Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader

Cell Chemical Biology - Tập 27 Số 1 - Trang 47-56.e15 - 2020
Frances Potjewyd1, Anne‐Marie W. Turner2, Joshua Beri3, Justin M. Rectenwald1,4, Jacqueline L. Norris‐Drouin1, Stephanie H. Cholensky1, David M. Margolis5,6,2, Kenneth H. Pearce1, Laura E. Herring3, Lindsey I. James1,7
1Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
2UNC HIV Cure Center, Institute of Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
3UNC Proteomics Core Facility, Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
4Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
5Department of Medicine, School Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
6Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
7Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA

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