Deficiency of vitamin D and its relation with clinical and laboratory activity of inflammatory bowel diseases

Journal of Coloproctology - Tập 38 - Trang 99-104 - 2018
Bruno Lorenzo Scolaro1, Claiza Barretta1, Cristina Henschel Matos1, Everson Fernando Malluta1, Isadora Bampi Tavares de Almeida1, Laura Domingues Braggio1, Sueli Bobato1, Clarice Maria Specht1
1Universidade do Vale do Itajaí, Itajaí, SC, Brazil

Tóm tắt

Abstract

Objective To evaluate the serum concentrations of vitamin D and their relation with inflammatory bowel diseases.

Methods This is a quantitative and descriptive study, with individuals assisted by the interdisciplinary ambulatory of Inflammatory Bowel Disease of the Family and Community Health Unit of Itajaí/SC from September 2015 to October 2016. Socioeconomic data, life habits, and biochemical tests were collected, with the use of clinical indexes of classification of the disease activity: Harvey-Bradshaw Index (Crohn's Disease) and Partial Mayo Score (Chronic Nonspecific Ulcerative Colitis).

Results Of the 60 patients evaluated, 57% (n = 34) had Crohn's Disease and 43% (n = 26) had Chronic Nonspecific Ulcerative Colitis. According to disease activity, 75% (n = 45) were in the remission phase, 13% (n = 8) had mild activity, and 9% (n = 5) had moderate activity. Regarding vitamin D, 63% (n = 38) had deficiency of this vitamin and 37% (n = 22) presented sufficiency. With the association of serum vitamin D concentrations and disease activity, we observed statistical significance among the variables (p = 0.005). Regarding biochemical exams, the majority of patients with fecal calprotectin elevation presented vitamin D deficiency (p = 0.025). Statistically significant correlation between HSV and vitamin D (p = 0.0001) was found.

Conclusion According to the findings of this study, vitamin D deficiency is related to the clinical and laboratory activity of inflammatory bowel diseases.


Tài liệu tham khảo

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