DJ-1 knock-down in astrocytes impairs astrocyte-mediated neuroprotection against rotenone

Aleyasin, 2007, The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage, PNAS, 104, 18748, 10.1073/pnas.0709379104 Andres-Mateos, 2007, DJ-1 Gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase, PNAS, 104, 14807, 10.1073/pnas.0703219104 Ascherio, 2006, Pesticide exposure and risk for Parkinson's disease, Ann. Neurol., 60, 197, 10.1002/ana.20904 Bandopadhyay, 2004, The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease, Brain, 127, 420, 10.1093/brain/awh054 Betarbet, 2000, Chronic systemic pesticide exposure reproduces features of Parkinson's disease, Nature Neurosci., 12, 1301, 10.1038/81834 Bonifati, 2003, Mutations in the DJ-1 gene associated with autosomal recessive early-onset Parkinsonism, Science, 299, 256, 10.1126/science.1077209 Brown, 2006, Pesticides and Parkinson's disease — is there a link?, Env. Health Perspectives, 114, 156, 10.1289/ehp.8095 Castellani, 2002, Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans, Neuroscie. Lett., 319, 25, 10.1016/S0304-3940(01)02514-9 Clements, 2006, DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2, PNAS, 103, 15091, 10.1073/pnas.0607260103 Damier, 1993, Glutathione peroxidase, glial cells and Parkinson's disease, Neuroscience, 52, 1, 10.1016/0306-4522(93)90175-F Dexter, 1991, Alteration in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia, Brain, 114, 1953, 10.1093/brain/114.4.1953 Dringen, 1999, Synthesis of the antioxidant glutathione in neurons: supply by astrocytes of CysGly as precursor for neuronal glutathione, J. Neurosci., 19, 562, 10.1523/JNEUROSCI.19-02-00562.1999 Fan, 2008, DJ-1 decreases Bax expression through repressing p53 transcriptional activity, JBC, 283, 4022, 10.1074/jbc.M707176200 Gegg, 2003, Differential effect of nitric oxide on glutathione metabolism and mitochondrial function in astrocytes and neurons: implications for neuroprotection/neurodegeneration?, J. Neurochemistry, 86, 228, 10.1046/j.1471-4159.2003.01821.x Giasson, 2000, Oxidative damage linked to neurodegeneration by selective α-synuclein nitration in synucleinopathy lesions, Science, 290, 985, 10.1126/science.290.5493.985 Good, 1998, Protein nitration in Parkinson's disease, J. Neuropath. and Exp. Neurology, 57, 338, 10.1097/00005072-199804000-00006 Gorner, 2007, Structural determinants of the C-terminal helix-kink-helix motif essential for protein stability and survival promoting activity of DJ-1, J. Biol. Chem., 282, 13680, 10.1074/jbc.M609821200 Inden, 2006, PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat model, Neurobiol. Dis., 24, 144, 10.1016/j.nbd.2006.06.004 Junn, 2005, Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death, PNAS, 102, 9691, 10.1073/pnas.0409635102 Laemmli, 1970, Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature, 227, 680, 10.1038/227680a0 Makar, 1994, Vitamin E, ascorbate, glutathione, glutathione disulfide, and enzymes of glutathione metabolism in cultures of chick astrocytes and neurons: evidence that astrocytes play an important role in antioxidant processes in the brain, J. Neurochemistry, 62, 45, 10.1046/j.1471-4159.1994.62010045.x Meulener, 2006, Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging, PNAS, 103, 12517, 10.1073/pnas.0601891103 Mullett, S., Hamilton, R., Hinkle, D., in press. DJ-1 immunoreactivity in human brain astrocytes is dependent on infarct presence and infarct age. Neuropathology. Neumann, 2004, Pathological properties of the Parkinson's disease-associated protein DJ-1 in α-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's disease, Acta Neuropath., 107, 489, 10.1007/s00401-004-0834-2 Rizzu, 2004, DJ-1 co-localizes with pathological tau inclusions: a link between Parkinsonism and dementia, Ann. Neurol., 55, 113, 10.1002/ana.10782 Sagara, 1993, Maintenance of neuronal glutathione by glial cells, J. Neurochemistry, 61, 1672, 10.1111/j.1471-4159.1993.tb09802.x Sagara, 1996, Glutathione efflux from cultured astrocytes, J. Neurochemistry, 66, 1876, 10.1046/j.1471-4159.1996.66051876.x Schipper, 1998, Neural heme oxygenase-1 expression in idiopathic Parkinson's disease, Exp. Neurol., 150, 60, 10.1006/exnr.1997.6752 Sherer, 2002, An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered α-synuclein metabolism and oxidative damage, J. Neuroscience, 16, 7006, 10.1523/JNEUROSCI.22-16-07006.2002 Shinbo, 2006, Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities, Cell Death Differ., 13, 96, 10.1038/sj.cdd.4401704 Sian, 1994, Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia, Ann. Neurol., 36, 348, 10.1002/ana.410360305 Taira, 2004, DJ-1 has a role in antioxidative stress to prevent cell death, EMBO Reports, 5, 213, 10.1038/sj.embor.7400074 Vila, 2001, The role of glial cells in Parkinson's disease, Curr. Opin. Neurol., 14, 483, 10.1097/00019052-200108000-00009 Wang, 2000, Astrocytes provide cysteine to neurons by releasing glutathione, J. Neurochem., 74, 1434, 10.1046/j.1471-4159.2000.0741434.x Xu, 2005, The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis, Human Mol. Genetics, 14, 1231, 10.1093/hmg/ddi134 Yoritaka, 1996, Immunohistochemical detection of 4-hydroxynonenol protein adducts in Parkinson disease, PNAS, 93, 2701, 10.1073/pnas.93.7.2696 Zhang, 1999, Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons, Am. J. Pathol., 154, 1423, 10.1016/S0002-9440(10)65396-5 Zhou, 2005, DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T α-synuclein toxicity, J. Biol. Chem., 280, 43150, 10.1074/jbc.M507124200