Definition of the Clinical Spectrum of Kernicterus and Bilirubin-Induced Neurologic Dysfunction (BIND)

Levine RL, Fredericks WR, Rapoport SI . Clearance of bilirubin from rat brain after reversible osmotic opening of the blood–brain barrier. Pediatr Res 1985;19(10):1040–1043.

Ostrow JD, Pascolo L, Shapiro SM, Tiribelli C . New concepts of bilirubin encephalopathy. Eur J Clin Invest 2003;33(11):988–997.

Ostrow JD, Pascolo L, Tiribelli C . Reassessment of the unbound concentrations of unconjugated bilirubin in relation to neurotoxicity in vitro. Pediatr Res 2003;54(1):98–104.

Conlee JW, Shapiro SM . Development of cerebellar hypoplasia in jaundiced Gunn rats treated with sulfadimethoxine: a quantitative light microscopic analysis. Acta Neuropathol 1997;93:450–460.

Churn SB, DeLorenzo RJ, Shapiro SM . Bilirubin induces a calcium-dependent inhibition of multifunctional Ca2+/calmodulin-dependent kinase II activity in vitro. Pediatr Res 1995;38:949–954.

Conlee JW, Shapiro SM, Churn SB . Expression of the alpha and beta subunits of Ca2+/calmodulin kinase II in the cerebellum of jaundiced Gunn rats during development: a quantitative light microscopic analysis. Acta Neuropathol (Berl) 2000;99(4):393–401.

Shaia WT, Shapiro SM, Heller AJ, Galiani DL, Sismanis A, Spencer RF . Immunohistochemical localization of calcium-binding proteins in the brainstem vestibular nuclei of the jaundiced Gunn rat. Hear Res 2002;173(1–2):82–90.

Spencer RF, Shaia WT, Gleason AT, Sismanis A, Shapiro SM . Changes in calcium-binding protein expression in the auditory brainstem nuclei of the jaundiced Gunn rat. Hear Res 2002;171(1–2):129–141.

Shapiro SM, Churn SB, Pal S, Limbrick DD, De Lorenzo RJ . Bilirubin alters intracellular calcium homeostasis. Pediatr Res 1998;42(42, Part 2):195A.

Johnston MV, Hoon Jr AH . Possible mechanisms in infants for selective basal ganglia damage from asphyxia, kernicterus, or mitochondrial encephalopathies. J Child Neurol 2000;15(9):588–591.

Volpe JJ . Bilirubin and brain injury. In: Volpe JJ. editor. Neurology of the Newborn. Philadelphia: WB Saunders; 2001. p. 490–514.

Wennberg RP, Ahlfors CE, Bickers R, McMurtry CA, Shetter JL . Abnormal auditory brainstem response in a newborn infant with hyperbilirubinemia: improvement with exchange transfusion. J Pediatr 1982;100(4):624–626.

Nwaesei CG, Van Aerde J, Boyden M, Perlman M . Changes in auditory brainstem responses in hyperbilirubinemic infants before and after exchange transfusion. Pediatr 1984;74(5):800–803.

Shapiro SM, Nakamura H . Bilirubin and the auditory system. J Perinatol 2001;21(Suppl 1):S52–S55 (discussion S59–62).

Starr A, Picton TW, Sininger Y, Hood LJ, Berlin CI . Auditory neuropathy. Brain 1996;119(Part 3):741–753.

Deltenre P, Mansbach AL, Bozet C, Clercx A, Hecox KE . Auditory neuropathy: a report on three cases with early onsets and major neonatal illnesses. Electroencephalogr Clin Neurophysiol 1997;104(1):17–22.

Berlin CI, Bordelon J, St John P, et al. Reversing click polarity may uncover auditory neuropathy in infants. Ear Heart 1998;19(1):37–47.

Berlin CI, Morlet T, Hood LJ . Auditory neuropathy/dyssynchrony: its diagnosis and management. Pediatr Clin North Am 2003;50(2:331–340 vii–viii.

Chisin R, Perlman M, Sohmer H . Cochlear and brain stem responses in hearing loss following neonatal hyperbilirubinemia. Ann Otol 1979;88:352–357.

Volpe JJ . Bilirubin and brain injury. In: Volpe JJ. editor. Neurology of the Newborn. Philadelphia: WB Saunders Co; 1981. p. 336–356.

Hyman CB, Keaster J, Hanson V, et al. CNS abnormalities after neonatal hemolytic disease or hyperbilirubinemia. A prospective study of 405 patients. Am J Dis Child 1969;117:395–405.

Johnson L, Boggs TR . Bilirubin-dependent brain damage: Incidence and indications for treatment. In: Odell GB, Schaffer R, Sionpoulous AP. editors. Phototherapy in the Newborn: An Overview 1974. Washington: National Academy of Sciences. p. 122–149.

Naeye RL . Amniotic fluid infections, neonatal hyperbilirubinemia and psychomotor impairment. Pediatr 1978;62:497–503.

Odell GB, Storey GN, Rosenberg LA . Studies in kernicterus III. The saturation of serum proteins with bilirubin during neonatal life and its relationship to brain damage at five years. J Pediatr 1970;76:12–21.

Rubin RA, Balow B, Fisch RO . Neonatal serum bilirubin levels related to cognitive development at ages 4 through 7 years. J Pediatr 1979;94(4):601–604.

Scheidt PC . Toxicity to bilirubin in neonates: infant development during first year in relation to maximal neonatal serum bilirubin concentration. J Pediatr 1977;92:292–297.

Bergman I, Hirsch RP, Fria TJ, Shapiro SM, Holzman I, Painter MJ . Cause of hearing loss in the high-risk premature infant. J Pediatr 1985;106(1):5–101.

Salamy A, Eldredge L, Tooley WH . Neonatal status and hearing loss in high-risk infants. J Pediatr 1989;114(5):847–852.

Rance G, Beer DE, Cone-Wesson B, et al. Clinical findings for a group of infants and young children with auditory neuropathy. Ear Heart 1999;20(3):238–252.

Simmons JL, Beauchaine KL . Auditory neuropathy: case study with hyperbilirubinemia. J Am Acad Audiol 2000;11(6):337–347.

de Vries LS, Lary S, Whitelaw AG, Dubowitz LM . Relationship of serum bilirubin levels and hearing impairment in newborn infants. Early Hum Dev 1987;15(5):269–277.

de Vries LS, Lary S, Dubowitz LMS . Relationship of serum bilirubin levels to ototoxicity and deafness in high-risk, low birth-weight infants. Pediatr 1985;76(3):351–354.

Seidman DS, Paz I, Stevenson DK, Laor A, Danon YL, Gale R . Neonatal hyperbilirubinemia and physical and cognitive performance at 17 years of age. Pediatr 1991;88(4):828–833.

Yilmaz Y, Degirmenci S, Akdas F, et al. Prognostic value of auditory brainstem response for neurologic outcome in patients with neonatal indirect hyperbilirubinemia. J Child Neurol 2001;16(10):772–775.

Stein L, Tremblay K, Pasternak J, Banerjee S, Lindemann K . Auditory brainstem neuropathy and elevated bilirubin levels. Semin Hearing 1996;17:197–213.

Shapiro SM, Rosen JR, Dixon KT . Auditory brainstem response (ABR) abnormalities and auditory neuropathy in children with kernicterus. Pediatr Res 2002;51(4 Part 2):340A.

Shapiro SM, Daymont MJ . Patterns of kernicterus related to neonatal hyperbilirubinemia and gestational age. Pediatr Res 2003;53(4 Part 2):398A–399A.

Shallop JK, Peterson A, Facer GW, Fabry LB, Driscoll CL . Cochlear implants in five cases of auditory neuropathy: postoperative findings and progress. Laryngoscope 2001;111(4 Part 1):555–562.