Deletion of p22phox-dependent oxidative stress in the hypothalamus protects against obesity by modulating β3-adrenergic mechanisms

JCI insight - Tập 2 Số 2 - 2017
Heinrich E. Lob1, Jiunn Song1, Chansol Hurr2, Alvin Chung1, Colin N. Young1,2, Allyn L. Mark3,4, Robin L. Davisson1,3
1Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
2Department of Pharmacology and Physiology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA
3Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, New York, USA.
4Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

10.1016/S0092-8674(01)00240-9

10.1038/nn1455

10.1016/0006-8993(84)90443-8

10.1016/0006-8993(90)91129-5

10.1016/j.cmet.2013.01.006

10.1152/physrev.00015.2003

10.1002/j.1550-8528.1997.tb00591.x

Madden, 2009, Neurons in the paraventricular nucleus of the hypothalamus inhibit sympathetic outflow to brown adipose tissue, Am J Physiol Regul Integr Comp Physiol, 296, R831, 10.1152/ajpregu.91007.2008

10.1079/PNS19870017

10.1016/j.cmet.2014.07.005

10.1038/nature10777

10.1016/j.cell.2012.05.016

Bamshad, 1998, Central nervous system origins of the sympathetic nervous system outflow to white adipose tissue, Am J Physiol, 275, R291

10.1073/pnas.1002790107

10.1038/oby.2009.345

Harrison, 2003, Role of oxidative stress in atherosclerosis, Am J Cardiol, 91, 7A, 10.1016/S0002-9149(02)03144-2

10.1161/01.RES.86.5.494

10.1161/01.ATV.0000058402.34138.11

10.1089/ars.2010.3739

10.1210/en.2004-1520

10.1016/j.cell.2008.07.043

10.1111/j.1749-6632.2011.06388.x

10.1161/HYPERTENSIONAHA.111.00546

Laude, 2005, Hemodynamic and biochemical adaptations to vascular smooth muscle overexpression of p22phox in mice, Am J Physiol Heart Circ Physiol, 288, H7, 10.1152/ajpheart.00637.2004

10.1161/01.HYP.32.3.488

10.2337/db13-0719

10.1161/CIRCULATIONAHA.108.824730

10.1016/j.cmet.2008.12.014

10.1073/pnas.95.7.4061

10.1016/j.cmet.2011.06.020

10.1172/JCI44271

10.1016/j.cmet.2006.04.002

Vaughan, 1964, Hormone-sensitive lipase and monoglyceride lipase activities in adipose tissue, J Biol Chem, 239, 401, 10.1016/S0021-9258(18)51692-6

Bamshad, 1999, CNS origins of the sympathetic nervous system outflow to brown adipose tissue, Am J Physiol, 276, R1569

10.1016/j.cell.2014.03.066

10.1038/nm.2207

10.1161/CIRCRESAHA.111.243972

10.1161/01.RES.80.1.45

Oscai, 1984, Effect of dietary fat on food intake, growth and body composition in rats, Growth, 48, 415

Wilson, 1990, Identification of candidate genes for a factor regulating body weight in primates, Am J Physiol, 259, R1148

10.1210/jc.2012-3107

Veeneman, 2001, Re: Adey et al. Reduced synthesis of muscle proteins in chronic renal failure. Am J Physiol Endocrinol Metab. 278: E219-E225, 2000, Am J Physiol Endocrinol Metab, 280, E197, 10.1152/ajpendo.2001.280.1.E197

10.1161/CIRCRESAHA.109.213025

10.1161/01.CIR.0000128695.49900.12

10.1161/01.RES.0000135483.12297.e4

10.1016/j.pain.2013.07.024

10.1016/j.cmet.2014.12.009

Consoli, 2007, Behavioral effects of the beta3 adrenoceptor agonist SR58611A: is it the putative prototype of a new class of antidepressant/anxiolytic drugs?, Eur J Pharmacol, 573, 139, 10.1016/j.ejphar.2007.06.048

10.1161/HYPERTENSIONAHA.109.149286

10.1111/j.1476-5381.1995.tb17205.x

10.1073/pnas.84.20.7329

10.1016/0006-8993(85)91361-7

10.1016/j.biopsych.2012.01.017

10.1038/ijo.2010.34

10.1016/j.yfrne.2010.01.001

Tannenbaum, 1997, High-fat feeding alters both basal and stress-induced hypothalamic-pituitary-adrenal activity in the rat, Am J Physiol, 273, E1168

10.1210/en.2004-0037

10.1152/ajpendo.00448.2010

10.1523/JNEUROSCI.1632-05.2005

Tammariello, 2000, NADPH oxidase contributes directly to oxidative stress and apoptosis in nerve growth factor-deprived sympathetic neurons, J Neurosci, 20, 10.1523/JNEUROSCI.20-01-j0006.2000

10.1038/nm0596-545

10.1161/HYPERTENSIONAHA.110.160564

10.1152/physiolgenomics.00296.2007

10.1006/meth.2001.1262