Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States

Cell Systems - Tập 5 - Trang 105-118.e9 - 2017
Jong Wook Kim1,2,3, Omar O. Abudayyeh1, Huwate Yeerna4, Chen-Hsiang Yeang1,5, Michelle Stewart1, Russell W. Jenkins2, Shunsuke Kitajima2, David J. Konieczkowski1,6, Kate Medetgul-Ernar4, Taylor Cavazos4, Clarence Mah7,4, Stephanie Ting4, Eliezer M. Van Allen1,2, Ofir Cohen1,2, John Mcdermott1, Emily Damato1, Andrew J. Aguirre1,2,3, Jonathan Liang1, Arthur Liberzon1, Gabriella Alexe1,8,9,10
1Cancer Program, Eli and Edythe Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA
3Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02215, USA.
4Moores Cancer Center, University of California San Diego, La Jolla, CA 92103, USA
5Institute of Statistical Science, Academia Sinica, Taipei 11529, Taiwan
6Harvard Radiation Oncology Program, Massachusetts General Hospital, Boston, MA 02114, USA
7School of Medicine, University of California, San Diego, La Jolla, CA, 92093 USA
8Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA
9Boston Children’s Hospital, Harvard Medical School, Boston, MA, 02115, USA
10Graduate Program in Bioinformatics, Boston University, Boston, MA 02215, USA

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