Cytoplasmic DNA sensing by KU complex in aged CD4+ T cell potentiates T cell activation and aging-related autoimmune inflammation

Immunity - Tập 54 - Trang 632-647.e9 - 2021
Yan Wang1, Zunyun Fu2,3, Xutong Li2, Yinming Liang4, Siyu Pei1, Shumeng Hao1, Qingchen Zhu1, Tao Yu1, Yifei Pei1, Jia Yuan1, Jialin Ye1, Jiemeng Fu1, Jing Xu1, Jin Hong1,5, Ruirui Yang2,6, Hui Hou2, Xinfang Huang7, Chao Peng8, Mingyue Zheng2, Yichuan Xiao1
1CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China
2Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 201203, China
3School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China
4School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, 453003, China
5Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
6Shanghai Institute for Advanced Immunochemical Studies, and School of Life Science and Technology, ShanghaiTech University, Shanghai, 200031, China
7Department of Rheumatology, Shanghai East Hospital, Tongji University, School of Medicine, Shanghai 200120, China
8National Facility for Protein Science in Shanghai, Zhangjiang Lab, Shanghai, 201210, China

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