Cytoplasmic Syncytial Connections Between Neuron Bodies in the CNS of Adult Animals
Tóm tắt
Studies of neurons in the dentate gyrus and hippocampal fields CA1 and CA2 and cerebellar granule cells were performed to test the hypothesis that there are syncytial connections between the bodies of neurons in adult higher vertebrates. Electron microscopic investigations showed that these cells were densely packed and had incomplete glial coatings. The outer cell membranes of these cells were found to be in contact, and membrane contacts in the form of tight junctions and gap junctions were seen. These areas showed membrane perforation and the establishment of syncytial connections between neurons, with all the expected ultrastructural characteristics. These connections could form between several contacting neurons, resulting in a unified functional cell cluster. These studies support the hypothesis that cytoplasmic syncytial interneuronal connections, along with synaptic and contact-type electrical connections, form not only in tissue cultures and the autonomic nervous system during early postnatal ontogenesis, but also in the CNS in adult vertebrates.
Tài liệu tham khảo
J. Gibbs, “A method for the geometric representation of thermodynamic properties of substances using surfaces,” in: Thermodynamics. Statistical Mechanics [Russian translation], Nauka, Moscow (1982), pp. 40–60.
N. P. Larionova, N. V. Samosudova, and L. M. Chailokhyan, “Effects of L-glutamate on the structure of frog cerebellar granule cells in vitro,” Dokl. Akad. Nauk SSSR, 333, No. 2, 260–263 (1993).
N. M. Paramonova, “Characteristics of ultrastructural changes of hippocampal dentate gyrus neurons during the acute period of gunshot craniocerebral trauma,” Morfologiya, 129, No. 2, 74 (2006).
N. Ringertz and R. Savage, Hybrid Cells [Russian translation], Mir, Moscow (1979).
N. V. Sanosudova, V. P. Reutov, N. P. Larionova, and L. M. Chailakhyan, “Neuron-glial contacts formed in the cerebellum on electrical stimulation in the presence of an NO-generating compound,” Morfologiya, 131, No. 2, 53–58 (2007).
V. V. Semchenko, N. N. Bogolepov, and S. S. Stepanov, The Synaptoarchitectonics of the Cerebral Cortex [in Russian], Omich, Omsk (1995).
O. S. Sotnikov, Dynamics of the Structure of Live Neurons [in Russian], Nauka, Leningrad (1985).
O. S. Sotnikov, “The non-electrical functions of neurons,” Ros. Fiziol. Zh. 87, No. 2, 204–216 (2001).
O. S. Sotnikov, “Non-myelinated nerve fibers,” Morfologiya, 123, No. 2, 88–96 (2003).
O. S. Sotnikov,V. V. Malashko, and G. I. Rybakova, “The phenomenon of nerve fiber fusion,” Dokl. Ros. Akad. Nauk., 410, No. 1, 130–133 (2006).
O. S. Sotnikov, V. V. Malashko, and G. I. Rybakova, “Syncytial connections of neurons in tissue cultures in early ontogenesis,” Morfologiya, 131, No. 2, 7–15 (2007).
G. D. Bittner, “Degeneration and regeneration in Crustacean neuromuscular systems,” Amer. Zool., 13, 379–408 (1973).
M. S. Bouton and G. D. Bittner, “Regeneration of motor axons in crayfish limbs: Distal stump activation followed by synaptic reformation,” Cell Tiss. Res., 219, 379–392 (1981).
J. N. Carr and P. H. Taghert, “Formation of the transverse nerve in moth embryos. II. Stereotyped growth by the axons of identified neuroendocrine neurons,” Dev. Biol., 130, No. 2, 500–512 (1988).
G. I. Hatton, “Cellular reorganization in neuroendocrine secretion,” in: Stimulus-Secretion Coupling in Neuroendocrine Systems. Current Topics in Neuroendocrinology, Springer Verlag, Berlin, etc. (1988), pp. 1–27.
A. Jeremic,W. Jin Cho, and B. P. Jena, “Cholesterol is critical to the integrity of neuronal porosome/fission pore,” Ultramicroscopy, 106, No. 8–9, 674–677 (2006).
P. Y. Pan, Q. Cai, L. Lin, et al., “SNAP-29-mediated modulation of synaptic transmission in cultured hippocampal neurons,” J. Biol. Chem., 280, No. 27, 25769–25779 (2005).
A. Pienado, “Immature neocortical neurons exist as extensive syncytial networks linked by dendrodendritic electrical connections,” J. Neurophysiol., 85, No. 2, 620–629 (2001).
R. R. Poznanski and O. Umino, “Syncytial integration by a network of coupled bipolar cells in the retina,” Prog. Neurobiol., 53, No. 3, 273–291 (1997).
J. Pysh and R. Willey, “Morphological alteration of synapse in electrically stimulation superior cervical ganglion of the cat,” Science, 176, 191–193 (1972).
P. Vanden Berghe and J. Klingauf, “Spatial organization and dynamic properties of neurotransmitter release sites in the enteric nervous system,” Neurosci., 145, No. 1, 88–99 (2007).
J. Z. Young, “Structure of nerve fibres and synapses in some invertebrates,” Cold Spring Harb. Symp. Quant. Biol., 4, No. 4, 1–6 (1936).