Dementia, cognitive impairment and mortality in persons aged 65 and over living in the community: a systematic review of the literature
Tóm tắt
No recent attempt has been made to synthesise information on mortality and dementia despite the theoretical and practical interest in the topic. Our objective was to estimate the influence on mortality of cognitive impairment and dementia.
Data sources were Medline, Embase, personal files and colleagues' records. Studies were considered if they included a majority of persons aged 65 and over at baseline either drawn from a total community sample or drawn from a random sample from the community. Samples from health care facilities were excluded. The search located 68 community studies. Effect sizes were extracted from the studies and if they were not included in the published studies, effect sizes were calculated where possible: this was possible for 23 studies of cognitive impairment and 32 of dementia. No attempt was made to contact authors for missing data.
For the studies of cognitive impairment Fisher's method (a vote counting method), gave a
Levels of cognitive impairment commonly found in community studies give rise to an increased risk of mortality, and this appears to be true even for quite mild levels of impairment. The analysis confirms the increased risk of mortality for dementia, but reveals a dearth of information on the causes of the excess mortality and on possible effect modification by age, dementia subtype or other variables. Copyright © 2001 John Wiley & Sons, Ltd.
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Tài liệu tham khảo
Aronson MK, 1991, Dementia: age‐dependent incidence, prevalence and mortality in the old, Arch Intern Med, 151, 989, 10.1001/archinte.1991.00400050129024
Berr C, 1994, Cognitive performance and three‐year mortality in the PAQUID study, Revue d'Epidémiologie et de Santé Publique, 42, 277
Deeg DJH, 1990, The association between change in cognitive function and longevity in Dutch elderly, Am J Epidemiol, 132, 973, 10.1093/oxfordjournals.aje.a115740
Hill GB, 1997, Mortality and cognitive status among elderly Canadians living in the community and in institutions: the Canadian Study of Health and Aging, Can J Public Health, 88, 303, 10.1007/BF03403893
Ho SC, 1991, Health and social predictors of mortality in an elderly Chinese cohort, Am J Epidemiol, 133, 907, 10.1093/oxfordjournals.aje.a115970
Liu IY, 1990, Cognitive impairment and mortality: a study of possible confounders, Am J Epidemiol, 132, 136, 10.1093/oxfordjournals.aje.a115625
Magnússon H, 1989, Mental health of octogenarians in Iceland, Acta Psychiatr Scand, 79, 1
Petitti DB, 1994, Meta‐analysis, Decision Analysis, and Cost‐Effectiveness Analysis
Salive ME, 1993, Disability and cognitive impairment are risk factors for pneumonia‐related mortality in older adults, Public Health Rep, 108, 314
Schröppel H, 1994, Zur mortalität bei dementiellen and depressiven Erkrankungen im Alter, Zeitschrift für Gerontopsychologie und ‐psychiatrie, 7, 179
Smith P, 1987, Cancer Incidence in Five Continents Volume V, 790
Swan GE, 1995, Performance on the digit symbol substitution test and 5‐year mortality in the Western Collaborative Group Study, Am J Epidemiol, 141, 32, 10.1093/oxfordjournals.aje.a117342