Deficiencies of folate and vitamin B12 do not affect fracture healing in mice

Bone - Tập 47 - Trang 151-155 - 2010
J.H. Holstein1,2, M. Herrmann3,4, J. Schmalenbach1,2, R. Obeid3, I. Ölkü5, M. Klein1, P. Garcia1,2, T. Histing1,2, T. Pohlemann1, M.D. Menger2, W. Herrmann3, L. Claes5
1Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg/Saar, Germany
2Institute for Clinical and Experimental Surgery, University of Saarland, Homburg/Saar, Germany
3Department of Clinical Chemistry and Laboratory Medicine, University of Saarland, Homburg/Saar, Germany
4ANZAC Research Institute, University of Sydney, Sydney, Australia
5Institute of Orthopaedic Research and Biomechanics, University of Ulm, Germany

Tài liệu tham khảo

Herrmann, 2001, The importance of hyperhomocysteinemia as a risk factor for diseases: an overview, Clin Chem Lab Med, 39, 666, 10.1515/CCLM.2001.110 Herrmann, 2007, The role of hyperhomocysteinemia as well as folate, vitamin B(6) and B(12) deficiencies in osteoporosis - a systematic review, Clin Chem Lab Med, 45, 1621, 10.1515/CCLM.2007.362 Finkelstein, 1998, The metabolism of homocysteine: pathways and regulation, Eur J Pediatr, 157, S40, 10.1007/PL00014300 Refsum, 2004, Facts and recommendations about total homocysteine determinations: an expert opinion, Clin Chem, 50, 3, 10.1373/clinchem.2003.021634 Stanger, 2003, DACH-LIGA Homocystein eV (German, Austrian and Swiss homocysteine society): consensus paper on the rational clinical use of homocysteine, folic acid and B vitamins in cardiovascular and thrombotic diseases: guidelines and recommendations, Clin Chem Lab Med, 41, 1392, 10.1515/CCLM.2003.214 De Bree, 2001, Lifestyle factors and plasma homocysteine concentrations in a general population sample, Am J Epidemiol, 154, 150, 10.1093/aje/154.2.150 Gonzalez-Gross, 2007, B-vitamins and homocysteine in Spanish institutionalized elderly, Int J Vitam Nutr Res, 77, 22, 10.1024/0300-9831.77.1.22 Herrmann, 1999, Hyperhomocysteinemia in high-aged subjects: relation of B-vitamins, folic acid, renal function and the methylenetetrahydrofolate reductase mutation, Atherosclerosis, 144, 91, 10.1016/S0021-9150(99)00036-2 Dhonukshe-Rutten, 2005, Homocysteine and vitamin B12 status relate to bone turnover markers, broadband ultrasound attenuation, and fractures in healthy elderly people, J Bone Miner Res, 20, 921, 10.1359/JBMR.050202 Gjesdal, 2007, Plasma homocysteine, folate, and vitamin B12 and the risk of hip fracture: the Hordaland homocysteine study, J Bone Miner Res, 22, 747, 10.1359/jbmr.070210 Herrmann, 2007, Experimental hyperhomocysteinemia reduces bone quality in rats, Clin Chem, 53, 1455, 10.1373/clinchem.2007.086272 Herrmann, 2009, Hyperhomocysteinemia induces a tissue specific accumulation of homocysteine in bone by collagen binding and adversely affects bone, Bone, 44, 467, 10.1016/j.bone.2008.10.051 McLean, 2004, Homocysteine as a predictive factor for hip fracture in older persons, N Engl J Med, 350, 2042, 10.1056/NEJMoa032739 Van Meurs, 2004, Homocysteine levels and the risk of osteoporotic fracture, N Engl J Med, 350, 2033, 10.1056/NEJMoa032546 Yazdanpanah, 2007, Effect of dietary B vitamins on BMD and risk of fracture in elderly men and women: the Rotterdam study, Bone, 41, 987, 10.1016/j.bone.2007.08.021 Claes, 2009, Hyperhomocysteinemia is associated with impaired fracture healing in mice, Calcif Tissue Int, 85, 17, 10.1007/s00223-009-9262-6 Holstein, 2008, Development of a stable closed femoral fracture model in mice, J Surg Res, 153, 71, 10.1016/j.jss.2008.02.042 Müller, 1990 Obeid, 2005, Response of homocysteine, cystathionine, and methylmalonic acid to vitamin treatment in dialysis patients, Clin Chem, 51, 196, 10.1373/clinchem.2004.041210 Herbert, 1994, Staging vitamin B-12 (cobalamin) status in vegetarians, Am J Clin Nutr, 59, S1213, 10.1093/ajcn/59.5.1213S Hvas, 2006, Diagnosis and treatment of vitamin B12 deficiency—an update, Haematologica, 91, 1506 Herrmann, 2009, Experimental folate and vitamin B12 deficiency does not alter bone quality in rats, J Bone Miner Res, 24, 589, 10.1359/jbmr.081211 Hofmann, 2001, Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model, J Clin Invest, 107, 675, 10.1172/JCI10588 Babayan, 1979, Fracture healing and folic acid, Arch Orthop Trauma Surg, 94, 63, 10.1007/BF00448095 Dodds, 1986, Abnormalities in fracture healing induced by vitamin B6-deficiency in rats, Bone, 7, 489, 10.1016/8756-3282(86)90008-6 Holstein, 2009, Low serum folate and vitamin B-6 are associated with an altered cancellous bone structure in humans, Am J Clin Nutr, 90, 1440, 10.3945/ajcn.2009.28116 Finkelstein, 2000, Pathways and regulation of homocysteine metabolism in mammals, Semin Thromb Hemost, 26, 219, 10.1055/s-2000-8466 Finkelstein, 2007, Metabolic regulatory properties of S-adenosylmethionine and S-adenosylhomocysteine, Clin Chem Lab Med, 45, 1694, 10.1515/CCLM.2007.341 Caudill, 2001, Intracellular S-adenosylhomocysteine concentrations predict global DNA hypomethylation in tissues of methyl-deficient cystathionine beta-synthase heterozygous mice, J Nutr, 131, 2811, 10.1093/jn/131.11.2811 Guerra-Shinohara, 2004, Low ratio of S-adenosylmethionine to S-adenosylhomocysteine is associated with vitamin deficiency in Brazilian pregnant women and newborns, Am J Clin Nutr, 80, 1312, 10.1093/ajcn/80.5.1312 Holstein, 2009, Trauma, 23, S31