DNA methylation-based measures of biological age: meta-analysis predicting time to death

Aging - Tập 8 Số 9 - Trang 1844-1865 - 2016
Brian H. Chen1,2,3, Riccardo E. Marioni4,5,6, Elena Colicino7, Mark Peters8, Cavin Ward‐Caviness9, Pei-Chien Tsai10, Nicholas S. Roetker11, Allan C. Just7, Ellen W. Demerath11, Weihua Guan12, Jan Bressler13, Myriam Fornage13,14, Stephanie Studenski1, Amy R. Vandiver15, Ann Zenobia Moore1, Toshiko Tanaka1, Douglas P. Kiel16,17,18, Liming Liang19, Pantel Vokonas20, Joel Schwartz20, Kathryn L. Lunetta21,3, Joanne M. Murabito22,3, Stefania Bandinelli23, Dena Hernández24, David Melzer25, Henry Houlden24, Luke C. Pilling25, T. Ryan Price24, Andrew T. Hattersley24, Christian Gieger9,26, Rolf Holle27, Anja Kretschmer9,26, Florian Kronenberg28, Sonja Kunze9,26, Jakob Linseisen9, Christa Meisinger9, Wolfgang Rathmann29, Mélanie Waldenberger9,26, Peter M. Visscher4,6,30, Sonia Shah6,30, Naomi R. Wray6, Allan F. McRae6,30, Oscar H. Franco31, Albert Hofman32,31, André G. Uitterlinden31,8, Devin Absher33, Themistocles L. Assimes34, Morgan E. Levine35, Ake T. Lu35, Philip S. Tsao34,36, Lifang Hou37,38, JoAnn E. Manson39, Cara L. Carty40, Andrea Z. LaCroix41, Alexander P. Reiner42,43, Tim D. Spector10, Andrew P. Feinberg15,2, Daniel Levy44,3, Andrea Baccarelli45,7, Joyce B. J. van Meurs8, Jordana T. Bell10, Annette Peters9, Ian J. Deary4,46, James S. Pankow11, Luigi Ferrucci1, Steve Horvath46,35
1Longitudinal Studies Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA
2Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 01702, USA
3The NHLBI’s Framingham Heart Study, Framingham, MA, 01702, USA
4Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK
5Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK
6Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia
7Laboratory of Environmental Epigenetics, Departments of Environmental Health Sciences and Epidemiology, Columbia University Mailman School of Public Health, New York, NY 10032, USA
8Department of Internal Medicine, Erasmus University Medical Centre, Rotterdam, 3000 CA, The Netherlands
9Institute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg, Germany
10Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK
11Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55455, USA
12Division of Biostatistics, University of Minnesota School of Public Health, Minneapolis, MN 55455, USA
13Human Genetics Center, School of Public Health, University of Texas Health Sciences Center at Houston, Houston, TX, ; USA
14Human Genome Sequencing Center, Baylor College of Medicine Houston TX USA
15Center for Epigenetics, Johns Hopkins University, Baltimore, MD 21205, USA
16Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
17Institute for Aging Research, Hebrew Senior Life, Boston, MA 02215, USA
18www.aging-us.com Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
19Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
20Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115 USA
21Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
22Section of General Internal Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
23Geriatric Unit, Usl Centro Toscana, Florence, Italy
24Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20814, USA
25Epidemiology and Public Health, Medical School, University of Exeter, RILD, Exeter EX2 5DW, ; UK
26Research unit of Molecular Epidemiology, Helmholtz Zentrum München, 85764, Neuherberg, Germany
27Institute of Health Economics and Health Care Management, Helmholtz Zentrum München, 85764, Neuherberg, Germany
28Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck 6020, Austria
29Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, 40225 Düsseldorf, Germany
30University of Queensland Diamantina Institute, University of Queensland, Brisbane, Queensland, Australia
31Department of Epidemiology, Erasmus University Medical Centre, Rotterdam, 3015 CN, The Netherlands 31 HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA 32 Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; 33 Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA 34 VA Palo Alto Health Care System, Palo Alto CA 94304, USA 35 Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University Chicago, IL 60611, USA 36 Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University Chicago, IL 60611, USA 37 Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, and the Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA 38 Center for Translational Science Children's National Medical Center, George Washington University Washington, DC 20010, USA 39 Department of Family Medicine and Public Health, University of California-San Diego, La Jolla, CA 92093-0725, USA 40 Department of Epidemiology, University of Washington School of Public Health, Seattle, WA 98195, USA 41 Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA 42 Departments of Medicine, Molecular Biology/Genetics, Oncology, and Biostatistics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA 43 Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 01702, USA 44 Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA 45 Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK 46 Department of Biostatistics, School of Public Health, University of California Los Angeles, Los Angeles, CA 90095, USA
32Department of Epidemiology, Erasmus University Medical Centre, Rotterdam, 3015 CN, The Netherlands
33HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA
34Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, ; Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
35VA Palo Alto Health Care System, Palo Alto, CA, 94304, USA
36Department of Preventive Medicine, Feinberg School of Medicine, Northwestern UniversityChicago, IL 60611, USA
37Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, and the Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA
38Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern UniversityChicago, IL 60611, USA
39Center for Translational Science Children’s National Medical Center, George Washington University, Washington, DC 20010, USA
40Department of Family Medicine and Public Health, University of California-San Diego, La Jolla, CA 92093-0725, ; USA
41Department of Epidemiology, University of Washington School of Public Health, Seattle, WA 98195, USA
42Departments of Medicine, Molecular Biology/Genetics, Oncology, and Biostatistics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
43Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA,
44Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA
45Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK
46Department of Biostatistics, School of Public Health, University of California Los Angeles, Los Angeles, CA, 90095, USA

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Aging

Tập 8 Số 9

1844-1865

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