Decreased number of parvalbumin and cholinergic interneurons in the striatum of individuals with Tourette syndrome

Journal of Comparative Neurology - Tập 518 Số 3 - Trang 277-291 - 2010
Yuko Kataoka1, Paul Kalanithi1, Heidi Grantz1, Michael L. Schwartz2, Clifford B. Saper3, James F. Leckman1, Flora M. Vaccarino1,2
1Child Study Center, Yale University, New Haven, Connecticut 06520
2Department of Neurobiology, Yale University, New Haven, Connecticut 06520
3Department of Neurology & Neuroscience, Harvard Medical School, Boston, Massachusetts 02215

Tóm tắt

AbstractCorticobasal ganglia neuronal ensembles bring automatic motor skills into voluntary control and integrate them into ongoing motor behavior. A 5% decrease in caudate (Cd) nucleus volume is the most consistent structural finding in the brain of patients with Tourette syndrome (TS), but the cellular abnormalities that underlie this decrease in volume are unclear. In this study the density of different types of interneurons and medium spiny neurons (MSNs) in the striatum was assessed in the postmortem brains of 5 TS subjects as compared with normal controls (NC) by unbiased stereological analyses. TS patients demonstrated a 50%–60% decrease of both parvalbumin (PV)+ and choline acetyltransferase (ChAT)+ cholinergic interneurons in the Cd and the putamen (Pt). Cholinergic interneurons were decreased in TS patients in the associative and sensorimotor regions but not in the limbic regions of the striatum, such that the normal gradient in density of cholinergic cells (highest in associative regions, intermediate in sensorimotor and lowest in limbic regions) was abolished. No significant difference was present in the densities of medium‐sized calretinin (CR)+ interneurons, MSNs, and total neurons. The selective deficit of PV+ and cholinergic striatal interneurons in TS subjects may result in an impaired cortico/thalamic control of striatal neuron firing in TS. J. Comp. Neurol. 518:277–291, 2010. © 2009 Wiley‐Liss, Inc.

Từ khóa


Tài liệu tham khảo

10.1016/0166-2236(95)80020-3

10.1212/01.WNL.0000076181.39162.FC

10.1523/JNEUROSCI.14-06-03969.1994

10.1002/mds.21398

10.1016/j.neuron.2004.08.035

10.1371/journal.pone.0001174

10.1007/s00702-007-0803-8

10.1212/01.wnl.0000180957.98702.69

10.1002/(SICI)1098-2396(199811)30:3<284::AID-SYN6>3.0.CO;2-7

10.1002/cne.902550208

10.1002/jemt.1060100304

10.1038/sj.npp.1300710

Friedman E, 1983, Chronic fluphenazine and clozapine elicit opposite changes in brain muscarinic receptor binding: implications for understanding tardive dyskinesia, J Pharmacol Exp Ther, 226, 7

Graybiel AM, 2001, The neurobiology of repetitive behaviors: clues to the neurobiology of Tourette syndrome, Adv Neurol, 85, 123

10.1126/science.8091209

10.1002/1098-2396(20010101)39:1<51::AID-SYN7>3.0.CO;2-Z

10.1111/j.1699-0463.1988.tb00954.x

10.1016/j.tins.2004.06.003

10.1111/j.1749-6632.1999.tb09259.x

10.1523/JNEUROSCI.1196-05.2005

10.1016/S0165-0173(99)00039-9

10.1002/(SICI)1096-9861(19970721)384:1<1::AID-CNE1>3.0.CO;2-5

10.1016/S0306-4522(99)00279-1

10.1016/j.biopsych.2005.04.007

10.1016/0304-3940(94)90537-1

10.1073/pnas.0502624102

10.1523/JNEUROSCI.13-11-04908.1993

10.1016/0006-8993(90)90002-S

10.1016/j.biopsych.2007.08.018

10.1523/JNEUROSCI.22-02-00529.2002

10.1016/S0140-6736(02)11526-1

10.1001/archpsyc.1982.04290080001001

10.1097/00004583-198907000-00015

10.1111/j.1469-7610.2006.01620.x

10.1073/pnas.96.26.15222

10.1016/j.tins.2005.04.006

Lohr JB, 2000, Neuroleptic‐induced striatal damage in rats: a study of antioxidant treatment using accelerometric and immunocytochemical methods, Psychopharmacology (Berl), 148, 171, 10.1007/s002130050039

10.1016/0006-3223(88)90275-2

10.1001/archpsyc.61.12.1259

10.1523/JNEUROSCI.20-10-03798.2000

10.1002/1096-9861(20000108)429:2<321::AID-CNE11>3.0.CO;2-A

10.1007/BF02439593

10.1002/cne.10096

10.1016/0024-3205(82)90431-3

10.1523/JNEUROSCI.3709-06.2007

10.1016/0165-0173(94)00007-C

10.1002/cne.20330

10.1111/j.1471-4159.1980.tb03698.x

10.1001/archpsyc.55.4.326

10.1001/archpsyc.60.4.415

10.1046/j.1460-9568.1998.00246.x

10.1212/WNL.53.9.2108

Rupniak NM, 1986, Differential alterations in striatal acetylcholine function in rats during 12 months' continuous administration of haloperidol, sulpiride, or clozapine, Clin Neuropharmacol, 9, 282, 10.1097/00002826-198606000-00006

10.1016/0143-4160(93)90089-O

10.1136/jnnp.2006.104067

10.1176/appi.ajp.159.8.1329

10.1002/mds.10649

10.1038/sj.npp.1300039

10.1016/j.neuroscience.2007.03.003

10.1016/0197-4580(93)90112-O

10.1002/cne.21819

10.1016/j.jns.2007.01.069

Thông tin
Thông tin xuất bản

Journal of Comparative Neurology

Tập 518 Số 3

277-291

Thông tin tác giả