DAP10 integration in CAR-T cells enhances the killing of heterogeneous tumors by harnessing endogenous NKG2D

Molecular Therapy - Oncolytics - Tập 26 - Trang 15-26 - 2022
Shanglin Li1,2, Ruocong Zhao3,4, Diwei Zheng1,2, Le Qin1, Yuanbin Cui1,2, Yao Li1,2, Zhiwu Jiang1, Mengjun Zhong3, Jingxuan Shi1, Ming Li5, Xindong Wang6, Zhaoyang Tang7,8, Qiting Wu1, Youguo Long1, Duo Hu6, Suna Wang1, Yao Yao1, Shuang Liu9, Li-Hua Yang10, Zhenfeng Zhang11
1China-New Zealand Joint Laboratory of Biomedicine and Health, State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China
2University of Chinese Academy of Sciences, Beijing, China
3Institute of Hematology, Medical College, Jinan University, Guangzhou, China
4Centre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences, Hong Kong SAR, China
5Anhui University, Hefei, China
6Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, China
7Guangdong Zhaotai InVivo Biomedicine Co. Ltd., Guangzhou, China
8Guangdong Zhaotai Cell Biology Technology, Ltd., Foshan, China
9Department of Hematology, Guangdong Second Provincial General Hospital, Guangzhou, China
10Department of Pediatric Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China
11Department of Radiology, Translational Provincial Education Department Key Laboratory of Nano-Immmunoregulation Tumor Microenvironment, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China

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