Decreased Expression of Intestinal P-glycoprotein Increases the Analgesic Effects of Oral Morphine in a Streptozotocin-induced Diabetic Mouse Model

Drug Metabolism and Pharmacokinetics - Tập 26 - Trang 584-591 - 2011
Ayaka Nawa1, Wakako Fujita-Hamabe1, Shiroh Kishioka2, Shogo Tokuyama1
1Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University, Kobe, Japan
2Department of Pharmacology, Wakayama Medical University, Wakayama, Japan

Tài liệu tham khảo

Glare, 2011, Choice of opioids and the WHO Ladder, J. Pediatr. Hematol. Oncol., 33, S6, 10.1097/MPH.0b013e3182121a2b Zelcer, 2005, Mice lacking multidrug resistance protein 3 show altered morphine pharmacokinetics and morphine-6-glucuronide antinociception, Proc. Natl. Acad. Sci. USA, 102, 7274, 10.1073/pnas.0502530102 Maeng, 2007, Functional induction of P-glycoprotein in the blood-brain barrier of streptozotocin-induced diabetic rats: evidence for the involvement of nuclear factor-kappaB, a nitrosative stress-sensitive transcription factor, in the regulation, Drug Metab. Dispos., 35, 1996, 10.1124/dmd.107.015800 Tomita, 2008, Assessment of ileal epithelial P-glycoprotein dysfunction induced by ischemia/reperfusion using in vivo animal model, Drug Metab. Pharmacokinet., 23, 356, 10.2133/dmpk.23.356 Kameyama, 2008, Increase in P-glycoprotein accompanied by activation of protein kinase Calpha and NF-kappaB p65 in the livers of rats with streptozotocin-induced diabetes, Biochim. Biophys. Acta, 1782, 355, 10.1016/j.bbadis.2008.02.005 Zong, 2000, Morphine antinociception is enhanced in mdr1a gene-deficient mice, Pharm. Res., 17, 749, 10.1023/A:1007546719287 Hamabe, 2007, Negative relationship between morphine analgesia and P-glycoprotein expression levels in the brain, J. Pharmacol. Sci., 105, 353, 10.1254/jphs.FP0071287 Tada, 2000, MDR1 gene overexpression and altered degree of methylation at the promoter region in bladder cancer during chemotherapeutic treatment, Clin. Cancer Res., 6, 4618 Komura, 2010, CD14+ monocytes are vulnerable and functionally impaired under endoplasmic reticulum stress in patients with type 2 diabetes, Diabetes, 59, 634, 10.2337/db09-0659 Shimizu, 2004, Role of pharmacokinetic effects in the potentiation of morphine analgesia by L-type calcium channel blockers in mice, J. Pharmacol. Sci., 94, 240, 10.1254/jphs.94.240 Kageyama, 2006, Relationship between excretion clearance of rhodamine 123 and P-glycoprotein (Pgp) expression induced by representative Pgp inducers, Biol. Pharm. Bull., 29, 779, 10.1248/bpb.29.779 Nawa, 2010, Inducible nitric oxide synthase-mediated decrease of intestinal P-glycoprotein expression under streptozotocin-induced diabetic conditions, Life Sci., 86, 402, 10.1016/j.lfs.2010.01.009 Han, 2006, Difference in oral absorption of ginsenoside Rg1 between in vitro and in vivo models, Acta Pharmacol. Sin., 27, 499, 10.1111/j.1745-7254.2006.00303.x Ganapathy, 2005, Transport systems for opioid peptides in mammalian tissues, AAPS J., 7, E852, 10.1208/aapsj070482 Mogi, 2011, Neurovascular coupling in cognitive impairment associated with diabetes mellitus, Circ. J., 75, 1042, 10.1253/circj.CJ-11-0121 Liu, 2006, Impaired function and expression of P-glycoprotein in blood-brain barrier of streptozotocin-induced diabetic rats, Brain Res., 1123, 245, 10.1016/j.brainres.2006.09.061 Ibironke, 2006, Effect of hyperglycemia on the efficacy of morphine analgesia in rats, Afr. J. Med. Med. Sci., 35, 443 Courteix, 1998, Is the reduced efficacy of morphine in diabetic rats caused by alterations of opiate receptors or of morphine pharmacokinetics?, J. Pharmacol. Exp. Ther., 285, 63 Nawa, 2011, Regulatory action of nitric oxide synthase on ileal P-glycoprotein expression under streptozotocin-induced diabetic condition, Biol. Pharm. Bull., 34, 436, 10.1248/bpb.34.436 Carmo, 2000, Effect of cyclosporin-A on the blood–retinal barrier permeability in streptozotocin-induced diabetes, Mediators Inflamm., 9, 243, 10.1080/09629350020025764 Leal, 2007, Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy, Invest. Ophthalmol. Vis. Sci., 48, 5257, 10.1167/iovs.07-0112 Thornalley, 2003, Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation endproducts, Arch. Biochem. Biophys., 419, 31, 10.1016/j.abb.2003.08.013 Abdel-Zaher, 2006, Attenuation of morphine tolerance and dependence by aminoguanidine in mice, Eur. J. Pharmacol., 540, 60, 10.1016/j.ejphar.2006.03.059 Xu, 2007, Proteasome-dependent degradation of guanosine 5′-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus, Circulation, 116, 944, 10.1161/CIRCULATIONAHA.106.684795 Bauer, 2007, Tumor necrosis factor alpha and endothelin-1 increase P-glycoprotein expression and transport activity at the blood-brain barrier, Mol. Pharmacol., 71, 667, 10.1124/mol.106.029512