DNA-PK inhibition by M3814 enhances chemosensitivity in non-small cell lung cancer
Tài liệu tham khảo
Gerard, 2009, Immunotherapy in the landscape of new targeted treatments for non-small cell lung cancer, Mol Oncol, 3, 409, 10.1016/j.molonc.2009.09.001
Sandler, 2003, Chemotherapy for small cell lung cancer, Semin Oncol, 30, 9, 10.1053/sonc.2003.50012
Lackey, 2013, Surgical management of lung cancer, Semin Intervent Radiol, 30, 133, 10.1055/s-0033-1342954
Mountain, 1997, Regional lymph node classification for lung cancer staging, Chest, 111, 1718, 10.1378/chest.111.6.1718
Johnston, 2004, Ovarian cancer: review of the national institute for clinical excellence (NICE) guidance recommendations, Cancer Invest, 22, 730, 10.1081/CNV-200032761
Ward, 1990, The yield of DNA double-strand breaks produced intracellularly by ionizing radiation: a review, Int J Radiat Biol, 57, 1141, 10.1080/09553009014551251
Iliakis, 1991, The role of DNA double strand breaks in ionizing radiation-induced killing of eukaryotic cells, Bioessays, 13, 641, 10.1002/bies.950131204
Zhuang, 2011, Induction of autophagy promotes differentiation of glioma-initiating cells and their radiosensitivity, Int J Cancer, 129, 2720, 10.1002/ijc.25975
Mao, 2008, DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells, Cell Cycle, 7, 2902, 10.4161/cc.7.18.6679
Mahaney, 2009, Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining, Biochem J, 417, 639, 10.1042/BJ20080413
Lieber, 2008, The mechanism of human nonhomologous DNA end joining, J Biol Chem, 283, 1, 10.1074/jbc.R700039200
Chan, 2002, Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks, Genes Dev, 16, 2333, 10.1101/gad.1015202
Gottlieb, 1993, The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen, Cell, 72, 131, 10.1016/0092-8674(93)90057-W
Davidson, 2013, Small molecules, inhibitors of DNA-PK, targeting DNA repair, and beyond, Front Pharmacol, 4, 5, 10.3389/fphar.2013.00005
Mari, 2006, Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4, Proc Natl Acad Sci U S A, 103, 18597, 10.1073/pnas.0609061103
Britton, 2013, A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair, J Cell Biol, 202, 579, 10.1083/jcb.201303073
Shao, 2012, Persistently bound Ku at DNA ends attenuates DNA end resection and homologous recombination, DNA Repair, 11, 310, 10.1016/j.dnarep.2011.12.007
Uematsu, 2007, Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks, J Cell Biol, 177, 219, 10.1083/jcb.200608077
Cary, 1997, DNA looping by Ku and the DNA-dependent protein kinase, Proc Natl Acad Sci U S A, 94, 4267, 10.1073/pnas.94.9.4267
DeFazio, 2002, Synapsis of DNA ends by DNA-dependent protein kinase, EMBO J, 21, 3192, 10.1093/emboj/cdf299
Weterings, 2004, The mechanism of non-homologous end-joining: a synopsis of synapsis, DNA Repair, 3, 1425, 10.1016/j.dnarep.2004.06.003
Yoo, 1999, Geometry of a complex formed by double strand break repair proteins at a single DNA end: recruitment of DNA-PKcs induces inward translocation of Ku protein, Nucleic Acids Res, 27, 4679, 10.1093/nar/27.24.4679
Calsou, 1999, The DNA-dependent protein kinase catalytic activity regulates DNA end processing by means of Ku entry into DNA, J Biol Chem, 274, 7848, 10.1074/jbc.274.12.7848
Xing, 2008, Prognostic significance of ataxia-telangiectasia mutated, DNA-dependent protein kinase catalytic subunit, and Ku heterodimeric regulatory complex 86-kD subunit expression in patients with nonsmall cell lung cancer, Cancer, 112, 2756, 10.1002/cncr.23533
Shintani, 2003, Up-regulation of DNA-dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma, Cancer Sci, 94, 894, 10.1111/j.1349-7006.2003.tb01372.x
Tian, 2007, The relationship between the down-regulation of DNA-PKcs or Ku70 and the chemosensitization in human cervical carcinoma cell line HeLa, Oncol Rep, 18, 927
Beskow, 2009, Radioresistant cervical cancer shows upregulation of the NHEJ proteins DNA-PKcs, Ku70 and Ku86, Br J Cancer, 101, 816, 10.1038/sj.bjc.6605201
Bouchaert, 2012, DNA-PKcs expression predicts response to radiotherapy in prostate cancer, Int J Radiat Oncol Biol Phys, 84, 1179, 10.1016/j.ijrobp.2012.02.014
Fok, 2019, AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity, Nat Commun, 10, 5065, 10.1038/s41467-019-12836-9
Fuchss, 2017, Abstract 4198: highly potent and selective DNA-PK inhibitor M3814 with sustainable anti-tumor activity in combination with radiotherapy, Cancer Res, 77, 4198, 10.1158/1538-7445.AM2017-4198
Wise, 2019, Activity of M3814, an oral DNA-PK inhibitor, in combination with topoisomerase II inhibitors in ovarian cancer models, Sci Rep, 9, 18882, 10.1038/s41598-019-54796-6
Zimmermann, 2019, Abstract 269: DNA-PK inhibitor, M3814, as a new combination partner of mylotarg in the treatment of acute myeloid leukemia, Cancer Res, 79, 269, 10.1158/1538-7445.AM2019-269
Klein, 2017, Overcoming hypoxia-induced tumor radioresistance in non-small cell lung cancer by targeting DNA-dependent protein kinase in combination with carbon ion irradiation, Radiat Oncol, 12, 208, 10.1186/s13014-017-0939-0
Chou, 1984, Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors, Adv Enzym Regul, 22, 27, 10.1016/0065-2571(84)90007-4
Bunz, 1998, Requirement for p53 and p21 to sustain G2 arrest after DNA damage, Science, 282, 1497, 10.1126/science.282.5393.1497
Mah, 2010, gammaH2AX: a sensitive molecular marker of DNA damage and repair, Leukemia, 24, 679, 10.1038/leu.2010.6
Deckbar, 2007, Chromosome breakage after G2 checkpoint release, J Cell Biol, 176, 749, 10.1083/jcb.200612047
Lopez-Otin, 2013, The hallmarks of aging, Cell, 153, 1194, 10.1016/j.cell.2013.05.039
Azad, 2011, Inhibition of DNA-dependent protein kinase induces accelerated senescence in irradiated human cancer cells, Mol Cancer Res, 9, 1696, 10.1158/1541-7786.MCR-11-0312
Campisi, 2007, Cellular senescence: when bad things happen to good cells, Nat Rev Mol Cell Biol, 8, 729, 10.1038/nrm2233
Shay, 2004, Hallmarks of senescence in carcinogenesis and cancer therapy, Oncogene, 23, 2919, 10.1038/sj.onc.1207518
Aliouat-Denis, 2005, p53-independent regulation of p21Waf1/Cip 1 expression and senescence by Chk2, Mol Cancer Res, 3, 627, 10.1158/1541-7786.MCR-05-0121
Senoo, 2001, Transcriptional dysregulation of the p73L/p63/p51/p40/KET gene in human squamous cell carcinomas: expression of Delta Np73L, a novel dominant-negative isoform, and loss of expression of the potential tumour suppressor p51, Br J Cancer, 84, 1235, 10.1054/bjoc.2000.1735
Drapkin, 2018, Genomic and functional fidelity of small cell lung cancer patient-derived xenografts, Cancer Discov, 8, 600, 10.1158/2159-8290.CD-17-0935
Zhao, 2006, Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441, Cancer Res, 66, 5354, 10.1158/0008-5472.CAN-05-4275
Qin, 2019, Weekly albumin-bound paclitaxel/cisplatin versus gemcitabine/cisplatin as first-line therapy for patients with advanced non-small-cell lung cancer: a phase II open-label clinical study, Chin J Cancer Res, 31, 339, 10.21147/j.issn.1000-9604.2019.02.08
Liang, 2017, Etoposide and cisplatin versus paclitaxel and carboplatin with concurrent thoracic radiotherapy in unresectable stage III non-small cell lung cancer: a multicenter randomized phase III trial, Ann Oncol, 28, 777, 10.1093/annonc/mdx009
Eberhardt, 2015, Concurrent chemoradiotherapy in stage III non-small-cell lung cancer: what is the best regimen?., J Clin Oncol, 33, 532, 10.1200/JCO.2014.58.9812
Madhavan, 2007, Simple laboratory methods to measure cell proliferation using DNA synthesis property, J Stem Cells Regen Med, 3, 12, 10.46582/jsrm.0301003
Lama-Sherpa, 2020, An Emerging regulatory role for the tumor microenvironment in the DNA damage response to double-strand breaks, Mol Cancer Res, 18, 185, 10.1158/1541-7786.MCR-19-0665
Redon, 2002, Histone H2A variants H2AX and H2AZ, Curr Opin Genet Dev, 12, 162, 10.1016/S0959-437X(02)00282-4
Branham, 2004, DNA damage induced by paclitaxel and DNA repair capability of peripheral blood lymphocytes as evaluated by the alkaline comet assay, Mutat Res, 560, 11, 10.1016/j.mrgentox.2004.01.013
Mikula-Pietrasik, 2019, Comprehensive review on how platinum- and taxane-based chemotherapy of ovarian cancer affects biology of normal cells, Cell Mol Life Sci, 76, 681, 10.1007/s00018-018-2954-1
Poruchynsky, 2015, Microtubule-targeting agents augment the toxicity of DNA-damaging agents by disrupting intracellular trafficking of DNA repair proteins, Proc Natl Acad Sci U S A, 112, 1571, 10.1073/pnas.1416418112
Birinci, 2017, The effect of pycnogenol and paclitaxel on DNA damage in human breast cancer cell line, Proceedings, 1, 1023, 10.3390/proceedings1101023
Davis, 2014, DNA-PK: a dynamic enzyme in a versatile DSB repair pathway, DNA Repair, 17, 21, 10.1016/j.dnarep.2014.02.020
Cui, 2005, Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice, Mol Cell Biol, 25, 10842, 10.1128/MCB.25.24.10842-10852.2005
Meek, 2007, Trans Autophosphorylation at DNA-dependent protein kinase's two major autophosphorylation site clusters facilitates end processing but not end joining, Mol Cell Biol, 27, 3881, 10.1128/MCB.02366-06
Faget, 2019, Unmasking senescence: context-dependent effects of SASP in cancer, Nat Rev Cancer, 19, 439, 10.1038/s41568-019-0156-2
Boohaker, 2014, The versatile functions of ATM kinase, Biomed J, 37, 3, 10.4103/2319-4170.125655
Yan, 2014, Interleukin 6 augments lung cancer chemotherapeutic resistance via ataxia-telangiectasia mutated/NF-kappaB pathway activation, Cancer Sci, 105, 1220, 10.1111/cas.12478
Hsia, 2016, Isoliquiritigenin as a cause of DNA damage and inhibitor of ataxia-telangiectasia mutated expression leading to G2/M phase arrest and apoptosis in oral squamous cell carcinoma, Head Neck, 38 Suppl 1, E360, 10.1002/hed.24001
Wang, 2015, DNA damage checkpoint recovery and cancer development, Exp Cell Res, 334, 350, 10.1016/j.yexcr.2015.03.011
Blagosklonny, 2011, Cell cycle arrest is not senescence, Aging, 3, 94, 10.18632/aging.100281
d'Adda di Fagagna, 2008, Living on a break: cellular senescence as a DNA-damage response, Nat Rev Cancer, 8, 512, 10.1038/nrc2440
Gewirtz, 2008, Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiation, Biochem Pharmacol, 76, 947, 10.1016/j.bcp.2008.06.024