Decreased alternative splicing of estrogen receptor-α mRNA in the Alzheimer's disease brain

Anandappa, 2000, Variant estrogen receptor α mRNAs in human breast cancer specimens, Int. J. Cancer, 88, 209, 10.1002/1097-0215(20001015)88:2<209::AID-IJC10>3.0.CO;2-M Andersen, 1999, Gender differences in the incidence of AD and vascular dementia: The EURODEM Studies, Neurology, 53, 1992, 10.1212/WNL.53.9.1992 Bollig, 2000, An estrogen receptor-α splicing variant mediates both positive and negative effects on gene transcription, Mol. Endocrinol, 14, 634 Braak, 1991, Neuropathological staging of Alzheimer-related changes, Acta Neuropathol., 82, 239, 10.1007/BF00308809 Brandi, 1999, Association of the estrogen receptor alpha gene polymorphisms with sporadic Alzheimer's disease, Biochem. Biophys. Res. Commun, 265, 335, 10.1006/bbrc.1999.1665 Brinton, 2005, Investigative models for determining hormone therapy-induced outcomes in brain: evidence in support of a healthy cell bias of estrogen action, Ann. N. Y. Acad. Sci, 1052, 57, 10.1196/annals.1347.005 Chaidarun, 1997, Tumor-specific expression of alternatively spliced estrogen receptor messenger ribonucleic acid variants in human pituitary adenomas, J. Clin. Endocrinol. Metab, 82, 1058 Conrad, 2007, Single molecule profiling of tau gene expression in Alzheimer's disease, J. Neurochem, 103, 1228, 10.1111/j.1471-4159.2007.04857.x Corbo, 2006, Association of estrogen receptor alpha (ESR1) PvuII and XbaI polymorphisms with sporadic Alzheimer's disease and their effect on apolipoprotein E concentration, Dement. Geriatr. Cogn. Disord, 22, 67, 10.1159/000093315 Craig, 2009, Alzheimer's disease in women, Best Pract. Res. Clin. Obstet. Gynaecol, 23, 53, 10.1016/j.bpobgyn.2008.10.004 Daffada, 1995, Tissue-dependent expression of a novel splice variant of the human oestrogen receptor, J. Steroid Biochem. Mol. Biol, 55, 413, 10.1016/0960-0760(95)00217-0 Erenburg, 1997, Loss of an estrogen receptor isoform (ER alpha delta 3) in breast cancer and the consequences of its reexpression: interference with estrogen-stimulated properties of malignant transformation, Mol. Endocrinol, 11, 2,004 Ewing, 1998, Base-calling of automated sequencer traces using phred, Genome Res, 8, 175, 10.1101/gr.8.3.175 Fasco, 2002, Gender-dependent expression of alpha and beta estrogen receptors in human nontumor and tumor lung tissue, Mol. Cell. Endocrinol, 188, 125, 10.1016/S0303-7207(01)00750-X Ferro, 2003, Alternative splicing of the human estrogen receptor α primary transcript: mechanisms of exon skipping, Int. J. Mol. Med, 12, 355 Fleige, 2006, RNA integrity and the effect on the real-time qRT-PCR performance, Mol. Aspects Med, 27, 126, 10.1016/j.mam.2005.12.003 García-Pedrero, 2003, The naturally occurring variant of estrogen receptor (ER) ERΔe7 suppresses estrogen-dependent transcriptional activation by both wild type ERα and ERβ, Endocrinology, 144, 2967, 10.1210/en.2002-0027 Garcia-Segura, 2009, Steroids and neuroprotection: new advances, Front. Neuroendocrinol., 30, v, 10.1016/j.yfrne.2009.04.006 Genazzani, 2007, Estrogen, cognition and female aging, Hum. Reprod. Update, 13, 175, 10.1093/humupd/dml042 Glatz, 2006, The alternative splicing of tau exon 10 and its regulatory proteins CLK2 and TRA2-BETA1 changes in sporadic Alzheimer's disease, J. Neurochem., 96, 635, 10.1111/j.1471-4159.2005.03552.x Greene, 1986, Sequence and expression of human estrogen receptor complementary DNA, Science, 231, 1150, 10.1126/science.3753802 Heinzen, 2007, Alternative ion channel splicing in mesial temporal lobe epilepsy and Alzheimer's disease, Genome Biol, 8, R32, 10.1186/gb-2007-8-3-r32 Hogervorst, 2009, Hormone replacement therapy to maintain cognitive function in women with dementia, Cochrane Database Syst. Rev, 21, 10.1002/14651858.CD003799.pub2 Hope, 2003, Alzheimer's associated variant ubiquitin causes inhibition of the 26S proteasome and chaperone expression, J. Neurochem, 86, 394, 10.1046/j.1471-4159.2003.01844.x Horvath, 2002, Function of the exon 7 deletion variant estrogen receptor α protein in an estradiol-resistant, tamoxifen-sensitive human endometrial adenocarcinoma grown in nude mice, Gynecol. Oncol, 84, 271, 10.1006/gyno.2001.6509 Hu, 1996, Expression of estrogen receptor variants in normal and neoplastic human uterus, Mol. Cell. Endocrinol, 118, 173, 10.1016/0303-7207(96)03780-X Ishunina, 2007, Estrogen receptor α and its splice variants in the hippocampus in aging and Alzheimer's disease, Neurobiol. Aging, 28, 1670, 10.1016/j.neurobiolaging.2006.07.024 Ishunina, 2007, Estrogen receptor α in the hypothalamus and basal forebrain of Alzheimer's disease and vascular dementia cases, Morphological Newsletter, 1–2, 62 Ishunina, 2005, Estrogen receptor-alpha splice variants in the medial mamillary nucleus of Alzheimer's disease patients: identification of a novel MB1 isoform, J. Clin. Endocrinol. Metab, 90, 3757, 10.1210/jc.2004-1858 Ishunina, 2008, Age-dependent ERα MB1 splice variant expression in discrete areas of the human brain, Neurobiol. Aging, 29, 1177, 10.1016/j.neurobiolaging.2007.02.018 Ishunina, 2009, Hippocampal estrogen receptor-alpha splice variant TADDI in the human brain in aging and Alzheimer's disease, Neuroendocrinology, 89, 187, 10.1159/000158573 Ji, 2000, Estrogen receptor gene polymorphism in patients with Alzheimer's disease, vascular dementia and alcohol-associated dementia, Dement. Geriatr. Cogn. Disord, 11, 119, 10.1159/000017224 Kassi, 2001, Molecular analysis of estrogen receptor alpha and beta in lupus patients, Eur. J. Clin. Invest, 31, 86, 10.1046/j.1365-2362.2001.00762.x Kazama, 2004, Association of estrogen receptor alpha gene polymorphisms with neurofibrillary tangles, Dement. Geriatr. Cogn. Disord, 18, 145, 10.1159/000079194 Lambert, 2001, Are the estrogen receptors involved in Alzheimer's disease?, Neurosci. Lett., 306, 193, 10.1016/S0304-3940(01)01806-7 Leygue, 1996, Prevalence of estrogen receptor variant messenger RNAs in human breast cancer, Cancer Res., 56, 4324 Leygue, 1996, Estrogen receptor variants in normal human mammary tissue, J. Natl. Cancer Inst, 88, 284, 10.1093/jnci/88.5.284 Maracchioni, 2007, Mitochondrial damage modulates alternative splicing in neuronal cells: implications for neurodegeneration, J. Neurochem, 100, 142, 10.1111/j.1471-4159.2006.04204.x Mattila, 2000, Interaction between estrogen receptor 1 and the epsilon4 allele of apolipoprotein E increases the risk of familial Alzheimer's disease in women, Neurosci. Lett., 282, 45, 10.1016/S0304-3940(00)00849-1 McKhann, 1984, Clinical diagnosis of Alzheimer's disease: Report of NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Service Task Force on Alzheimer's Disease, Neurology, 34, 939, 10.1212/WNL.34.7.939 Murphy, 1996, Novel mutations in the estrogen receptor messenger RNA in human breast cancers, J. Clin. Endocrinol. Metab, 81, 1420 Naftolin, 2007, Estrogen, estrogen treatment and the post-reproductive woman's brain, Maturitas, 57, 23, 10.1016/j.maturitas.2007.02.005 Nagy, 1998, A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance, Trends Biochem. Sci, 23, 198, 10.1016/S0968-0004(98)01208-0 Perlman, 2005, Expression of estrogen receptor alpha exon-deleted mRNA variants in the human and non-human primate frontal cortex, Neuroscience, 134, 81, 10.1016/j.neuroscience.2005.03.055 Ponglikitmongkol, 1988, Genomic organization of the human oestrogen receptor gene, EMBO J, 7, 3385, 10.1002/j.1460-2075.1988.tb03211.x Poola, 2001, Expression of alternatively spliced estrogen receptor alpha mRNAs is increased in breast cancer tissues, J. Steroid Biochem. Mol. Biol, 78, 459, 10.1016/S0960-0760(01)00118-2 Porrello, 2006, Estrogen receptor alpha and APOEepsilon4 polymorphisms interact to increase risk for sporadic AD in Italian females, Eur. J. Neurol, 13, 639, 10.1111/j.1468-1331.2006.01333.x Reisberg, 1982, The Global Detelioration Scale for assessment of primary degenerative dementia, Am. J. Psychiatry, 139, 1136, 10.1176/ajp.139.9.1136 Rice, 1997, Estrogen receptor mRNA splice variants in pre- and postmenopausal human endometrium and endometrial carcinoma, Gynecol. Oncol, 65, 149, 10.1006/gyno.1997.4623 Taylor, 2010, Oestrogen receptor splice variants in the pathogenesis of disease, Cancer Lett., 288, 133, 10.1016/j.canlet.2009.06.017 van Dijk, 2000, Differences in estrogen receptor α variant messenger RNAs between normal human breast tissue and primary breast carcinomas, Cancer Res., 60, 530 Weickert, 2008, Variants in the estrogen receptor alpha gene and its mRNA contribute to risk for schizophrenia, Hum. Mol. Genet, 17, 2293, 10.1093/hmg/ddn130 Wong, 2009, Transcriptional interaction of an estrogen receptor splice variant and ErbB4 suggests convergence in gene susceptibility pathways in schizophrenia, J. Biol. Chem, 284, 18824, 10.1074/jbc.M109.013243 Yaffe, 2002, Estrogen receptor 1 polymorphism and risk of cognitive impairment in older women, Biol. Psychiatry, 51, 677, 10.1016/S0006-3223(01)01289-6 Zhuang, 1995, Estrogen receptor mutants which do not bind 17 beta-estradiol dimerize and bind to the estrogen response element in vivo, Mol. Endocrinol, 9, 457