Decreased serum cell-free DNA levels in rheumatoid arthritis

Marina Dunaeva1, Bastiaan C. Buddingh1, René E. M. Toes2, Jolanda J. Luime3, Erik Lubberts3, Ger J.M. Pruijn1
1284 Department of Biomolecular Chemistry, Institute for Molecules and Materials and Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands
2Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands
3Department of Rheumatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

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van Venrooij WJ, van Beers J, Pruijn GJ (2011) Anti-CCP antibodies: the past, the present and the future. Nat Rev Rheumatol 7:391–398

Steiner G (2007) Auto-antibodies and autoreactive T-cells in rheumatoid arthritis: pathogenetic players and diagnostic tools. Clin Rev Allergy Immunol 32:23–36

Niienhuis S, Zendman A, Vossenaar E, Pruijn G, van Venrooij W (2004) Autoantibodies to citrullinated proteins in rheumatoid arthritis: clinical performance and biochemical aspects of an RA-specific marker. Clin Chim Acta 350:17–34

Landewe R (2003) The benefits of early treatment in rheumatoid arthritis: confounding by indication, and the issue of timing. Arthritis Rheum 48:1–5

Gauthier V, Tyler L, Mannik M (1996) Blood clearance kinetics and liver uptake of mononucleosomes in mice. J Immunol 156:1151–1156

Lo Y, Zhang J, Leung T, Lau T, Chang AM, Hjelm NM (1999) Rapid clearance of fetal DNA from maternal plasma. Am J Hum Genet 64:218–224

Rainer T, Wong L, Lam W, Yuen E, Lam NY, Metreweli C et al (2003) Prognostic use of circulating plasma nucleic acid concentrations in patients with acute stroke. Clin Chem 49:562–569

Geiger S, Holdenrieder S, Stieber P, Hamann GF, Bruening R, Ma J et al (2006) Nucleosomes in serum of patients with early cerebral stroke. Cerebrovasc Dis 21:32–37

Chang C, Chia R, Wu T, Tsao K, Sun C, Wu J (2003) Elevated cell-free serum DNA detected in patients with myocardial infarction. Clin Chim Acta 327:95–101

Rhodes A, Wort S, Thomas H, Collinson P, Bennett E (2006) Plasma DNA concentration as a predictor of mortality and sepsis in critically ill patients. Crit Care 10:R60

Gornik I, Wagner J, Gasparović V, Lauc G, Gornik O (2009) Free serum DNA is an early predictor of severity in acute pancreatitis. Clin Biochem 42:38–43

Schwarzenbach H, Hoon D, Pantel K (2011) Cell-free nucleic acids as biomarkers in cancer patients. Nat Rev Cancer 11:426–437

Dawson S, Tsui D, Murtaza M, Biggs H, Rueda OM, Chin SF et al (2013) Analysis of circulating tumor DNA to monitor metastatic breast cancer. N Engl J Med 368:1199–1209

Perkins G, Yap T, Pope L, Cassidy AM, Dukes JP, Riisnaes R et al (2012) Multi-purpose utility of circulating plasma DNA testing in patients with advanced cancers. PLoS One 7:e47020

Galeazzi M, Morozzi G, Piccini M, Chen J, Bellisai F, Fineschi S et al (2003) Dosage and characterization of circulating DNA: present usage and possible applications in systemic autoimmune disorders. Autoimmun Rev 2:50–55

Bartoloni E, Ludovini V, Alunno A, Pistola L, Bistoni O, Crino L et al (2011) Increased levels of circulating DNA in patients with systemic autoimmune diseases: a possible marker of disease activity in Sjögren’s syndrome. Lupus 20:928–935

Zhong X, von Mühlenen I, Li Y, Kang A, Gupta AK, Tyndall A et al (2007) Increased concentrations of antibody-bound circulatory cell-free DNA in rheumatoid arthritis. Clin Chem 53:1609–1614

de Rooy D, van der Linden M, Knevel R, Huizinga T, van der Helm-van Mil A (2011) Predicting arthritis outcomes—what can be learned from the Leiden early arthritis clinic? Rheumatology 50:93–100

Umetani N, Kim J, Hiramatsu S, Reber H, Hines O, Bilchik A (2006) Increased integrity of free circulating DNA in sera of patients with colorectal or periampullary cancer: direct quantitative PCR for ALU repeats. Clin Chem 52:1062–1069

Huang Z, Hua D, Hu Y, Cheng Z, Zhou X, Xie Q et al (2012) Quantitation of plasma circulating DNA using quantitative PCR for the detection of hepatocellular carcinoma. Pathol Oncol Res 18:271–276

Chitrabamrung S, Bannett J, Rubin R, Tan E (1981) A radial diffusion assay for plasma and serum deoxyribonuclease I. Rheumatol Int 1:49–53

Ohmura K, Terao C, Maruya E, Katayama M, Matoba K, Shimada K et al (2010) Anti-citrullinated peptide antibody-negative RA is a genetically distinct subset: a definitive study using only bone-erosive ACPA-negative rheumatoid arthritis. Rheumatology 49:2298–2304

Seegobin S, Ma M, Dahanayake C, Cope AP, Scott DL, Lewis CM et al (2014) ACPA-positive and ACPA-negative rheumatoid arthritis differ in their requirements for combination DMARDs and corticosteroids: secondary analysis of a randomized controlled trial. Arthritis Res Ther 16:R13

Shakhmaeva I, Saifullina D, Sattarova L, Abdullin T (2011) Electrochemical sensor for blood deoxyribonucleases: design and application to the diagnosis of autoimmune thyroiditis. Anal Bioanal Chem 401:2591–2597

Napirei M, Ricken A, Eulitz D, Knoop H, Mannherz H (2004) Expression pattern of the deoxyribonuclease 1 gene: lessons from the Dnase1 knockout mouse. Biochem J 380:929–937

Jørgensen M, Rekvig O, Jacobsen R, Jacobsen S, Fenton K (2011) Circulating levels of chromatin fragments are inversely correlated with anti-dsDNA antibody levels in human and murine systemic lupus erythematosus. Immunol Lett 138:179–186

D’Auria F, Rovere-Querini P, Giazzon M, Ajello P, Baldissera E, Manfredi AA et al (2004) Accumulation of plasma nucleosomes upon treatment with anti-tumour necrosis factor-alpha antibodies. J Intern Med 255:409–418

Leon S, Ehrlich G, Shapiro B, Labbate V (1977) Free DNA in the serum of rheumatoid arthritis patients. J Rheumatol 4:139–143

Sjoholm M, Hoffmann G, Lindgren S, Dillner J, Carlson J (2005) Comparison of archival plasma and formalin-fixed paraffin-embedded tissue for genotyping in hepatocellular carcinoma. Cancer Epidemiol Biomark Prev 14:251–255

Beck J, Urnovitz HB, Riggert J, Clerici M, Schütz E (2009) Profile of the circulating DNA in apparently healthy individuals. Clin Chem 55:730–738

Stroun M, Lyautey J, Lederrey C, Mulcahy HE, Anker P (2001) Alu repeat sequences are present in increased proportions compared to a unique gene in plasma/serum DNA: evidence for a preferential release from viable cells? Ann N Y Acad Sci 945:258–264

Lui Y, Chik K, Chiu R, Ho C, Lam C, Lo Y (2002) Predominant hematopoietic origin of cell-free DNA in plasma and serum after sex-mismatched bone marrow transplantation. Clin Chem 48:421–427

Smoleńska Z, Kaznowska Z, Zarówny D, Simmonds HA, Smoleński R (1999) Effect of methotrexate on blood purine and pyrimidine levels in patients with rheumatoid arthritis. Rheumatology 38:997–1002

Hyrich K, Silman A, Watson K, Symmons D (2004) Anti-tumour necrosis factor alpha therapy in rheumatoid arthritis: an update on safety. Ann Rheum Dis 63:1538–1543

Hitchon C, El-Gabalawy H (2004) Oxidation in rheumatoid arthritis. Arthritis Res Ther 6:265–728

Szodoray P, Jellestad S, Nakken B, Jg Brun, Jonsson R (2003) Programmed cell death in rheumatoid arthritis peripheral blood T-cell subpopulations determined by laser scanning cytometry. Lab Invest 83:1839–1848

Smith M, Weedon H, Papangelis V, Walker J, Roberts-Thomson P, Ahern M (2010) Apoptosis in the rheumatoid arthritis synovial membrane: modulation by disease-modifying anti-rheumatic drug treatment. Rheumatology 49:862–875