Chuntao Yang1,2, Yingying Wang3,2, Eizo Marutani4, Tomoaki Ida5, Xiang Ni3, Shi Xu3, Wei Chen3, Hui Zhang1, Takaaki Akaike5, Fumito Ichinose4, Ming Xian3
1Affiliated Cancer Hospital & Institute, Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Medical University Guangzhou 510095 China
2these authors contributed equally to this work
3Dept. Chemistry, Washington State University, Pullman, 99164 WA, USA
4Dept. Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital/Harvard Medical School, Boston, MA, 02114 USA
5Department of Environmental Medicine and Molecular Toxicology, Tohoku University, Sendai, 980-8575 Japan
Tóm tắt
AbstractHydrogen sulfide (H2S) is an important signaling molecule whose up‐ and down‐regulation have specific biological consequences. Although significant advances in H2S up‐regulation, by the development of H2S donors, have been achieved in recent years, precise H2S down‐regulation is still challenging. The lack of potent/specific inhibitors for H2S‐producing enzymes contributes to this problem. We expect the development of H2S scavengers is an alternative approach to address this problem. Since chemical sensors and scavengers of H2S share the same criteria, we constructed a H2S sensor database, which summarizes key parameters of reported sensors. Data‐driven analysis led to the selection of 30 potential compounds. Further evaluation of these compounds identified a group of promising scavengers, based on the sulfonyl azide template. The efficiency of these scavengers in in vitro and in vivo experiments was demonstrated.
