Những hiểu biết sâu sắc về nhiễm trùng đường tiết niệu và các phương pháp điều trị tự nhiên hiệu quả

African Journal of Urology - Tập 27 Số 1 - 2021
Bibi Sedigheh Fazly Bazzaz1, Sareh Darvishi Fork2, Reza Ahmadi3, Bahman Khameneh4
1Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
2School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
3Department of Family Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4Department of Pharmaceutical Control, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Tóm tắt

Tóm tắt Thông tin nền Nhiễm trùng đường tiết niệu (UTI) là một hiện tượng phổ biến ở phụ nữ, trong thời kỳ mang thai và ở những phụ nữ trong giai đoạn tiền mãn kinh và mãn kinh. UTI liên quan đến tỷ lệ bệnh tật và tử vong đáng kể, và nó ảnh hưởng đến chất lượng cuộc sống của những bệnh nhân bị ảnh hưởng. Điều trị bằng kháng sinh là một phương pháp hiệu quả và giảm thời gian triệu chứng. Sự phát triển của tình trạng kháng thuốc, các tác dụng phụ của kháng sinh và các vấn đề liên quan khác dẫn đến việc thiết lập khuôn khổ nghiên cứu để tìm ra các phương pháp thay thế trong việc kiểm soát UTI. Các phương pháp tự nhiên đã được sử dụng rộng rãi trong việc quản lý các bệnh khác nhau để cải thiện triệu chứng và nâng cao sức khỏe tổng quát. Nội dung chính Các cơ sở dữ liệu khác nhau đã được sử dụng để xác định các nghiên cứu báo cáo về các tùy chọn tự nhiên bao gồm thuốc thảo dược, vitamin, nguyên tố vi lượng, đường và probiotics mà không có giới hạn thời gian. Kết luận Các loại thuốc thảo dược có thể có hiệu quả ngay khi có dấu hiệu nhiễm trùng và cũng cho việc dự phòng trong thời gian ngắn. Việc sử dụng vitamin, nguyên tố vi lượng và/hoặc đường là một phương pháp hiệu quả trong việc ngăn ngừa UTI, và sự kết hợp của chúng với các tác nhân kháng khuẩn khác mang lại kết quả tích cực. Probiotics có tiềm năng lớn đối với mối đe dọa của việc sử dụng kháng sinh quá mức và sự phổ biến của các vi sinh vật kháng kháng sinh. Nghiên cứu này có thể hữu ích trong việc phát triển công thức điều trị hiệu quả cho UTI.

Từ khóa


Tài liệu tham khảo

Sheerin NS, Glover EK (2019) Urinary tract infection. Medicine 47:546–550

Sheerin NS (2011) Urinary tract infection. Medicine 39:384–389

Kasper DL, Fauci AS, Hauser SL, Longo DL, Jameson JL, Loscalzo J (2018) Urinary tract infections, pyelonephritis, and prostatitis. In: Harrison's principles of internal medicine, 20th edn. McGraw-Hill Education, New York

Freire MP, Martinho L, Mendes CV, Spadão F, De Paula FJ, Nahas WC, David-Neto E, Pierrotti LC (2020) Institutional protocol adherence in the incidence of recurrent urinary tract infection after kidney transplantation. J Glob Antimicrob Resist 23:352–358

Olin SJ, Bartges JW (2015) Urinary tract infections: treatment/comparative therapeutics. Vet Clin North Am Small Anim Pract 45:721–746

Behzadi P (2019) Classical chaperone-usher (CU) adhesive fimbriome: uropathogenic Escherichia coli (UPEC) and urinary tract infections (UTIs). Folia Microbiol (Praha)

Matulay JT, Mlynarczyk CM, Cooper KL (2016) Urinary tract infections in women: pathogenesis, diagnosis, and management. Curr Bladder Dysfunct Rep 11:53–60

Storme O, Tiran Saucedo J, Garcia-Mora A, Dehesa-Davila M, Naber KG (2019) Risk factors and predisposing conditions for urinary tract infection. Ther Adv Urol 11:1756287218814382

Asadi Karam MR, Habibi M, Bouzari S (2019) Urinary tract infection: pathogenicity, antibiotic resistance and development of effective vaccines against uropathogenic Escherichia coli. Mol Immunol 108:56–67

Lane DR, Takhar SS (2011) Diagnosis and management of urinary tract infection and pyelonephritis. Emerg Med Clin North Am 29:539–552

Khameneh B, Iranshahy M, Vahdati-Mashhadian N, Sahebkar A, Fazly Bazzaz BS (2019) Non-antibiotic adjunctive therapy: a promising approach to fight tuberculosis. Pharmacol Res 146:104289

Khameneh B, Diab R, Ghazvini K, Fazly Bazzaz BS (2016) Breakthroughs in bacterial resistance mechanisms and the potential ways to combat them. Microb Pathog 95:32–42

Khameneh B, Iranshahy M, Soheili V, Fazly Bazzaz BS (2019) Review on plant antimicrobials: a mechanistic viewpoint. Antimicrob Resist Infect Control 8:118

Bazzaz BSF, Fakori M, Khameneh B, Hosseinzadeh H (2019) Effects of omeprazole and caffeine alone and in combination with gentamicin and ciprofloxacin against antibiotic resistant staphylococcus aureus and Escherichia coli strains. J Pharmacopuncture 22:49–54

Fazly Bazzaz BS, Khameneh B, Zahedian Ostad MR, Hosseinzadeh H (2018) In vitro evaluation of antibacterial activity of verbascoside, lemon verbena extract and caffeine in combination with gentamicin against drug-resistant Staphylococcus aureus and Escherichia coli clinical isolates. Avicenna J Phytomed 8:246–253

Fazly Bazzaz BS, Sarabandi S, Khameneh B, Hosseinzadeh H (2016) Effect of catechins, green tea extract and methylxanthines in combination with gentamicin against Staphylococcus aureus and Pseudomonas aeruginosa: combination therapy against resistant bacteria. J Pharmacopuncture 19:312–318

Baker JH, Qiu J, Grine K (2018) Role of complementary and alternative therapies in infectious disease. Prim Care Clin Off Pract 45:533–539

Mantzorou M, Giaginis C (2018) Cranberry consumption against urinary tract infections: clinical state-of-the-art and future perspectives. Curr Pharm Biotechnol 19:1049–1063

Poulios E, Vasios GK, Psara E, Giaginis C (2020) Medicinal plants consumption against urinary tract infections: a narrative review of the current evidence. Expert Rev Anti Infect Ther 2020:1–10

Loubet P, Ranfaing J, Dinh A, Dunyach-Remy C, Bernard L, Bruyère F, Lavigne J-P, Sotto A (2020) Alternative therapeutic options to antibiotics for the treatment of urinary tract infections. Front Microbiol 11:1

Farhadi F, Khameneh B, Iranshahi M, Iranshahy M (2019) Antibacterial activity of flavonoids and their structure-activity relationship: an update review. Phytother Res 33:13–40

Shaheen G, Akram M, Jabeen F, Ali Shah SM, Munir N, Daniyal M, Riaz M, Tahir IM, Ghauri AO, Sultana S, Zainab R, Khan M (2019) Therapeutic potential of medicinal plants for the management of urinary tract infection: a systematic review. Clin Exp Pharmacol Physiol 46:613–624

Yarnell E (2002) Botanical medicines for the urinary tract. World J Urol 20:285–293

Bag A, Bhattacharyya S, Chattopadhyay R (2008) Medicinal plants and urinary tract infections: an update. Phcog Rev 2:277

Marino A, Bellinghieri V, Nostro A, Miceli N, Taviano MF, Guvenc A, Bisignano G (2010) In vitro effect of branch extracts of Juniperus species from Turkey on Staphylococcus aureus biofilm. FEMS Immunol Med Microbiol 59:470–476

Schilcher H (1995) Juniper berry oil in diseases of the efferent urinary tract? Med Monatsschr Pharm 18:198–199

Pepeljnjak S, Kosalec I, Kalodera Z, Blazevic N (2005) Antimicrobial activity of juniper berry essential oil (Juniperus communis L., Cupressaceae). Acta Pharm 55:417–422

Howell AB, Foxman B (2002) Cranberry juice and adhesion of antibiotic-resistant uropathogens. JAMA 287:3082–3083

Burger O, Ofek I, Tabak M, Weiss EI, Sharon N, Neeman I (2000) A high molecular mass constituent of cranberry juice inhibits Helicobacter pylori adhesion to human gastric mucus. FEMS Immunol Med Microbiol 29:295–301

Di Martino P, Agniel R, David K, Templer C, Gaillard JL, Denys P, Botto H (2006) Reduction of Escherichia coli adherence to uroepithelial bladder cells after consumption of cranberry juice: a double-blind randomized placebo-controlled cross-over trial. World J Urol 24:21–27

Tao Y, Pinzon-Arango PA, Howell AB, Camesano TA (2011) Oral consumption of cranberry juice cocktail inhibits molecular-scale adhesion of clinical uropathogenic Escherichia coli. J Med Food 14:739–745

LaPlante KL, Sarkisian SA, Woodmansee S, Rowley DC, Seeram NP (2012) Effects of cranberry extracts on growth and biofilm production of Escherichia coli and Staphylococcus species. Phytother Res 26:1371–1374

Howell AB, Reed JD, Krueger CG, Winterbottom R, Cunningham DG, Leahy M (2005) A-type cranberry proanthocyanidins and uropathogenic bacterial anti-adhesion activity. Phytochemistry 66:2281–2291

Raditic DM (2015) Complementary and integrative therapies for lower urinary tract diseases. Vet Clin North Am Small Anim Pract 45:857–878

Dason S, Dason JT, Kapoor A (2011) Guidelines for the diagnosis and management of recurrent urinary tract infection in women. Can Urol Assoc J 5:316–322

Davidson E, Zimmermann BF, Jungfer E, Chrubasik-Hausmann S (2014) Prevention of urinary tract infections with Vaccinium products. Phytother Res 28:465–470

Head KA (2008) Natural approaches to prevention and treatment of infections of the lower urinary tract. Altern Med Rev 13:227–244

Mary Anne Roshni Amalaradjou, Venkitanarayanan K (2011) Natural approaches for controlling urinary tract infections. In: Tenke P (ed) Urinary tract infections. InTech, New York, pp 227–244

Geetha RV, Roy A, Lakshmi T (2011) Nature’s weapon against urinary tract infections. Int J Drug Dev Res 3:85–100

Geetha RV, Roy A, Lakshmi T (2012) In vitro evaluation of anti bacterial activity of leaf extract of Agathosma betulina on urinary tract pathogens. Intl J Pharm Sci Rev Res 14:94–97

Rafsanjany N, Lechtenberg M, Petereit F, Hensel A (2013) Antiadhesion as a functional concept for protection against uropathogenic Escherichia coli: In vitro studies with traditionally used plants with antiadhesive activity against uropathogenic Escherichia coli. J Ethnopharmacol 145:591–597

Williams G, Craig JC (2009) Prevention of recurrent urinary tract infection in children. Curr Opin Infect Dis 22:72–76

Mutters NT, Mampel A, Kropidlowski R, Biehler K, Günther F, Bălu I, Malek V, Frank U (2018) Treating urinary tract infections due to MDR E. coli with Isothiocyanates—a phytotherapeutic alternative to antibiotics? Fitoterapia 129:237–240

Drew A (2000) Goldenseal. Curr Ther 41:47–48

Tims M, Batista C (2007) Effects of root isoquinoline alkaloids from Hydrastis canadensis on Fusarium oxysporum isolated from Hydrastis root tissue. J Chem Ecol 33:1449–1455

Genovese C, Davinelli S, Mangano K, Tempera G, Nicolosi D, Corsello S, Vergalito F, Tartaglia E, Scapagnini G, Di Marco R (2018) Effects of a new combination of plant extracts plus d-mannose for the management of uncomplicated recurrent urinary tract infections. J Chemother 30:107–114

Ceyhan N, Keskin D, Uǧur A (2012) Antimicrobial activities of different extracts of eight plant species from four different family against some pathogenic microorganisms. J Food Agric Environ 10:193–197

Das G, Patra JK, Baek KH (2017) Antibacterial properties of endophytic bacteria isolated from a fern species Equisetum arvense L. against foodborne pathogenic bacteria Staphylococcus aureus and Escherichia coli O157:H7. Foodborne Pathog Dis 14:50–58

Asgarpanah J, Roohi E (2012) Phytochemistry and pharmacological properties of Equisetum arvense L. J Med Plants Res 6:3689–3693

Radojevic ID, Stankovic MS, Stefanovic OD, Topuzovic MD, Comic LR, Ostojic AM (2012) Great horsetail (Equisetum telmateia Ehrh.): active substances content and biological effects. EXCLI J 11:59–67

Chrubasik JE, Roufogalis BD, Wagner H, Chrubasik SA (2007) A comprehensive review on nettle effect and efficacy profiles, part I: Herba urticae. Phytomedicine 14:423–435

Kukrić ZZ, Topalić-Trivunović LN, Kukavica BM, Matoš SB, Pavičić SS, Boroja MM, Savić AV (2012) Characterization of antioxidant and antimicrobial activities of nettle leaves (Urtica dioica L.). Acta Periodica Technol 2012:257–272.

Balkhi TMB, Bhat FA (2012) Bioactive potential of leaf extracts from Urtica dioica L. against fish and human pathogenic bacteria. Afr J Microbiol Res 6:6893–6899

Kreft S, Lunder M (2011) Herbal medicinal products for the treatment of the urogenital infection. Farm Vestn 62:87–95

Bahmani M, Saki K, Shahsavari S, Rafieian-Kopaei M, Sepahvand R, Adineh A (2015) Identification of medicinal plants effective in infectious diseases in Urmia, northwest of Iran. Asian Pac J Trop Biomed 5:858–864

Shaaban MT, Ghozlan HA, El Maghraby MM (2012) Susceptibility of bacteria infecting urinary tract to some antibiotics and essential oils. JAPS 2:9

Kwiecińska-Piróg J, Skowron K, Bogiel T, Białucha A, Przekwas J, Gospodarek-Komkowska E (2019) Vitamin C in the presence of sub-Inhibitory concentration of aminoglycosides and fluoroquinolones alters Proteus mirabilis biofilm inhibitory rate. Antibiotics 8:116

Monroy-Torres R, Medina-Jiménez AK (2019) Cranberry juice and other functional foods in urinary tract infections in women: a review of actual evidence and main challenges. Front Clin Drug Res Anti Infect. https://doi.org/10.2174/9781681086378119050007

Yousefichaijan P, Goudarzi AA, Rezagholizamenjany M, Kahbazi M, Rafeie M, Shabestari AA, Shariatmadari F, Taherahmadi H (2018) Efficacy of ascorbic acid supplementation in relief of symptoms due to febrile upper urinary tract infection in children, a clinical trial and hospital based study. Arch Pediatric Infect Dis 6:e57071

Ochoa-Brust GJ, Fernandez AR, Villanueva-Ruiz GJ, Velasco R, Trujillo-Hernandez B, Vasquez C (2007) Daily intake of 100 mg ascorbic acid as urinary tract infection prophylactic agent during pregnancy. Acta Obstet Gynecol Scand 86:783–787

Manzoor MAP, Duwal SR, Mujeeburahiman M, Rekha PD (2018) Vitamin C inhibits crystallization of struvite from artificial urine in the presence of Pseudomonas aeruginosa. Int Braz J Urol 44:1234–1242

Montorsi F, Gandaglia G, Salonia A, Briganti A, Mirone V (2016) Effectiveness of a combination of cranberries, Lactobacillus rhamnosus, and vitamin C for the management of recurrent urinary tract infections in women: results of a pilot study. Eur Urol 70:912–915

Carlsson S, Wiklund NP, Engstrand L, Weitzberg E, Lundberg JON (2001) Effects of pH, nitrite, and ascorbic acid on nonenzymatic nitric oxide generation and bacterial growth in urine. Nitric Oxide Biol Chem 5:580–586

Yoo C, Kim CS (2008) Complementary and alternative medicine in urology. Korean J Urol 49:193–202

Yilmaz A, Bahat E, Yilmaz GG, Hasanoglu A, Akman S, Guven AG (2007) Adjuvant effect of vitamin A on recurrent lower urinary tract infections. Pediatr Int 49:310–313

Kahbazi M, Sharafkhah M, Yousefichaijan P, Taherahmadi H, Rafiei M, Kaviani P, Abaszadeh S, Massoudifar A, Mohammadbeigi A (2019) Vitamin A supplementation is effective for improving the clinical symptoms of urinary tract infections and reducing renal scarring in girls with acute pyelonephritis: a randomized, double-blind placebo-controlled, clinical trial study. Complement Ther Med 42:429–437

Sobouti B, Hooman N, Movahed M (2013) The effect of vitamin e or vitamin A on the prevention of renal scarring in children with acute pyelonephritis. Pediatr Nephrol 28:277–283

Ayazi P, Moshiri SA, Mahyar A, Moradi M (2011) The effect of vitamin A on renal damage following acute pyelonephritis in children. Eur J Pediatr 170:347–350

Smith JM, Cancienne JM, Brockmeier SF, Werner BC (2020) Vitamin D deficiency and total shoulder arthroplasty complications. Shoulder Elbow

Hertting O, Lüthje P, Sullivan D, Aspenström P, Brauner A (2017) Vitamin D-deficient mice have more invasive urinary tract infection. PLoS ONE 12:e0180810

Ramos NL, Sekikubo M, Kironde F, Mirembe F, Sääf M, Brauner A (2015) The impact of vitamin D on the innate immune response to uropathogenic Escherichia coli during pregnancy. Clin Microbiol Infect 21:482.e481-482.e487

Deng QF, Chu H, Wen Z, Cao YS (2019) Vitamin D and urinary tract infection: a systematic review and meta-analysis. Ann Clin Lab Sci 49:134–142

Handoka NM, Amin RE, Shalaby SA (2018) Vitamin D deficiency is associated with urinary tract infection in children. Arch Med Sci 14:115–121

Tekin M, Konca C, Celik V, Almis H, Kahramaner Z, Erdemir A, Gulyuz A, Uckardes F, Turgut M (2015) The association between Vitamin D levels and urinary tract infection in children. Horm Res Paediatr 83:198–203

Haghdoost S, Pazandeh F, Darvish S, Khabazkhoob M, Huss R, Lak TB (2019) Association of serum vitamin D levels and urinary tract infection in pregnant women: a case control study. Eur J Obstet Gynecol Reprod Biol 243:51–56

Georgieva V, Kamolvit W, Herthelius M, Lüthje P, Brauner A, Chromek M (2019) Association between vitamin D, antimicrobial peptides and urinary tract infection in infants and young children. Acta Paediatr Int J Paediatr 108:551–556

Jorde R, Sollid ST, Svartberg J, Joakimsen RM, Grimnes G, Hutchinson MYS (2016) Prevention of urinary tract infections with vitamin D supplementation 20,000 IU per week for five years. Results from an RCT including 511 subjects. Infect Dis 48:823–828

Hemila H, Chalker E (2015) The effectiveness of high dose zinc acetate lozenges on various common cold symptoms: a meta-analysis. BMC Fam Pract 16:24

Consolo LZZ, Melnikov P, Cônsolo FZ, Nascimento VA, Pontes JCDV (2013) Zinc supplementation in children and adolescents with acute leukemia. Eur J Clin Nutr 67:1056–1059

Haider BA, Lassi ZS, Ahmed A, Bhutta ZA (2011) Zinc supplementation as an adjunct to antibiotics in the treatment of pneumonia in children 2 to 59 months of age. Cochrane Datab Syst Rev 1:1

Chohan ZH, Arif M, Shafiq Z, Yaqub M, Supuran CT (2006) In vitro antibacterial, antifungal and cytotoxic activity of some isonicotinoylhydrazide Schiff’s bases and their cobalt(II), copper(II), nickel(II) and zinc(II) complexes. J Enzyme Inhib Med Chem 21:95–103

Dizdar OS, Baspınar O, Kocer D, Dursun ZB, Avcı D, Karakükcü C, Çelik I, Gundogan K (2016) Nutritional risk, micronutrient status and clinical outcomes: a prospective observational study in an infectious disease clinic. Nutrients 8:1

Hamer DH, Sempértegui F, Estrella B, Tucker KL, Rodríguez A, Egas J, Dallal GE, Selhub J, Griffiths JK, Meydani SN (2009) Micronutrient deficiencies are associated with impaired immune response and higher burden of respiratory infections in elderly Ecuadorians. J Nutr 139:113–119

Mohsenpour B, Ahmadi A, Baneh AM, Hajibagheri K, Ghaderi E, Afrasiabian S, Azizi S (2019) Relation between serum zinc levels and recurrent urinary tract infections in female patients: a case–control study. Med J Islam Repub Iran 33:199–201

Nia SJ, Noorbakhsh S, Izadi A, Pour FS, Tabatabaei A, Shokrollahi MR (2013) Comparison of vitamin A, D & zinc serum levels between children with urinary tract infection and control group in two University Hospital. Tehran Uni Med J 71:244–249

Narayanan A, Nair MS, Muyyarikkandy MS, Amalaradjou MA (2018) Inhibition and inactivation of uropathogenic Escherichia coli Biofilms on urinary catheters by Sodium Selenite. Int J Mol Sci 19:1

Deutch CE, Spahija I, Wagner CE (2014) Susceptibility of Escherichia coli to the toxic L-proline analogue L-selenaproline is dependent on two L-cystine transport systems. J Appl Microbiol 117:1487–1499

Hafez AS, Fahim HI, Wafaay H, Mohamed FA (1993) A comparative study of blood retinol and selenium in minor lower urinary lesions. A case control study. J Egypt Public Health Assoc 68:247–263

Hyre AN, Kavanagh K, Kock ND, Donati GL, Subashchandrabose S (2017) Copper is a host effector mobilized to urine during urinary tract infection to impair bacterial colonization. Infect Immun 85:1

Subashchandrabose S, Mobley HLT (2015) Back to the metal age: battle for metals at the host-pathogen interface during urinary tract infection. Metallomics 7:935–942

Subashchandrabose S, Hazen TH, Brumbaugh AR, Himpsl SD, Smith SN, Ernst RD, Rasko DA, Mobley HLT (2014) Host-specific induction of Escherichia coli fitness genes during human urinary tract infection. Proc Natl Acad Sci USA 111:18327–18332

Spooner JB (1984) Alkalinisation in the management of cystitis. J Int Med Res 12:30–34

Strassner C, Friesen A (1995) Therapy of candiduria by alkalinization of urine. Oral treatment with potassium-sodium-hydrogen citrate. Fortschr Med 113:359–362

Firon N, Ashkenazi S, Mirelman D, Ofek I, Sharon N (1987) Aromatic alpha-glycosides of mannose are powerful inhibitors of the adherence of type 1 fimbriated Escherichia coli to yeast and intestinal epithelial cells. Infect Immun 55:472–476

Schaeffer AJ (2003) Structural basis of tropism of Escherichia coli to the bladder during urinary tract infection. J Urol 170:335

Scribano D, Sarshar M, Prezioso C, Lucarelli M, Angeloni A, Zagaglia C, Palamara AT, Ambrosi C (2020) D-Mannose treatment neither affects uropathogenic Escherichia coli properties nor induces stable fimh modifications. Molecules 25:1

Kuzmenko AV, Kuzmenko VV, Gyaurgiev TA (2019) Efficacy of combined antibacterial-prebiotic therapy in combination with d-mannose in women with uncomplicated lower urinary tract infection. Urologiia 2019:38–43

Duncan D (2019) Alternative to antibiotics for managing asymptomatic and non-symptomatic bacteriuria in older persons: a review. Brit J Community Nurs 24:116–119

Wellens A, Garofalo C, Nguyen H, Van Gerven N, Slattegard R, Hernalsteens JP, Wyns L, Oscarson S, De Greve H, Hultgren S, Bouckaert J (2008) Intervening with urinary tract infections using anti-adhesives based on the crystal structure of the FimH-oligomannose-3 complex. PLoS ONE 3:e2040

Schaeffer AJ, Chmiel JS, Duncan JL, Falkowski WS (1984) Mannose-sensitive adherence of Escherichia coli to epithelial cells from women with recurrent urinary tract infections. J Urol 131:906–910

Russo E, Montt Guevara M, Giannini A, Mannella P, Palla G, Caretto M, Pancetti F, Genazzani AD, Simoncini T (2020) Cranberry, D-mannose and anti-inflammatory agents prevent lower urinary tract symptoms in women undergoing prolapse surgery. Climacteric 23:201–205

Marcon J, Schubert S, Stief CG, Magistro G (2019) In vitro efficacy of phytotherapeutics suggested for prevention and therapy of urinary tract infections. Infection 47:937–944

Klein T, Abgottspon D, Wittwer M, Rabbani S, Herold J, Jiang X, Kleeb S, Luthi C, Scharenberg M, Bezencon J, Gubler E, Pang L, Smiesko M, Cutting B, Schwardt O, Ernst B (2010) FimH antagonists for the oral treatment of urinary tract infections: from design and synthesis to in vitro and in vivo evaluation. J Med Chem 53:8627–8641

Gorbach SL (2002) Probiotics in the third millennium. Dig Liver Dis 34(Suppl 2):S2-7

Amdekar S, Singh V, Singh DD (2011) Probiotic therapy: immunomodulating approach toward urinary tract infection. Curr Microbiol 63:484–490

Marteau P, Boutron-Ruault MC (2002) Nutritional advantages of probiotics and prebiotics. Br J Nutr 87(Suppl 2):S153-157

Prasetyo RV, Surono I, Soemyarso NA, Djojodimedjo T, Rauf S, Noer MS, Sudarmo SM (2020) Lactobacillus plantarum IS-10506 promotes renal tubular regeneration in pyelonephritic rats. Benef Microbes 11:59–66

Reid G, Bruce AW (2006) Probiotics to prevent urinary tract infections: the rationale and evidence. World J Urol 24:28–32

Petraitytė S, Šipailienė A (2019) Enhancing encapsulation efficiency of alginate capsules containing lactic acid bacteria by using different divalent cross-linkers sources. LWT 110:307–315

Aroutcheva A, Gariti D, Simon M, Shott S, Faro J, Simoes JA, Gurguis A, Faro S (2001) Defense factors of vaginal lactobacilli. Am J Obstet Gynecol 185:375–379

Mastromarino P, Brigidi P, Macchia S, Maggi L, Pirovano F, Trinchieri V, Conte U, Matteuzzi D (2002) Characterization and selection of vaginal Lactobacillus strains for the preparation of vaginal tablets. J Appl Microbiol 93:884–893

Hudson PL, Hung KJ, Bergerat A, Mitchell C (2020) Effect of vaginal Lactobacillus species on Escherichia coli growth. Female Pelvic Med Reconstr Surg 26:146–151

Wolff BJ, Price TK, Joyce CJ, Wolfe AJ, Mueller ER (2019) Oral probiotics and the female urinary microbiome: a double-blinded randomized placebo-controlled trial. Int Urol Nephrol 51:2149–2159

Vasiee A, Mortazavi SA, Sankian M, Yazdi FT, Mahmoudi M, Shahidi F (2019) Antagonistic activity of recombinant Lactococcus lactis NZ1330 on the adhesion properties of Escherichia coli causing urinary tract infection. Microb Pathog 133:103547

Falah F, Vasiee A, Behbahani BA, Yazdi FT, Moradi S, Mortazavi SA, Roshanak S (2019) Evaluation of adherence and anti-infective properties of probiotic Lactobacillus fermentum strain 4–17 against Escherichia coli causing urinary tract infection in humans. Microb Pathog 131:246–253

Osset J, Bartolome RM, Garcia E, Andreu A (2001) Assessment of the capacity of Lactobacillus to inhibit the growth of uropathogens and block their adhesion to vaginal epithelial cells. J Infect Dis 183:485–491

Hutt P, Shchepetova J, Loivukene K, Kullisaar T, Mikelsaar M (2006) Antagonistic activity of probiotic lactobacilli and bifidobacteria against entero- and uropathogens. J Appl Microbiol 100:1324–1332

Mezzasalma V, Manfrini E, Ferri E, Boccarusso M, Di Gennaro P, Schiano I, Michelotti A, Labra M (2017) Orally administered multispecies probiotic formulations to prevent uro-genital infections: a randomized placebo-controlled pilot study. Arch Gynecol Obstet 295:163–172

Leccese Terraf MC, Juarez Tomás MS, Rault L, Le Loir Y, Even S, Nader-Macías MEF (2017) In vitro effect of vaginal lactobacilli on the growth and adhesion abilities of uropathogenic Escherichia coli. Arch Microbiol 199:767–774

Reid G, Bruce AW, Taylor M (1992) Influence of three-day antimicrobial therapy and Lactobacillus vaginal suppositories on recurrence of urinary tract infections. Clin Ther 14:11–16