Deletion of Crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2

Nature Genetics - Tập 24 Số 4 - Trang 415-419 - 2000
Toshimitsu Kishimoto1, Jelena Radulović2, Marko Radulović3, Chijen R. Lin4, Christina Schrick3, Farideh Hooshmand4, Ola Hermanson4, Michael G. Rosenfeld4, Joachim Spiess3
1Howard Hughes Medical Institute, Department and School of Medicine, University of California San Diego, La Jolla, CA, USA.
2Department for Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, Goettingen, Germany
3 Max Planck Institute of Experimental Medicine
4University of california at San Diego

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Spiess, J., Rivier, J., Rivier, C. & Vale, W. Primary structure of corticotropin-releasing factor from ovine hypothalamus. Proc. Natl Acad. Sci. USA 78, 6517–6521 (1981).

Vale, W., Spiess, J., Rivier, C. & Rivier, J. Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and β-endorphin. Science 213, 1394–1397 (1981).

Chang, C.P., Pearse, R.V., O'Connell, S. & Rosenfeld, M.G. Identification of a seven transmembrane helix receptor for corticotropin-releasing factor and sauvagine in mammalian brain. Neuron 11, 1187–1195 (1993).

Chen, R., Lewis, K.A., Perrin, M.H. & Vale, W.W. Expression cloning of a human corticotropin-releasing-factor receptor. Proc. Natl Acad. Sci. USA 90, 8967–8971 (1993).

Vita, N. et al. Primary structure and functional expression of mouse pituitary and human brain corticotrophin releasing factor receptors. FEBS Lett. 335, 1–5 (1993).

Kishimoto, T., Pearse, R.V., Lin, C.R. & Rosenfeld, M.G. A sauvagine/corticotropin-releasing factor receptor expressed in heart and skeletal muscle. Proc. Natl Acad. Sci. USA 92, 1108–1112 (1995).

Perrin, M. et al. Identification of a second corticotropin-releasing factor receptor gene and characterization of a cDNA expressed in heart. Proc. Natl Acad. Sci. USA 92, 2969–2973 (1995).

Lovenberg, T.W. et al. Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain. Proc. Natl Acad. Sci. USA 92, 836–840 (1995).

Stenzel, P. et al. Identification of a novel murine receptor for corticotropin-releasing hormone expressed in the heart. Mol. Endocrinol. 9, 637–645 (1995).

Rossant, C.J., Pinnock, R.D., Hughes, J., Hall, M.D. & McNulty, S. Corticotropin-releasing factor type 1 and type 2α receptors regulate phosphorylation of calcium/cyclic adenosine 3′,5′-monophosphate response element-binding protein and activation of p42/p44 mitogen-activated protein kinase. Endocrinology 140, 1525–1536 (1999).

Timpl, P. et al. Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. Nature Genet. 19, 162–166 (1998).

Smith, G.W. et al. Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development. Neuron 20, 1093–1102 (1998).

Chalmers, D.T., Lovenberg, T.W. & De Souza, E.B. Localization of novel corticotropin-releasing factor receptor (CRF2) mRNA expression to specific subcortical nuclei in rat brain: comparison with CRF1 receptor mRNA expression. J. Neurosci. 15, 6340–6350 (1995).

Lee, E.H.Y. & Tsai, M.J. The hippocampus and amygdala mediate the locomotor stimulating effects of corticotropin-releasing factor in mice. Behav. Neural Biol. 51, 412–423 (1989).

Rühmann, A., Bonk, I., Lin, C.R., Rosenfeld, M.G. & Spiess, J. Structural requirements for peptidic antagonists of the corticotropin-releasing factor receptor (CRFR): development of CRFR2β-selective antisauvagine-30. Proc. Natl Acad. Sci. USA 95, 15264–15269 (1998).

Stenzel-Poore, M.P., Heinrichs, S.C., Rivest, S., Koob, G.F. & Vale, W.W. Overproduction of corticotropin-releasing factor in transgenic mice: a genetic model of anxiogenic behavior. J. Neurosci. 14, 2579–2584 (1994).

Baldwin, H.A., Rassnick, S., Rivier, J., Koob, G.F. & Britton, K.T. CRF antagonist reverses the ‘anxiogenic’ response to ethanol withdrawal in the rat. Psychopharmacology 103, 227–232 (1991).

Carey, M.P., Billing, A.E. & Fry, J.P. Fluctuations in responses to diazepam during the oestrus cycle in the mouse. Pharmacol. Biochem. Behav. 41, 719–725 (1992).

Hinks, G.L., Brown, P., Field, M., Poat, J.A. & Hughes, J. The anxiolytics CI-988 and chlordiazepoxide fail to reduce immediate early gene mRNA stimulation following exposure to the rat elevated X-maze. Eur. J. Pharmacol. 312, 153–161 (1996).

Radulovic, J., Kammermeier, J. & Spiess, J. Relationship between FOS production and classical fear conditioning: effects of novelty, latent inhibition and unconditioned stimulus preexposure. J. Neurosci. 18, 7452–7461 (1998).

Fisher, L.A. Corticotropin-releasing factor: endocrine and autonomic integration of responses to stress. Trends Pharmacol. Sci. 10, 189–193 (1989).

Turnbull, A.V., Vale, W. & Rivier, C. Urocortin, a corticotropin-releasing factor-related mammalian peptide, inhibits edema due to thermal injury in rats. Eur. J. Pharmacol. 303, 213–216 (1996).

Fox, W.M. Reflex-ontogeny and behavioural development of the mouse. Animal Behav. 13, 234–264 (1965).

Allen, E. The oestrus cycle in the mouse. Am. J. Anat. 30, 297–371, 1922.

Lister, R.G. The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology 92, 180–185 (1987).

Rodgers, R.J. & Johnson, N.J. Factor analysis of spatiotemporal and ethological measures in the murine elevated plus-maze test of anxiety. Pharmacol. Biochem. Behav. 52, 297–303 (1995).

Takahashi, L.K., Kalin, N.H., Vanden Burgt, J.A. & Sherman, J.E. Corticotropin-releasing factor modulates defensive-withrawal and exploratory behavior in rats. Behav. Neurosci. 103, 645–654.

Radulovic, J., Rühmann, A., Liepold, T. & Spiess, J. Modulation of learning and anxiety by corticotropin-releasing factor (CRF) and stress: differential roles of CRF receptors 1 and 2. J. Neurosci. 15, 5016–5025 (1999).

Wei, E.T. & Thomas, H.A. Correlation of neuroendocrine and anti-edema activities of alanine-corticotropin-releasing factor analogs. Eur. J. Pharmacol. 263, 319–321 (1994).