Decreased Usage of Specific Scrib Exons Defines a More Malignant Phenotype of Breast Cancer With Worsened Survival

Alldridge, 2008, Proteome profiling of breast tumors by gel electrophoresis and nanoscale electrospray ionization mass spectrometry, J. Proteome Res., 7, 1458, 10.1021/pr7007829 Anastas, 2012, A protein complex of SCRIB, NOS1AP and VANGL1 regulates cell polarity and migration, and is associated with breast cancer progression, Oncogene, 31, 3696, 10.1038/onc.2011.528 Anders, 2012, Detecting differential usage of exons from RNA-seq data, Genome Res., 22, 2008, 10.1101/gr.133744.111 Audebert, 2004, Mammalian Scribble forms a tight complex with the betaPIX exchange factor, Curr. Biol., 14, 987, 10.1016/j.cub.2004.05.051 Beausoleil, 2004, Large-scale characterization of HeLa cell nuclear phosphoproteins, Proc. Natl. Acad. Sci. U. S. A., 101, 12130, 10.1073/pnas.0404720101 Bilder, 2000, Cooperative regulation of cell polarity and growth by drosophila tumor suppressors, Science, 289, 113, 10.1126/science.289.5476.113 Bilder, 2000, Localization of apical epithelial determinants by the basolateral PDZ protein Scribble, Nature, 403, 676, 10.1038/35001108 Cox, 2008, MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification, Nat. Biotechnol., 26, 1367, 10.1038/nbt.1511 Croner, 2014, Quantitative proteome profiling of lymph node-positive vs. -negative colorectal carcinomas pinpoints MX1 as a marker for lymph node metastasis, Int. J. Cancer, 135, 2878, 10.1002/ijc.28929 Feigin, 2014, Mislocalization of the cell polarity protein Scribble promotes mammary tumorigenesis and is associated with basal breast cancer, Cancer Res., 74, 3180, 10.1158/0008-5472.CAN-13-3415 Greenwood, 2012, Stat1 and CD74 overexpression is co-dependent and linked to increased invasion and lymph node metastasis in triple-negative breast cancer, J. Proteome, 75, 3031, 10.1016/j.jprot.2011.11.033 Metodieva, 2013, CD74-dependent deregulation of the tumor suppressor Scribble in human epithelial and breast cancer cells, Neoplasia, 15, 660, 10.1593/neo.13464 Metodieva, 2009, A peptide-centric approach to breast cancer biomarker discovery utilizing label-free multiple reaction monitoring mass spectrometry, Proteomics Clin. Appl., 3, 78, 10.1002/prca.200800072 Murdoch, 2003, Disruption of Scribble (Scrb1) causes severe neural tube defects in the circletail mouse, Hum. Mol. Genet., 12, 87, 10.1093/hmg/ddg014 Nagasaka, 2010, The cell polarity regulator hScrib controls ERK activation through a KIM site-dependent interaction, Oncogene, 29, 5311, 10.1038/onc.2010.265 Nakajima, 2013, Epithelial junctions maintain tissue architecture by directing planar spindle orientation, Nature, 500, 359, 10.1038/nature12335 Nola, 2008, Scrib regulates PAK activity during the cell migration process, Hum. Mol. Genet., 17, 3552, 10.1093/hmg/ddn248 Olsen, 2006, Global, in vivo, and site-specific phosphorylation dynamics in signaling networks, Cell, 127, 635, 10.1016/j.cell.2006.09.026 Olsen, 2010, Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis, Sci. Signal., 3, 10.1126/scisignal.2000475 Qin, 2005, The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin, J. Cell Biol., 171, 1061, 10.1083/jcb.200506094 Savi, 2014, miR-296/Scribble axis is deregulated in human breast cancer and miR-296 restoration reduces tumour growth in vivo, Clin. Sci., 127, 233, 10.1042/CS20130580 Vaira, 2011, Aberrant overexpression of the cell polarity module Scribble in human cancer, Am. J. Pathol., 178, 2478, 10.1016/j.ajpath.2011.02.028 Young, 2013, An MRAS, SHOC2, and SCRIB complex coordinates ERK pathway activation with polarity and tumorigenic growth, Mol. Cell, 52, 679, 10.1016/j.molcel.2013.10.004 Zhan, 2008, Deregulation of Scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma, Cell, 135, 865, 10.1016/j.cell.2008.09.045