Decreased transport of leptin across the blood–brain barrier in rats lacking the short form of the leptin receptor☆

Banks, 1999, Impaired transport of leptin across the blood-brain barrier in obesity, Peptides, 20, 1341, 10.1016/S0196-9781(99)00139-4 Banks WA, Kastin AJ. Measurement of transport of cytokines across the blood-brain barrier. In: Conn PM, De Souza EB, editors. Neurobiology of cytokines, Part A. San Diego: Academic Press, Inc., 1993. pp. 67–77. Banks, 1996, Leptin enters the brain by a saturable system independent of insulin, Peptides, 17, 305, 10.1016/0196-9781(96)00025-3 Bjorbaek, 1998, Expression of leptin receptor isoforms in rat brain microvessels, Endocrinology, 139, 3485, 10.1210/en.139.8.3485 Caro, 1996, Decreased cerebrospinal-fluid/serum leptin ratio in obesity, Lancet, 348, 159, 10.1016/S0140-6736(96)03173-X Elmquist, 1998, Unraveling the central nervous system pathways underlying responses to leptin, Nature Neurosci, 1, 445, 10.1038/2164 Halaas, 1997, Physiological response to long-term peripheral and central leptin infusion in lean and obese mice, Proc Natl Acad Sci USA, 94, 8878, 10.1073/pnas.94.16.8878 Kastin AJ, Pan W, Maness LM, Banks WA. Peptides crossing the blood-brain barrier: some unusual observations. Brain Res 1999; in press. Koistinen, 1998, Circulating Leptin has saturable transport into intrathecal space in humans, Eur J Clin Invest, 28, 894, 10.1046/j.1365-2362.1998.00386.x Lee, 1996, Abnormal splicing of the leptin receptor in diabetic mice, Nature, 379, 632, 10.1038/379632a0 Maness, 1998, Fate of leptin after intracerebroventricular injection into the mouse brain, Endocrinology, 139, 4556, 10.1210/en.139.11.4556 Maresh, 1999, Peptide transport system 1 (PTS-1) for Tyr-MIF-1 and Met-enkephalin differs from the receptors for either, Brain Res, 839, 336, 10.1016/S0006-8993(99)01755-2 Pan, 1999, Entry of EGF into brain is rapid and saturable, Peptides, 20, 1091, 10.1016/S0196-9781(99)00094-7 Pan W, Vallance KL, Kastin AJ. TGF alpha crossing from blood to brain is trapped by capillary endothelium. Exp Neurol 1999; in press. Ramsey, 1998, Different central and peripheral responses to leptin in rhesus monkeys, J Clin Endocrinol Metab, 83, 3230, 10.1210/jc.83.9.3230 Schwartz, 1996, Cerebrospinal fluid leptin levels, Nature Med, 2, 589, 10.1038/nm0596-589 Steiner, 1996, Editorial. Lords and ladies leapin’ on leptin, Endocrinology, 137, 4533, 10.1210/en.137.11.4533 Takaya, 1996, Nonsense mutation of leptin receptor in the obese spontaneously hypertensive Koletsky rat, Nature Genet, 14, 130, 10.1038/ng1096-130 Van Heek, 1997, Diet-induced obese mice develop peripheral, but not central, resistance to leptin, J Clin Invest, 99, 385, 10.1172/JCI119171 Wu–Peng, 1997, Phenotype of obese Koletsky (f) rat due to Tyr763 stop mutation in the extracellular domain of the leptin receptor (lepr), Diabetes, 46, 513, 10.2337/diabetes.46.3.513