Dehydroepiandrosterone: a potential therapeutic agent in the treatment and rehabilitation of the traumatically injured patient

Hastings, 2014, The metabolic and endocrine response to trauma, Anaesth Intensive Care, 15, 432, 10.1016/j.mpaic.2014.06.012

Lord, 2014, The systemic immune response to trauma: an overview of pathophysiology and treatment, Lancet, 384, 1455, 10.1016/S0140-6736(14)60687-5

Krepska, 2017, The metabolic and endocrine response to trauma, Anaesth Intensive Care, 18, 414, 10.1016/j.mpaic.2017.05.007

Haider, 2009, Females have fewer complications and lower mortality following trauma than similarly injured males: a risk adjusted analysis of adults in the National Trauma Data Bank, Surgery, 146, 308, 10.1016/j.surg.2009.05.006

Gannon, 2004, Male gender is associated with increased risk for postinjury pneumonia, Shock, 21, 410, 10.1097/00024382-200405000-00003

Braun, 2016, Polytrauma in the elderly: a review, EFORT Open Rev, 1, 146, 10.1302/2058-5241.1.160002

Al-Tarrah, 2017, The influence of sex steroid hormones on the response to trauma and burn injury, Burns Trauma BioMed Central, 5, 29, 10.1186/s41038-017-0093-9

Roger, 2005, Macrophage migration inhibitory factor promotes innate immune responses by suppressing glucocorticoid-induced expression of mitogen-activated protein kinase phosphatase-1, Eur J Immunol, 35, 3405, 10.1002/eji.200535413

Ronchetti, 2018, How Glucocorticoids Affect the Neutrophil Life, International Journal of Molecular Sciences, 19, 4090, 10.3390/ijms19124090

Sorrells, 2007, An inflammatory review of glucocorticoid actions in the CNS, Brain Behav Immun, 21, 259, 10.1016/j.bbi.2006.11.006

Ilias, 2007, Contribution of endocrine parameters in predicting outcome of multiple trauma patients in an intensive care unit, Hormones, 6, 218

Arlt, 2006, Dissociation of serum dehydroepiandrosterone and dehydroepiandrosterone sulfate in septic shock, J Clin Endocrinol Metab, 91, 2548, 10.1210/jc.2005-2258

Pugin, 2012, How tissue injury alarms the immune system and causes a systemic inflammatory response syndrome, Ann Intensive Care, 2, 27, 10.1186/2110-5820-2-27

Manson, 2012, Trauma alarmins as activators of damage-induced inflammation, Br J Surg, 99, 12, 10.1002/bjs.7717

Scaffidi, 2002, Release of chromatin protein HMGB1 by necrotic cells triggers inflammation, Nature, 418, 191, 10.1038/nature00858

Zhang, 2010, Circulating mitochondrial DAMPs cause inflammatory responses to injury, Nature, 464, 104, 10.1038/nature08780

Kaczmarek, 2018, A subset of five human mitochondrial formyl peptides mimics bacterial peptides and functionally deactivates human neutrophils, J Trauma Acute Care, 85, 936, 10.1097/TA.0000000000001971

Burk, 2012, Early complementopathy after multiple injuries in humans, Shock, 37, 348, 10.1097/SHK.0b013e3182471795

Ward, 2008, The Compensatory Anti-inflammatory Response Syndrome (CARS) in critically ill patients, Clin Chest Med, 29, 617, 10.1016/j.ccm.2008.06.010

Appleton, 2015, The incidence of intensive care unit-acquired weakness syndromes: a systematic review, J Intensive Care Soc, 16, 126, 10.1177/1751143714563016

Mira, 2017, Persistent inflammation, immunosuppression and catabolism syndrome, Crit Care Clin, 33, 245, 10.1016/j.ccc.2016.12.001

Hodgson, 2017, Physiotherapy management of intensive care unit-acquired weakness, Aust J Phys, 63, 4

Puthucheary, 2013, Acute skeletal muscle wasting in critical illness, JAMA, 310, 1591, 10.1001/jama.2013.278481

Wafaisade, 2011, Epidemiology and risk factors of sepsis after multiple trauma: an analysis of 29,829 patients from the trauma registry of the German Society for Trauma Surgery, Crit Care Med, 39, 621, 10.1097/CCM.0b013e318206d3df

Liu, 2015, The influence of sex on outcomes in trauma patients: a meta-analysis, Am J Surg, 210, 911, 10.1016/j.amjsurg.2015.03.021

Verma, 2017, Gender-based assessment of survival in trauma-hemorrhagic shock:a retrospective analysis of Indian population, Indian J Crit Care Med, 21, 218, 10.4103/ijccm.IJCCM_304_16

Hicks, 2014, Association between race and age in survival after trauma, JAMA Surg, 149, 642, 10.1001/jamasurg.2014.166

Rainey, 2002, Dissecting human adrenal androgen production, Trends Endocrinol Metab, 13, 234, 10.1016/S1043-2760(02)00609-4

Orentreich, 1992, Long-term longitudinal measurements of plasma dehydroepiandrosterone sulfate in normal men, J Clin Endocrinol Metab, 75, 1002

Saltzman, 2006, Dehydroepiandrosterone therapy as female androgen replacement, Semin Reprod Med, 24, 97, 10.1055/s-2006-939568

Rege, 2012, The steroid metabolome of adrenarche, J Endocrinol, 214, 133, 10.1530/JOE-12-0183

Labrie, 1997, Effect of 12-month dehydroepiandrosterone replacement therapy on bone, vagina, and endometrium in postmenopausal women, J Clin Endocrinol Metab, 82, 3498, 10.1210/jcem.82.10.4306

Kiechl, 2000, No association between dehydroepiandrosterone sulfate and development of atherosclerosis in a prospective population study (Bruneck Study), Arterioscler Thromb Vasc Biol, 20, 1094, 10.1161/01.ATV.20.4.1094

Jarrar, 2001, DHEA: a novel adjunct for the treatment of male trauma patients, Trends Mol Med, 7, 81, 10.1016/S1471-4914(01)01917-7

Rainey, 2008, Regulation of the adrenal androgen biosynthesis, J Steroid Biochem Mol Biol, 108, 281, 10.1016/j.jsbmb.2007.09.015

Krug, 2008, DHEA and DHEA-S, and their functions in the brain and adrenal medulla, Neuroactive steroids in brain function, behavior and neuropsychiatric disorders, 229, 10.1007/978-1-4020-6854-6_12

Ghosh, 2007, Human sulfatases: a structural perspective to catalysis, Cell Mol Life Sci, 64, 2013, 10.1007/s00018-007-7175-y

Mueller, 2015, The regulation of steroid action by sulfation and desulfation, Endocr Rev, 36, 526, 10.1210/er.2015-1036

Prough, 2016, Novel mechanisms for DHEA action, J Mol Endocrinol, 56, R139, 10.1530/JME-16-0013

Svec, 1998, The actions of exogenous dehydroepiandrosterone in experimental animals and humans, Proc Soc Exp Biol Med, 218, 174, 10.3181/00379727-218-44285

Hazeldine, 2010, Dehydroepiandrosterone as a regulator of immune cell function, J Steroid Biochem Mol Biol, 120, 127, 10.1016/j.jsbmb.2009.12.016

Radford, 2010, Dehydroepiandrosterone sulfate directly activates protein kinase C-beta to increase human neutrophil superoxide generation, Mol Endocrinol, 24, 813, 10.1210/me.2009-0390

Bancos, 2017, Primary adrenal insufficiency is associated with impaired natural killer cell function: a potential link to increased mortality, Eur J Endocrinol, 176, 471, 10.1530/EJE-16-0969

Smans, 2013, Increased use of antimicrobial agents and hospital admission for infections in patients with primary adrenal insufficiency: a cohort study, Eur J Endocrinol, 168, 609, 10.1530/EJE-12-0879

Edvardsen, 2015, Peripheral Blood Cells from Patients with Autoimmune Addison's Disease Poorly Respond to Interferons In Vitro, Despite Elevated Serum Levels of Interferon-Inducible Chemokines, Journal of Interferon & Cytokine Research, 35, 759, 10.1089/jir.2014.0171

Parker, 1985, Evidence for adrenocortical adaptation to severe illness, J Clin Endocrinol Metab, 60, 947, 10.1210/jcem-60-5-947

Phillips, 2010, Cortisol, DHEA sulphate, their ratio, and all-cause and cause-specific mortality in the Vietnam Experience Study, Eur J Endocrinol, 163, 285, 10.1530/EJE-10-0299

Carroll, 2011, Cortisol, dehydroepiandrosterone sulphate, their ratio and hypertension: evidence of associations in male veterans from the Vietnam Experience Study, J Hum Hypertens, 25, 418, 10.1038/jhh.2011.6

Phillips, 2013, Depression following hip fracture is associated with increased physical frailty in older adults: the role of the cortisol: dehydroepiandrosterone sulphate ratio, BMC Geriatr BioMed Central, 13, 60, 10.1186/1471-2318-13-60

Duggal, 2013, Depressive symptoms are associated with reduced neutrophil function in hip fracture patients, Brain Behav Immun, 33, 173, 10.1016/j.bbi.2013.07.004

Duggal, 2014, Depressive symptoms in hip fracture patients are associated with reduced monocyte superoxide production, Exp Gerontol, 54, 27, 10.1016/j.exger.2014.01.028

Maninger, 2009, Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS), Front Neuroendocrinol, 30, 65, 10.1016/j.yfrne.2008.11.002

Mocking, 2015, DHEAS and cortisol/DHEAS-ratio in recurrent depression: state, or trait predicting 10-year recurrence?, Psychoneuroendocrinology, 59, 91, 10.1016/j.psyneuen.2015.05.006

Kolditz, 2010, Adrenal function is related to prognosis in moderate community-acquired pneumonia, Eur Respir J, 36, 615, 10.1183/09031936.00191709

Sharshar, 2010, Hormonal status and ICU-acquired paresis in critically ill patients, Intensive Care Med, 36, 1318, 10.1007/s00134-010-1840-6

Sharshar, 2011, Hormonal status in protracted critical illness and in-hospital mortality, Crit Care BioMed Central, 15, R47, 10.1186/cc10010

Klouche, 2007, Hypothalamic-pituitary-adrenal axis reactivity and dehydroepiandrosterone sulfate plasma concentrations in the critically ill elderly, Age Ageing, 36, 686, 10.1093/ageing/afm113

Chinga-Alayo, 2005, Thyroid hormone levels improve the prediction of mortality among patients admitted to the intensive care unit, Intensive Care Med, 31, 1356, 10.1007/s00134-005-2719-9

Dimopoulou, 2007, A prospective study on adrenal cortex responses and outcome prediction in acute critical illness: results from a large cohort of 203 mixed ICU patients, Intensive Care Med, 33, 2116, 10.1007/s00134-007-0790-0

Beishuizen, 2002, Decreased levels of dehydroepiandrosterone sulphate in severe critical illness: a sign of exhausted adrenal reserve?, Crit Care, 6, 434, 10.1186/cc1530

Van den Berghe, 2002, The combined administration of GH-releasing peptide-2 (GHRP-2), TRH and GnRH to men with prolonged critical illness evokes superior endocrine and metabolic effects compared to treatment with GHRP-2 alone, Clin Endocrinol, 56, 655, 10.1046/j.1365-2265.2002.01255.x

Spratt, 1993, Differential changes in serum concentrations of androgens and estrogens (in relation with cortisol) in postmenopausal women with acute illness, J Clin Endocrinol Metab, 76, 1542

Gottschlich, 2009, An evaluation of the neuroendocrine response to sleep in pediatric burn patients, JPEN-Parenter Enter, 33, 317, 10.1177/0148607108325180

Van Den Berghe, 1995, Dehydroepiandrosterone-sulfate in critical illness - effect of dopamine, Clin Endocrinol, 43, 457, 10.1111/j.1365-2265.1995.tb02618.x

Osorio, 2002, Dehydroepiandrosterone sulfate and growth axis hormones in patients after surgery, World J Surg, 26, 1079, 10.1007/s00268-002-6368-7

Almoosa, 2014, Low testosterone levels are frequent in patients with acute respiratory failure and are associated with poor outcomes, Endocr Pract, 20, 1057, 10.4158/EP14003.OR

Dolecek, 2003, Endocrine changes after burns: the bone involvement, Acta Chir Plast, 45, 95

Dossett, 2008, High levels of endogenous estrogens are associated with death in the critically injured adult, J Trauma, 64, 580, 10.1097/TA.0b013e31816543dd

Folan, 2001, Dehydroepiandrosterone, dehydroepiandrosterone-sulfate, and cortisol concentrations in intensive care unit patients, Crit Care Med, 29, 965, 10.1097/00003246-200105000-00012

Brorsson, 2014, Adrenal response after trauma is affected by time after trauma and sedative/analgesic drugs, Injury, 45, 1149, 10.1016/j.injury.2014.02.001

Mueller, 2014, Association of Adrenal Function and Disease Severity in Community-Acquired Pneumonia, PLoS ONE, 9, e99518, 10.1371/journal.pone.0099518

Taylor, 2015, Mass spectrometry and immunoassay: how to measure steroid hormones today and tomorrow, Eur J Endocrinol, 173, D1, 10.1530/EJE-15-0338

Butcher, 2005, Raised cortisol: DHEAS ratios in the elderly after injury: potential impact upon neutrophil function and immunity, Aging Cell, 4, 319, 10.1111/j.1474-9726.2005.00178.x

Sato, 2011, Increased muscular dehydroepiandrosterone levels are associated with improved hyperglycemia in obese rats, Am J Physiol Endocrinol Metab, 301, E274, 10.1152/ajpendo.00564.2010

Angele, 1998, Dehydroepiandrosterone: an inexpensive steroid hormone that decreases the mortality due to sepsis following trauma-induced hemorrhage, Arch Surg, 133, 1281, 10.1001/archsurg.133.12.1281

Karishma, 2002, Dehydroepiandrosterone (DHEA) stimulates neurogenesis in the hippocampus of the rat, promotes survival of newly formed neurons and prevents corticosterone-induced suppression, Eur J Neurosci, 16, 445, 10.1046/j.1460-9568.2002.02099.x

Lohman, 1997, Dehydroepiandrosterone protects muscle flap microcirculatory hemodynamics from ischemia/reperfusion injury: an experimental in vivo study, J Trauma, 42, 74, 10.1097/00005373-199701000-00013

Punjabi, 1983, Androgen and precursor levels in serum and testes of adult rats under basal conditions and after hCG stimulation, J Steroid Biochem, 19, 1481, 10.1016/0022-4731(83)91124-X

Zhou, 2015, Ample Evidence: Dehydroepiandrosterone (DHEA) Conversion into Activated Steroid Hormones Occurs in Adrenal and Ovary in Female Rat, PLOS ONE, 10, e0124511, 10.1371/journal.pone.0124511

Kobbe, 2013, Increased morbidity and mortality after bilateral femoral shaft fractures: Myth or reality in the era of damage control?, Injury, 44, 221, 10.1016/j.injury.2012.09.011

Knoferl, 2003, Immunomodulatory effects of dehydroepiandrosterone in proestrus female mice after trauma-hemorrhage, JAP, 95, 529

Catania, 1999, Dehydroepiandrosterone restores immune function following trauma-haemorrhage by a direct effect on T lymphocytes, Cytokine, 11, 443, 10.1006/cyto.1998.0458

Oberbeck, 2007, Dehydroepiandrosterone: a modulator of cellular immunity and heat shock protein 70 production during polymicrobial sepsis, Intensive Care Med, 33, 2207, 10.1007/s00134-007-0851-4

Araneo, 1993, Administration of dehydroepiandrosterone to burned mice preserves normal immunologic competence, Arch Surg., 128, 318, 10.1001/archsurg.1993.01420150074014

Araneo, 1995, Dehydroepiandrosterone reduces progressive dermal ischemia caused by thermal injury, J Surg Res, 59, 250, 10.1006/jsre.1995.1162

Hampson, 2017, Neutrophil dysfunction, immature granulocytes, and cell-free dna are early biomarkers of sepsis in burn-injured patients: a prospective observational cohort study, Ann Surg, 265, 1241, 10.1097/SLA.0000000000001807

Perner, 2003, High glucose impairs superoxide production from isolated blood neutrophils, Intensive Care Med, 29, 642, 10.1007/s00134-002-1628-4

Corsini, 2016, Role of androgens in dhea-induced rack1 expression and cytokine modulation in monocytes, Immun Ageing, 13, 20, 10.1186/s12979-016-0075-y

Curatola, 2012, Dehydroepiandrosterone (DHEA) Inhibition of Monocyte Binding by Vascular Endothelium Is Associated With Sialylation of Neural Cell Adhesion Molecule, Reproductive Sciences, 19, 86, 10.1177/1933719111414210

Schmidt, 2000, Conversion of dehydroepiandrosterone to downstream steroid hormones in macrophages, J Endocrinol, 164, 161, 10.1677/joe.0.1640161

Li, 2007, Pathophysiology of acute wound healing, Clin Dermatol, 25, 9, 10.1016/j.clindermatol.2006.09.007

Reinke, 2012, Wound Repair and Regeneration, European Surgical Research, 49, 35, 10.1159/000339613

Ayhan, 2003, Dehydroepiandrosterone protects the microcirculation of muscle flaps from ischemia-reperfusion injury by reducing the expression of adhesion molecules, Plast Reconstr Surg, 111, 2286, 10.1097/01.PRS.0000060242.85268.8F

Shin, 2005, Modulation of collagen metabolism by the topical application of dehydroepiandrosterone to human skin, J Invest Dermatol, 124, 315, 10.1111/j.0022-202X.2004.23588.x

Padgett, 1998, Endocrine regulation of murine macrophage function: effects of dehydroepiandrosterone, androstenediol, and androstenetriol, Journal of Neuroimmunology, 84, 61, 10.1016/S0165-5728(97)00244-0

Cutolo, 2005, Sex hormone modulation of cell growth and apoptosis of the human monocytic/macrophage cell line, Arthritis Res Ther, 7, R1124, 10.1186/ar1791

Corcoran, 2010, Sex hormone modulation of proinflammatory cytokine and C-reactive protein expression in macrophages from older men and postmenopausal women, J Endocrinol, 206, 217, 10.1677/JOE-10-0057

Mills, 2005, The sex steroid precursor DHEA accelerates cutaneous wound healing via the estrogen receptors, J Invest Dermatol, 125, 1053, 10.1111/j.0022-202X.2005.23926.x

Stoffel-Wagner, 2001, Neurosteroid metabolism in the human brain, Eur J Endocrinol, 145, 669, 10.1530/eje.0.1450669

Dong, 2011, Dehydroepiandrosterone sulphate: action and mechanism in the brain, J Neuroendocrinol, 24, 215, 10.1111/j.1365-2826.2011.02256.x

Malik, 2003, A novel dehydroepiandrosterone analog improves functional recovery in a rat traumatic brain injury model, J Neurotrauma, 20, 463, 10.1089/089771503765355531

Hoffman, 2003, The delayed administration of dehydroepiandrosterone sulfate improves recovery of function after traumatic brain injury in rats, J Neurotrauma Inc, 20, 859, 10.1089/089771503322385791

Suzuki, 2004, Mitotic and neurogenic effects of dehydroepiandrosterone (DHEA) on human neural stem cell cultures derived from the fetal cortex, Proc Natl Acad Sci, 101, 3202, 10.1073/pnas.0307325101

Rahmani, 2013, Dehydroepiandrosterone Stimulates Nerve Growth Factor and Brain Derived Neurotrophic Factor in Cortical Neurons, Advances in Pharmacological Sciences, 2013, 1, 10.1155/2013/506191

Kibaly, 2008, Biochemical and functional evidence for the control of pain mechanisms by dehydroepiandrosterone endogenously synthesized in the spinal cord, FASEB J, 22, 93, 10.1096/fj.07-8930com

de Vries, 2009, The lifetime prevalence of traumatic events and posttraumatic stress disorder in the Netherlands, J Trauma Stress, 22, 259, 10.1002/jts.20429

O'Donnell, 2005, Determinants of quality of life and role-related disability after injury: impact of acute psychological responses, J Trauma, 59, 1328, 10.1097/01.ta.0000197621.94561.4e

Salyers, 2004, Barriers to assessment and treatment of posttraumatic stress disorder and other trauma-related problems in people with severe mental illness: clinician perspectives, Community Ment Health J, 40, 17, 10.1023/B:COMH.0000015215.45696.5f

Pitman, 2012, Biological studies of post-traumatic stress disorder, Nat Rev Neurosci, 13, 769, 10.1038/nrn3339

Michael, 2000, Altered salivary dehydroepiandrosterone levels in major depression in adults, Biol Psychiatry, 48, 989, 10.1016/S0006-3223(00)00955-0

Souza-Teodoro, 2016, Higher serum dehydroepiandrosterone sulfate protects against the onset of depression in the elderly: findings from the English Longitudinal Study of Aging (ELSA), Psychoneuroendocrinology, 64, 40, 10.1016/j.psyneuen.2015.11.005

Schmidt, 2005, Dehydroepiandrosterone monotherapy in midlife-onset major and minor depression, Arch Gen Psychiatry, 62, 154, 10.1001/archpsyc.62.2.154

Strous, 2003, Dehydroepiandrosterone augmentation in the management of negative, depressive, and anxiety symptoms in schizophrenia, Arch Gen Psychiatry, 60, 133, 10.1001/archpsyc.60.2.133

Strous, 2007, Analysis of clinical symptomatology, extrapyramidal symptoms and neurocognitive dysfunction following dehydroepiandrosterone (DHEA) administration in olanzapine treated schizophrenia patients: a randomized, double-blind placebo controlled trial, Psychoneuroendocrinology, 32, 96, 10.1016/j.psyneuen.2006.11.002

Peixoto, 2014, The effects of dehydroepiandrosterone (DHEA) in the treatment of depression and depressive symptoms in other psychiatric and medical illnesses: a systematic review, Curr Drug Targets, 15, 901, 10.2174/1389450115666140717111116

Alkatib, 2009, A systematic review and meta-analysis of randomized placebo-controlled trials of DHEA treatment effects on quality of life in women with adrenal insufficiency, J Clin Endocrinol Metab, 94, 3676, 10.1210/jc.2009-0672

Genazzani, 2004, Long-term low-dose dehydroepiandrosterone replacement therapy in aging males with partial androgen deficiency, Aging Male, 7, 133, 10.1080/13685530412331284669

Brooke, 2006, Dehydroepiandrosterone (DHEA) replacement reduces growth hormone (GH) dose requirement in female hypopituitary patients on GH replacement, Clin Endocrinol, 65, 673, 10.1111/j.1365-2265.2006.02648.x

Sripada, 2013, DHEA enhances emotion regulation neurocircuits and modulates memory for emotional stimuli, Neuropsychopharmacology, 38, 1798, 10.1038/npp.2013.79

Yoon, 2010, An increase in spinal dehydroepiandrosterone sulfate (DHEAS) enhances NMDA-induced pain via phosphorylation of the NR1 subunit in mice: involvement of the sigma-1 receptor, Neuropharmacology, 59, 460, 10.1016/j.neuropharm.2010.06.007

Wang, 2009, Differential regulation of dehydroepiandrosterone and estrogen on bone and uterus in ovariectomized mice, Osteoporos Int, 20, 79, 10.1007/s00198-008-0631-1

Gentilini, 2018, Inhibition of osteoblast function by Brucella abortusis reversed by dehydroepiandrosterone and involves ERK1/2 and estrogen receptor, Front Immunol Frontiers, 9, 88, 10.3389/fimmu.2018.00088

Jankowski, 2019, Sex-specific effects of dehydroepiandrosterone (DHEA) on bone mineral density and body composition: a pooled analysis of four clinical trials, Clin Endocrinol, 90, 293, 10.1111/cen.13901

Villareal, 2002, Effects of dehydroepiandrosterone on bone mineral density: what implications for therapy?, Treat Endocrinol, 1, 349, 10.2165/00024677-200201060-00001

Wang, 2007, Dehydroepiandrosterone improves murine osteoblast growth and bone tissue morphometry via mitogen-activated protein kinase signaling pathway independent of either androgen receptor or estrogen receptor, J Mol Endocrinol, 38, 467, 10.1677/jme.1.02173

Callies, 2001, Dehydroepiandrosterone replacement in women with adrenal insufficiency: effects on body composition, serum leptin, bone turnover, and exercise capacity, J Clin Endocrinol Metab, 86, 1968, 10.1210/jcem.86.5.7483

Dhatariya, 2005, Effect of dehydroepiandrosterone replacement on insulin sensitivity and lipids in hypoadrenal women, Diabetes, 54, 765, 10.2337/diabetes.54.3.765

Gurnell, 2008, Long-term DHEA replacement in primary adrenal insufficiency: a randomized, controlled trial, J Clin Endocrinol Metab, 93, 400, 10.1210/jc.2007-1134

Villareal, 2000, Effects of DHEA replacement on bone mineral density and body composition in elderly women and men, Clin Endocrinol, 53, 561, 10.1046/j.1365-2265.2000.01131.x

Sun, 2002, Treatment of osteoporosis in men using dehydroepiandrosterone sulfate, Chin Med J, 115, 402

Mühlen, 2008, Effect of dehydroepiandrosterone supplementation on bone mineral density, bone markers, and body composition in older adults: the DAWN trial, Osteoporos Int, 19, 699, 10.1007/s00198-007-0520-z

Jankowski, 2006, Effects of dehydroepiandrosterone replacement therapy on bone mineral density in older adults: a randomized, controlled trial, J Clin Endocrinol Metab, 91, 2986, 10.1210/jc.2005-2484

Morales, 1998, The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age-advanced men and women, Clin Endocrinol, 49, 421, 10.1046/j.1365-2265.1998.00507.x

Yen, 1995, Replacement of DHEA in aging men and women. Potential remedial effects, Ann N Y Acad Sci, 774, 128, 10.1111/j.1749-6632.1995.tb17377.x

Villareal, 2004, Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial, JAMA, 292, 2243, 10.1001/jama.292.18.2243

van Thiel, 2005, Effects of dehydroepiandrostenedione, superimposed on growth hormone substitution, on quality of life and insulin-like growth factor I in patients with secondary adrenal insufficiency: a randomized, placebo-controlled, cross-over trial, J Clin Endocrinol Metab, 90, 3295, 10.1210/jc.2004-1802

Srinivasan, 2009, Effect of dehydroepiandrosterone replacement on lipoprotein profile in hypoadrenal women, J Clin Endocrinol Metab, 94, 761, 10.1210/jc.2008-1774

Christiansen, 2005, Very short term dehydroepiandrosterone treatment in female adrenal failure: impact on carbohydrate, lipid and protein metabolism, Eur J Endocrinol, 152, 77, 10.1530/eje.1.01810

Coutinho, 2011, The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights, Mol Cell Endocrinol, 335, 2, 10.1016/j.mce.2010.04.005

Demling, 1999, Comparison of the anabolic effects and complications of human growth hormone and the testosterone analog, oxandrolone, after severe burn injury, Burns, 25, 215, 10.1016/S0305-4179(98)00159-4

Reeves, 2016, Five-year outcomes after long-term oxandrolone administration in severely burned children: a randomized clinical trial, Shock, 45, 367, 10.1097/SHK.0000000000000517

Gervasio, 2000, Oxandrolone in trauma patients, Pharmacotherapy, 20, 1328, 10.1592/phco.20.17.1328.34889

Li, 2016, The efficacy and safety of oxandrolone treatment for patients with severe burns: a systematic review and meta-analysis, Burns, 42, 717, 10.1016/j.burns.2015.08.023

Miller, 2009, Oxandrolone treatment in adults with severe thermal injury, Pharmacotherapy, 29, 213, 10.1592/phco.29.2.213

Johnson, 1975, Sex and age differences in human platelet aggregation, Nature, 253, 355, 10.1038/253355a0

Muller, 2004, Endogenous sex hormones and progression of carotid atherosclerosis in elderly men, Circulation, 109, 2074, 10.1161/01.CIR.0000125854.51637.06

Merritt, 2012, Administration of dehydroepiandrosterone (DHEA) increases serum levels of androgens and estrogens but does not enhance short-term memory in post-menopausal women, Brain Res, 1483, 54, 10.1016/j.brainres.2012.09.015

Genazzani, 2007, Might DHEA be considered a beneficial replacement therapy in the elderly?, Drugs Aging, 24, 173, 10.2165/00002512-200724030-00001

Bowers, 1999, Oral dehydroepiandrosterone supplementation can increase the testosterone/epitestosterone ratio, Clin Chem, 45, 295, 10.1093/clinchem/45.2.295

Gingell, 1995, Placebo controlled double-blind study to test the efficacy of the aromatase inhibitor atamestane in patients with benign prostatic hyperplasia not requiring operation. The Schering 90.062 Study Group, J Urol, 154, 399, 10.1016/S0022-5347(01)67061-7

Forman, 2015, Elevated progesterone levels in women on DHEA supplementation likely represent assay interference, J Assist Reprod Genet, 32, 661, 10.1007/s10815-015-0442-1

Elke, 2015, Gastric residual volume in critically ill patients: a dead marker or still alive?, Nutr Clin Pract, 30, 59, 10.1177/0884533614562841

Labrie, 2016, Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause, Menopause, 23, 243, 10.1097/GME.0000000000000571

Labrie, 2008, Changes in serum DHEA and eleven of its metabolites during 12-month percutaneous administration of DHEA, J Steroid Biochem Mol Biol, 110, 1, 10.1016/j.jsbmb.2008.02.003

Li, 2001, Dehydroepiandrosterone (DHEA) reduces neuronal injury in a rat model of global cerebral ischemia, Brain Res, 888, 263, 10.1016/S0006-8993(00)03077-8

Wren, 2003, Pharmacokinetics of estradiol, progesterone, testosterone and dehydroepiandrosterone after transbuccal administration to postmenopausal women, Climacteric, 6, 104, 10.1080/cmt.6.2.104.111

Tummala, 1999, Correlation between the administered dose of DHEA and serum levels of DHEA and DHEA-S in human volunteers: analysis of published data, Clin Biochem, 32, 355, 10.1016/S0009-9120(99)00021-1

Arlt, 1998, Oral dehydroepiandrosterone for adrenal androgen replacement: pharmacokinetics and peripheral conversion to androgens and estrogens in young healthy females after dexamethasone suppression, J Clin Endocrinol Metab, 83, 1928, 10.1210/jcem.83.6.4850

Gupta, 2012, A Comparative Study of CEE, Tibolone, and DHEA as Hormone Replacement Therapy for Surgical Menopause, The Journal of Obstetrics and Gynecology of India, 63, 194, 10.1007/s13224-012-0297-7

El-Alfy, 2010, Skin responses to topical dehydroepiandrosterone: implications in antiageing treatment?, Br J Dermatol., 163, 968, 10.1111/j.1365-2133.2010.09972.x

Forsblad-d'Elia, 2009, Low serum levels of sex steroids are associated with disease characteristics in primary Sjogren's syndrome; supplementation with dehydroepiandrosterone restores the concentrations, J Clin Endocrinol Metab, 94, 2044, 10.1210/jc.2009-0106

Nestler, 1988, Dehydroepiandrosterone reduces serum low density lipoprotein levels and body fat but does not alter insulin sensitivity in normal men, J Clin Endocrinol Metab, 66, 57, 10.1210/jcem-66-1-57

Nair, 2006, DHEA in elderly women and DHEA or testosterone in elderly men, N Engl J Med, 355, 1647, 10.1056/NEJMoa054629

Vogiatzi, 1996, Dehydroepiandrosterone in morbidly obese adolescents: effects on weight, body composition, lipids, and insulin resistance, Metabolism, 45, 1011, 10.1016/S0026-0495(96)90272-3

Piketty, 2001, Double-blind placebo-controlled trial of oral dehydroepiandrosterone in patients with advanced HIV disease, Clin Endocrinol, 55, 325, 10.1046/j.1365-2265.2001.01310.x