Delayed administration of the human anti-RGMa monoclonal antibody elezanumab promotes functional recovery including spontaneous voiding after spinal cord injury in rats

Anderson, 2004, Targeting recovery: priorities of the spinal cord-injured population, J. Neurotrauma, 21, 1371, 10.1089/neu.2004.21.1371 Arnold, 2011, Spinal cord compression secondary to intrathecal catheter-induced granuloma: a report of four cases, Evid. Based Spine Care J., 2, 57, 10.1055/s-0030-1267087 Bartus, 2012, Chondroitin sulphate proteoglycans: key modulators of spinal cord and brain plasticity, Exp. Neurol., 235, 5, 10.1016/j.expneurol.2011.08.008 Basso, 1995, A sensitive and reliable locomotor rating scale for open field testing in rats, J. Neurotrauma, 12, 1, 10.1089/neu.1995.12.1 Bradbury, 2002, Chondroitinase ABC promotes functional recovery after spinal cord injury, Nature, 416, 636, 10.1038/416636a Bregman, 1995, Recovery from spinal cord injury mediated by antibodies to neurite growth inhibitors, Nature, 378, 498, 10.1038/378498a0 Bruce, 2002, Chronic pain after clip-compression injury of the rat spinal cord, Exp. Neurol., 178, 33, 10.1006/exnr.2002.8026 Chen, 2019, Inhibition of neogenin promotes neuronal survival and improved behavior recovery after spinal cord injury, Neuroscience, 408, 430, 10.1016/j.neuroscience.2019.03.055 Chio, 2019, The effects of human immunoglobulin G on enhancing tissue protection and neurobehavioral recovery after traumatic cervical spinal cord injury are mediated through the neurovascular unit, J. Neuroinflammation, 16, 10.1186/s12974-019-1518-0 De Girolami, 2002, Diseases of the spinal cord and vertebral column, 1063 Demicheva, 2015, Targeting repulsive guidance molecule A to promote regeneration and neuroprotection in multiple sclerosis, Cell Rep., 10, 1887, 10.1016/j.celrep.2015.02.048 Dubreuil, 2003, Rho activation patterns after spinal cord injury and the role of activated Rho in apoptosis in the central nervous system, J. Cell Biol., 162, 233, 10.1083/jcb.200301080 Fry, 2010, Corticospinal tract regeneration after spinal cord injury in receptor protein tyrosine phosphatase sigma deficient mice, Glia, 58, 423 Hama, 2011, Antinociceptive effect of riluzole in rats with neuropathic spinal cord injury pain, J. Neurotrauma, 28, 127, 10.1089/neu.2010.1539 Hamers, 2001, Automated quantitative gait analysis during overground locomotion in the rat: its application to spinal cord contusion and transection injuries, J. Neurotrauma, 18, 187, 10.1089/08977150150502613 Hata, 2006, RGMa inhibition promotes axonal growth and recovery after spinal cord injury, J. Cell Biol., 173, 47, 10.1083/jcb.200508143 Kwon, 2010, Cerebrospinal fluid inflammatory cytokines and biomarkers of injury severity in acute human spinal cord injury, J. Neurotrauma, 27, 669, 10.1089/neu.2009.1080 Kyoto, 2007, Synapse formation of the cortico-spinal axons is enhanced by RGMa inhibition after spinal cord injury, Brain Res., 1186, 74, 10.1016/j.brainres.2007.10.038 Lah, 2012, Dual roles of the chemorepellent axon guidance molecule RGMa in establishing pioneering axon tracts and neural fate decisions in embryonic vertebrate forebrain, Dev. Neurobiol., 72, 1458, 10.1002/dneu.22010 Lankhorst, 1999, Functional recovery after central infusion of alpha-melanocyte-stimulating hormone in rats with spinal cord contusion injury, J. Neurotrauma, 16, 323, 10.1089/neu.1999.16.323 Li, 2004, Blockade of Nogo-66, myelin-associated glycoprotein, and oligodendrocyte myelin glycoprotein by soluble Nogo-66 receptor promotes axonal sprouting and recovery after spinal injury, J. Neurosci., 24, 10511, 10.1523/JNEUROSCI.2828-04.2004 Matsunaga, 2004, RGM and its receptor neogenin regulate neuronal survival, Nat. Cell Biol., 6, 749, 10.1038/ncb1157 Matsunaga, 2006, Repulsive guidance molecule plays multiple roles in neuronal differentiation and axon guidance, J. Neurosci., 26, 6082, 10.1523/JNEUROSCI.4556-05.2006 McKerracher, 1994, Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth, Neuron, 13, 805, 10.1016/0896-6273(94)90247-X Metz, 2002, Cortical and subcortical lesions impair skilled walking in the ladder rung walking test: a new task to evaluate fore- and hindlimb stepping, placing, and co-ordination, J. Neurosci. Methods, 115, 169, 10.1016/S0165-0270(02)00012-2 Monnier, 2002, RGM is a repulsive guidance molecule for retinal axons, Nature, 419, 392, 10.1038/nature01041 Mothe, 2011, Intrathecal transplantation of stem cells by lumbar puncture for thoracic spinal cord injury in the rat, Spinal Cord, 49, 967, 10.1038/sc.2011.46 Mothe, 2017, RGMa inhibition with human monoclonal antibodies promotes regeneration, plasticity and repair, and attenuates neuropathic pain after spinal cord injury, Sci. Rep., 7, 10.1038/s41598-017-10987-7 Muramatsu, 2011, RGMa modulates T cell responses and is involved in autoimmune encephalomyelitis, Nat. Med., 17, 488, 10.1038/nm.2321 Nakagawa, 2019, Treatment with the neutralizing antibody against repulsive guidance molecule-a promotes recovery from impaired manual dexterity in a primate model of spinal cord injury, Cereb. Cortex, 29, 561, 10.1093/cercor/bhx338 Niederkofler, 2004, Repulsive guidance molecule (RGM) gene function is required for neural tube closure but not retinal topography in the mouse visual system, J. Neurosci., 24, 808, 10.1523/JNEUROSCI.4610-03.2004 O’Leary, 2013, RGMa regulates cortical interneuron migration and differentiation, PLoS One, 8 Peng, 2004, Spinal cord compression from intrathecal catheter-tip inflammatory mass: case report and a review of etiology, Reg. Anesth. Pain Med., 29, 237 Rajagopalan, 2004, Neogenin mediates the action of repulsive guidance molecule, Nat. Cell Biol., 6, 756, 10.1038/ncb1156 Rivlin, 1978, Effect of duration of acute spinal cord compression in a new acute cord injury model in the rat, Surg. Neurol., 10, 38 Satoh, 2013, Accumulation of a repulsive axonal guidance molecule RGMa in amyloid plaques: a possible hallmark of regenerative failure in Alzheimer’s disease brains, Neuropathol. Appl. Neurobiol., 39, 109, 10.1111/j.1365-2990.2012.01281.x Schneider, 2019, Anti-Nogo-A antibodies as a potential causal therapy for lower urinary tract dysfunction after spinal cord injury, J. Neurosci., 39, 4066, 10.1523/JNEUROSCI.3155-18.2019 Schnell, 1990, Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors, Nature, 343, 269, 10.1038/343269a0 Schwab, 2005, Spinal cord injury-induced lesional expression of the repulsive guidance molecule (RGM), Eur. J. Neurosci., 21, 1569, 10.1111/j.1460-9568.2005.03962.x Shabanzadeh, 2015, Uncoupling Neogenin association with lipid rafts promotes neuronal survival and functional recovery after stroke, Cell Death Dis., 6, e1744, 10.1038/cddis.2015.109 Shifman, 2009, Expression of the repulsive guidance molecule RGM and its receptor neogenin after spinal cord injury in sea lamprey, Exp. Neurol., 217, 242, 10.1016/j.expneurol.2009.02.011 Shunmugavel, 2015, S-Nitrosoglutathione protects the spinal bladder: novel therapeutic approach to post-spinal cord injury bladder remodeling, Neurourol. Urodyn., 34, 519, 10.1002/nau.22619 Stammers, 2012, Expression of inflammatory cytokines following acute spinal cord injury in a rodent model, J. Neurosci. Res., 90, 782, 10.1002/jnr.22820 Tanabe, 2018, Inhibiting repulsive guidance molecule-a suppresses secondary progression in mouse models of multiple sclerosis, Cell Death Dis., 9, 10.1038/s41419-018-1118-4 Tassew, 2012, SKI-1 and Furin generate multiple RGMa fragments that regulate axonal growth, Dev. Cell, 22, 391, 10.1016/j.devcel.2011.11.022 Tassew, 2014, Modifying lipid rafts promotes regeneration and functional recovery, Cell Rep., 8, 1146, 10.1016/j.celrep.2014.06.014 Tator, 1991, Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms, J. Neurosurg., 75, 15, 10.3171/jns.1991.75.1.0015 Tian, 2013, Repulsive guidance molecules (RGMs) and neogenin in bone morphogenetic protein (BMP) signaling, Mol. Reprod. Dev., 80, 700, 10.1002/mrd.22199 Wang, 2002, P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp, Nature, 420, 74, 10.1038/nature01176 Wu, 2013, Delayed post-injury administration of riluzole is neuroprotective in a preclinical rodent model of cervical spinal cord injury, J. Neurotrauma, 30, 441, 10.1089/neu.2012.2622 Zhang, 2018, RGMa mediates reactive astrogliosis and glial scar formation through TGFbeta1/Smad2/3 signaling after stroke, Cell Death Differ., 25, 1503, 10.1038/s41418-018-0058-y