Deficiency of Stomach-Type Claudin-18 in Mice Induces Gastric Tumor Formation Independent of H pylori Infection

Koya Suzuki1,2, Kazuhiro Sentani3, Hiroo Tanaka1, Tomoki Yano1, Kazuo Suzuki4, Masanobu Oshima5, Wataru Yasui3, Atsushi Tamura1, Sachiko Tsukita1
1Laboratory of Biological Science, Graduate School of Frontier Biosciences, and Graduate School of Medicine, Osaka University, Osaka, Japan
2Research Institute for Diseases of Old Age and Department of Clinical Laboratory Medicine, Graduate School of Medicine, Juntendo University, Tokyo, Japan
3Department of Molecular Pathology, Hiroshima University, Institute of Biomedical and Health Sciences, Hiroshima, Japan
4Department of Health Protection, Graduate School of Medicine, Asia International Institute of Infectious Disease Control, Teikyo University, Tokyo, Japan
5Division of Genetics, Cancer Research Institute, and Nano Life Science Institute, Kanazawa University, Kanazawa, Japan

Tài liệu tham khảo

Correia, 2012, The tumor microenvironment is a dominant force in multidrug resistance, Drug Resist Updat, 15, 39, 10.1016/j.drup.2012.01.006 Fidler, 1977, Metastasis results from preexisting variant cells within a malignant tumor, Science, 197, 893, 10.1126/science.887927 Joyce, 2009, Microenvironmental regulation of metastasis, Nat Rev Cancer, 9, 239, 10.1038/nrc2618 Bhat, 2014, Of plasticity and specificity: dialectics of the microenvironment and macroenvironment and the organ phenotype, Wiley Interdiscip Rev Membr Transp Signal, 3, 147 Frank, 2012, Claudins and alveolar epithelial barrier function in the lung, Ann N Y Acad Sci, 1257, 175, 10.1111/j.1749-6632.2012.06533.x Abu-Odeh, 2014, Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks, J Biol Chem, 289, 8865, 10.1074/jbc.M113.506790 Tsukita, 2001, Multifunctional strands in tight junctions, Nat Rev Mol Cell Biol, 2, 285, 10.1038/35067088 Shen, 2012, Tight junctions on the move: molecular mechanisms for epithelial barrier regulation, Ann N Y Acad Sci, 1258, 9, 10.1111/j.1749-6632.2012.06613.x Suzuki, 2015, Model for the architecture of claudin-based paracellular ion channels through tight junctions, J Mol Biol, 427, 291, 10.1016/j.jmb.2014.10.020 Peek, 2016, Hellicobactor pylori and gastrointestinal tract adenocarcinomas, Nat Rev Cancer, 2, 387 Higashi, 2004, Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation, J Biol Chem, 279, 17205, 10.1074/jbc.M309964200 Takahashi, 2011, SHP2 tyrosine phosphatase converts parafibromin/Cdc73 from a tumor suppressor to an oncogenic driver, Mol Cell, 43, 45, 10.1016/j.molcel.2011.05.014 Saadat, 2007, Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity, Nature, 447, 330, 10.1038/nature05765 Hayashi, 2012, Deficiency of claudin–18 causes paracellular H+leakage, upregulation of interleukin–1β, and atrophic gastritis in mice, Gastroenterology, 142, 292, 10.1053/j.gastro.2011.10.040 Mineta, 2011, Predicted expansion of the claudin multigene family, FEBS Lett, 585, 606, 10.1016/j.febslet.2011.01.028 Tsukita, 1999, Structural and signalling molecules come together at tight junctions, Curr Opin Cell Biol, 11, 628, 10.1016/S0955-0674(99)00016-2 Tanaka, 2015, Intestinal deletion of claudin-7 enhances paracellular organic solute flux and initiates colonic inflammation in mice, Gut, 64, 1529, 10.1136/gutjnl-2014-308419 Matsumoto, 2014, Claudin 2 deficiency reduces bile flow and increases susceptibility to cholesterol gallstone disease in mice, Gastroenterology, 147, 1134, 10.1053/j.gastro.2014.07.033 Wada, 2013, Loss of claudins 2 and 15 from mice causes defects in paracellular Na+flow and nutrient transport in gut and leads to death from malnutrition, Gastroenterology, 144, 369, 10.1053/j.gastro.2012.10.035 Tamura, 2014, Paracellular barrier and channel functions of TJ claudins in organizing biological systems: advances in the field of barriology revealed in knockout mice, Semin Cell Dev Biol, 36, 177, 10.1016/j.semcdb.2014.09.019 Tokumasu, 2016, Dose-dependent role of claudin–1 in vivo in orchestrating features of atopic dermatitis, Proc Natl Acad Sci U S A, 113, E4061, 10.1073/pnas.1525474113 Van Itallie, 2006, Claudins and epithelial paracellular transport, Annu Rev Physiol, 68, 403, 10.1146/annurev.physiol.68.040104.131404 Guillemot, 2008, The cytoplasmic plaque of tight junctions: a scaffolding and signalling center, Biochim Biophys Acta, 1778, 601, 10.1016/j.bbamem.2007.09.032 Yao, 2015, Recurrent fusion genes in gastric cancer: CLDN18-ARHGAP26 induces loss of epithelial integrity, Cell Rep, 12, 272, 10.1016/j.celrep.2015.06.020 Tsukita, 2019, The claudins: from tight junctions to biological systems, Trends Biochem Sci, 44, 141, 10.1016/j.tibs.2018.09.008 Multhoff, 2012, Chronic inflammation in cancer development, Front Immunol, 2, 1, 10.3389/fimmu.2011.00098 Hagen, 2018, Loss of tight junction protein Claudin 18 promotes progressive neoplasia development in mouse stomach, Gastroenterology, 1 Zhang, 2017, From inflammation to gastric cancer: role of Helicobacter pylori, Oncol Lett, 13, 543, 10.3892/ol.2016.5506 Nakagawa, 2014, ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development, Cancer Cell, 26, 331, 10.1016/j.ccr.2014.07.001 Katoh, 2013, CXCR2-expressing myeloid-derived suppressor cells are essential to promote colitis-associated tumorigenesis, Cancer Cell, 24, 631, 10.1016/j.ccr.2013.10.009 Takahashi, 2010, Tumor necrosis factor-?? regulates transforming growth factor-??-dependent epithelial-mesenchymal transition by promoting hyaluronan-CD44-moesin interaction, J Biol Chem, 285, 4060, 10.1074/jbc.M109.056523 Yamanoi, 2015, Epigenetic clustering of gastric carcinomas based on dna methylation profiles at the precancerous stage: Its correlation with tumor aggressiveness and patient outcome, Carcinogenesis, 36, 509, 10.1093/carcin/bgv013 Lamouille, 2014, Molecular mechanisms of epithelial-mesenchymal transition, Nat Rev Mol Cell Biol, 15, 178, 10.1038/nrm3758 Zhou, 2015, CXCR2/CXCL5 axis contributes to epithelial-mesenchymal transition of HCC cells through activating PI3K/Akt/GSK-3β/Snail signaling, Cancer Lett, 358, 124, 10.1016/j.canlet.2014.11.044 Ohata, 2004, Progression of chronic atrophic gastritis associated with Helicobacter pylori infection increases risk of gastric cancer, Int J Cancer, 109, 138, 10.1002/ijc.11680 Tye, 2012, STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation, Cancer Cell, 22, 466, 10.1016/j.ccr.2012.08.010 Bromberg, 2009, Inflammation and cancer: IL-6 and STAT3 complete the Link, Cancer Cell, 15, 79, 10.1016/j.ccr.2009.01.009 Groisman, 2014, Metastatic carcinoma occurring in a gastric hyperplastic polyp mimicking primary gastric cancer: the first reported case, Case Rep Pathol, 2014, 1, 10.1155/2014/781318 Barham, 2015, Aberrant activation of NF-κB signaling in mammary epithelium leads to abnormal growth and ductal carcinoma in situ, BMC Cancer, 15, 1, 10.1186/s12885-015-1652-8 Hansson, 2008, CCL28 is increased in human Helicobacter pylori-induced gastritis and mediates recruitment of gastric immunoglobulin A-secreting cells, Infect Immun, 76, 3304, 10.1128/IAI.00041-08 Thomas, 2015, Structure-function analysis of CCL28 in the development of post-viral asthma, J Biol Chem, 290, 4528, 10.1074/jbc.M114.627786 Facciabene, 2011, Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Tregcells, Nature, 475, 226, 10.1038/nature10169 Huaman, 2015, CCL28 chemokine: An anchoring point bridging innate and adaptive immunity, Int Immunopharmacol, 143, 951 Daubeuf, 2015, Protective effect of a protein epitope mimetic CCR10 antagonist, POL7085, in a model of allergic eosinophilic airway inflammation, Respir Res, 16, 1, 10.1186/s12931-015-0231-5 Buelow, 2017, POL7085 or anti-CCL28 treatment inhibits development of post-paramyxoviral airway disease, Immun Inflamm Dis, 5, 98, 10.1002/iid3.147 Zavros, 2017, Initiation and maintenance of gastric cancer: a focus on CD44 variant isoforms and cancer stem cells, Cell Mol Gastroenterol Hepatol, 4, 55, 10.1016/j.jcmgh.2017.03.003 Li, 2016, Gastrointestinal stem cells in health and disease: from flies to humans, Dis Model Mech, 9, 487 Seishima, 2015, Ink4a/arf-dependent loss of parietal cells induced by oxidative stress promotes CD44-dependent gastric tumorigenesis, Cancer Prev Res (Phila), 8, 492, 10.1158/1940-6207.CAPR-15-0025-T Wada, 2013, Functional role of CD44v-xCT system in the development of spasmolytic polypeptide–expressing metaplasia, Cancer Sci, 104, 1323, 10.1111/cas.12236 Echizen, 2016, Inflammation in gastric cancer: Interplay of the COX-2/prostaglandin E2and Toll-like receptor/MyD88 pathways, Cancer Sci, 107, 391, 10.1111/cas.12901 Schuijers, 2015, Ascl2 acts as an R-spondin/wnt-responsive switch to control stemness in intestinal crypts, Cell Stem Cell, 16, 158, 10.1016/j.stem.2014.12.006 Weis, 2009, Current understanding of SPEM and its standing in the preneoplastic process, Gastric Cancer, 12, 189, 10.1007/s10120-009-0527-6 Holmes, 2006, Claudin profiling in the mouse during postnatal intestinal development and along the gastrointestinal tract reveals complex expression patterns, Gene Expr Patterns, 6, 581, 10.1016/j.modgep.2005.12.001 Petersen, 2017, Murine models of gastric corpus preneoplasia, Cell Mol Gastroenterol Hepatol, 3, 11, 10.1016/j.jcmgh.2016.11.001 Shimizu, 2016, Characterization of progressive metaplasia in the gastric corpus mucosa of Mongolian gerbils infected with Helicobacter pylori, J Pathol, 239, 399, 10.1002/path.4735 Chiurillo, 2015, Role of the Wnt/β-catenin pathway in gastric cancer: an in-depth literature review, World J Exp Med, 5, 84, 10.5493/wjem.v5.i2.84 Mao, 2014, Roles of Wnt/β-catenin signaling in the gastric cancer stem cells proliferation and salinomycin treatment, Cell Death Dis, 5, 1, 10.1038/cddis.2013.515 Brabletz, 1999, B-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer, Am J Pathol, 155, 1033, 10.1016/S0002-9440(10)65204-2 Zhao, 2017, Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3β/β-catenin pathways, Mol Cancer, 16, 1, 10.1186/s12943-017-0629-4 Valkenburg, 2011, Wnt/β-catenin signaling in normal and cancer stem cells, Cancers, 3, 2050, 10.3390/cancers3022050 Oshima, 2006, Carcinogenesis in mouse stomach by simultaneous activation of the Wnt signaling and prostaglandin E2 pathway, Gastroenterology, 131, 1086, 10.1053/j.gastro.2006.07.014 Markowski, 2016, Pathophysiological and clinical aspects of gastric hyperplastic polyps, World J Gastroenterol, 22, 8883, 10.3748/wjg.v22.i40.8883 Velázquez-Dohorn, 2018, Changing trends in gastric polyps, Rev Invest Clin, 70, 40 Kopacova, 2009, Peutz-Jeghers syndrome: diagnostic and therapeutic approach, World J Gastroenterol, 15, 5397, 10.3748/wjg.15.5397 Phesse, 2017, Lgr5 joins the club of gastric stem cell markers in the corpus, Nat Cell Biol, 19, 752, 10.1038/ncb3567 Leushacke, 2017, Lgr5-expressing chief cells drive epithelial regeneration and cancer in the oxyntic stomach, Nat Cell Biol, 19, 774, 10.1038/ncb3541 Kinoshita, 2017, Metaplasia in the stomach—precursor of gastric Cancer?, Int J Mol Sci, 18, E2063, 10.3390/ijms18102063 Mittal, 2018, Epithelial mesenchymal transition in tumor metastasis, Annu Rev Pathol, 13, 395, 10.1146/annurev-pathol-020117-043854 Demitrack, 2017, Notch as a driver of gastric epithelial cell proliferation, Cell Mol Gastroenterol Hepatol, 3, 323, 10.1016/j.jcmgh.2017.01.012 Zhou, 2018, Claudin-18 – mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis Find the latest version: Claudin-18 – mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis, J Clin Invest, 128, 970, 10.1172/JCI90429