eur J Immunol, 30, 316, 10.1002/1521-4141(200001)30:1<316::AID-IMMU316>3.0.CO;2-0 Eisenbarth, 2002, Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen, J Exp Med, 196, 1645, 10.1084/jem.20021340 Hogg, 2004, The nature of small-airway obstruction in chronic obstructive pulmonary disease, N Engl J Med, 350, 2645, 10.1056/NEJMoa032158 Sporri, 2005, Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper function, Nat Immunol, 6, 163, 10.1038/ni1162 Pasare, 2003, Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells, Science, 299, 1033, 10.1126/science.1078231 Rivino, 2004, Chemokine receptor expression identifies Pre-T helper (Th)1, Pre-Th2, and nonpolarized cells among human CD4+ central memory T cells, J Exp Med, 200, 725, 10.1084/jem.20040774 Kuipers, 2003, Lipopolysaccharide-induced suppression of airway Th2 responses does not require IL-12 production by dendritic cells, J Immunol, 171, 3645, 10.4049/jimmunol.171.7.3645 Kuipers, 2004, Dendritic cells retrovirally overexpressing IL-12 induce strong Th1 responses to inhaled antigen in the lung but fail to revert established Th2 sensitization, J Leuk Biol, 76, 1028, 10.1189/jlb.0604325 Ostroukhova, 2004, Tolerance induced by inhaled antigen involves CD4(+) T cells expressing membrane-bound TGF-beta and FOXP3, J Clin Invest, 114, 28, 10.1172/JCI200420509 Lambrecht, 2000, Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation, J Clin Invest, 106, 551, 10.1172/JCI8107 Hawiger, 2001, Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo, J Exp Med, 194, 769, 10.1084/jem.194.6.769 Jonuleit, 2001, Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood, J Exp Med, 193, 1285, 10.1084/jem.193.11.1285 Roncarolo, 2001, Differentiation of T regulatory cells by immature dendritic cells, J Exp Med, 193, F5, 10.1084/jem.193.2.F5 Gett, 2003, T cell fitness determined by signal strength, Nat Immunol, 4, 355, 10.1038/ni908 Tsitoura, 1999, Intranasal exposure to protein antigen induces immunological tolerance mediated by functionally disabled CD4+ T cells, J Immunol, 163, 2592, 10.4049/jimmunol.163.5.2592 Stock, 2004, Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity, Nat Immunol, 5, 1149, 10.1038/ni1122 Levings, 2001, IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells, J Immunol, 166, 5530, 10.4049/jimmunol.166.9.5530 Vieira, 2004, IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells, J Immunol, 172, 5986, 10.4049/jimmunol.172.10.5986 Higgins, 2003, Toll-like receptor 4-mediated innate IL-10 activates antigen-specific regulatory T cells and confers resistance to Bordetella pertussis by inhibiting inflammatory pathology, J Immunol, 171, 3119, 10.4049/jimmunol.171.6.3119 van Kooyk, 2003, DC-SIGN: escape mechanism for pathogens, Nat Rev Immunol, 3, 697, 10.1038/nri1182 Hammad, 2004, Activation of peroxisome proliferator-activated receptor-gamma in dendritic cells inhibits the development of eosinophilic airway inflammation in a mouse model of asthma, Am J Pathol, 164, 263, 10.1016/S0002-9440(10)63116-1 Moseman, 2004, Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells, J Immunol, 173, 4433, 10.4049/jimmunol.173.7.4433 Boonstra, 2003, Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential toll-like receptor ligation, J Exp Med, 197, 101, 10.1084/jem.20021908 Martin, 2002, Characterization of a new subpopulation of mouse CD8alpha+ B220+ dendritic cells endowed with type 1 interferon production capacity and tolerogenic potential, Blood, 100, 383, 10.1182/blood.V100.2.383 Fallarino, 2004, Murine plasmacytoid dendritic cells initiate the immunosuppressive pathway of tryptophan catabolism in response to CD200 receptor engagement, J Immunol, 173, 3748, 10.4049/jimmunol.173.6.3748 Hayashi, 2004, Inhibition of experimental asthma by indoleamine 2,3-dioxygenase, J Clin Invest, 114, 270, 10.1172/JCI21275 Cella, 2000, Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent TH1 polarization, Nat Immunol, 1, 305, 10.1038/79747 Dalod, 2003, Dendritic cell responses to early murine cytomegalovirus infection: subset functional specialization and differential regulation by interferon alpha/beta, J Exp Med, 197, 885, 10.1084/jem.20021522 Salio, 2004, CpG-matured murine plasmacytoid dendritic cells are capable of in vivo priming of functional CD8 T cell responses to endogenous but not exogenous antigens, J Exp Med, 199, 567, 10.1084/jem.20031059 Zuniga, 2004, Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection, Nat Immunol, 5, 1227, 10.1038/ni1136 Schwarze, 1997, Respiratory syncytial virus infection results in airway hyperresponsiveness and enhanced airway sensitization to allergen, J Clin Invest, 100, 226, 10.1172/JCI119516 van Rijt, 2002, Allergen-induced accumulation of airway dendritic cells is supported by an increase in CD31(hi)Ly-6C(neg) bone marrow precursors in a mouse model of asthma, Blood, 100, 3663, 10.1182/blood-2002-03-0673 van Rijt, 2004, Essential role of dendritic cell CD80/CD86 costimulation in the induction, but not reactivation, of TH2 effector responses in a mouse model of asthma, J Allergy Clin Immunol, 114, 166, 10.1016/j.jaci.2004.03.044 Hammad, 2000, Human dendritic cells in the severe combined immunodeficiency mouse model: their potentiating role in the allergic reaction, Lab Invest, 80, 605, 10.1038/labinvest.3780065 Salek-Ardakani, 2003, OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation, J Exp Med, 198, 315, 10.1084/jem.20021937 Oriss, 2005, Dynamics of dendritic cell phenotype and interactions with CD4+ T cells in airway inflammation and tolerance, J Immunol, 174, 854, 10.4049/jimmunol.174.2.854