Degeneration and regeneration in teased nerve fibres
Tóm tắt
The pattern of myelin degeneration and regeneration was studied in 40 nerve biopsy or necropsy specimens, using the teased fibre method, including 35 specimens of leprous neuritis, and 5 control specimens, 3 from humans and 2 from monkeys. The specimens of leprous nerves were derived from 10 lepromatous, borderline, or tuberculoid cases in an advanced polyneuritic stage. Nearly two-thirds showed Wallerian degeneration, which was very frequent in all types of leprosy. Segmental demyelination was observed in about one-fourth of the specimens and was more frequent in lepromatous cases. Regeneration was frequently encountered in nerve specimens from cases of all types of leprous neuritis. There was more often regeneration after Wallerian degeneration in the form of thin fibres with short uniform internodes, than an irregular remyelination after segmental demyelination. The two were further distinguished from one another by measuring the internodal lengths and fibre diameters. Extensive Schwann sheath proliferation was observed in almost all specimens of leprosy; the non-specificity of this is stressed. The significance of studying degenerative and regenerative changes at different levels of the same nerve from leprous neuritis, is discussed. The findings have shown that the myelin of the distal-most parts of the nerves sustains more severe damage, confirming earlier similar observations on paraffin sections. The control specimens, 3 of which were fixed in formalin for prolonged periods, did not show any significant abnormalities in the myelin.
Tài liệu tham khảo
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