Cytomegalovirus retinitis associated with HIV in resource-constrained settings: systematic screening and case detection

Antiretroviral Therapy Cohort, 2008, Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies, Lancet, 372, 293, 10.1016/S0140-6736(08)61113-7 El-Sadr, 2006, CD4+ count-guided interruption of antiretroviral treatment, N Engl J Med, 355, 2283, 10.1056/NEJMoa062360 Lawn, 2008, Early mortality among adults accessing antiretroviral treatment programmes in sub-Saharan Africa, AIDS, 22, 1897, 10.1097/QAD.0b013e32830007cd Braitstein, 2006, Mortality of HIV-1-infected patients in the first year of antiretroviral therapy: comparison between low-income and high-income countries, Lancet, 367, 817, 10.1016/S0140-6736(06)68337-2 WHO/UNAIDS/UNICEF. Towards universal access. Scaling up priority HIV/AIDS interventions in the health sector. Geneva: WHO; 2010. http://www.who.int/hiv/pub/2010progressreport/summary_en.pdf [accessed 1 December 2010]. Kestelyn, 2001, HIV/AIDS and blindness, Bull World Health Organ, 79, 208 Guex-Crosier, 2001, An epidemic of blindness: a consequence of improved HIV care?, Bull World Health Organ, 79, 181 Heiden, 2007, Cytomegalovirus retinitis: the neglected disease of the AIDS pandemic, PLoS Med, 4, e334, 10.1371/journal.pmed.0040334 Otiti-Sengeri, 2008, Ocular immune reconstitution inflammatory syndromes, Curr Opin HIV AIDS, 3, 432, 10.1097/COH.0b013e328302cc3d Adjei, 2008, Seroprevalence of HHV-8, CMV, and EBV among the general population in Ghana, West Africa, BMC Infect Dis, 8, 111, 10.1186/1471-2334-8-111 Cannon, 2010, Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection, Rev Med Virol, 20, 202, 10.1002/rmv.655 Rabenau, 2010, Prevalence- and gender-specific immune response to opportunistic infections in HIV-infected patients in Lesotho, Sex Transm Dis, 37, 454, 10.1097/OLQ.0b013e3181cfcc2b Ausayakhun, 2003, Epidemiology of the ocular complications of HIV infection in Chiang Mai, J Med Assoc Thai, 86, 399 Gharai, 2008, Ophthalmic manifestations of HIV infections in India in the era of HAART: analysis of 100 consecutive patients evaluated at a tertiary eye care center in India, Ophthalmic Epidemiol, 15, 264, 10.1080/09286580802077716 Pathai, 2009, Prevalence of HIV-associated ophthalmic disease among patients enrolling for antiretroviral treatment in India: a cross-sectional study, BMC Infect Dis, 9, 158, 10.1186/1471-2334-9-158 Shah, 2009, Evaluation of ocular manifestations and blindness in HIV/AIDS patients on HAART in a tertiary care hospital in western India, Br J Ophthalmol, 93, 88, 10.1136/bjo.2008.149237 Jaffar, 1999, Retinal manifestations of HIV-1 and HIV-2 infections among hospital patients in The Gambia, west Africa, Trop Med Int Health, 4, 487, 10.1046/j.1365-3156.1999.00425.x Lewallen, 1994, Retinal findings in Malawian patients with AIDS, Br J Ophthalmol, 78, 757, 10.1136/bjo.78.10.757 Kestelyn, 1999, The epidemiology of CMV retinitis in Africa, Ocul Immunol Inflamm, 7, 173, 10.1076/ocii.7.3.173.4002 Nkomazana, 2008, Ocular complications of HIV infection in sub-Sahara Africa, Curr HIV/AIDS Rep, 5, 120, 10.1007/s11904-008-0019-z Pathai, 2011, Differing spectrum of HIV-associated ophthalmic disease among patients initiating antiretroviral therapy in India and South Africa, Trop Med Int Health, 16, 356, 10.1111/j.1365-3156.2010.02712.x Hoover, 1996, Occurrence of cytomegalovirus retinitis after human immunodeficiency virus immunosuppression, Arch Ophthalmol, 114, 821, 10.1001/archopht.1996.01100140035004 Palella, 1998, Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators, N Engl J Med, 338, 853, 10.1056/NEJM199803263381301 Holland, 2008, AIDS and ophthalmology: the first quarter century, Am J Ophthalmol, 145, 397, 10.1016/j.ajo.2007.12.001 Jacobson, 2000, Natural history and outcome of new AIDS-related cytomegalovirus retinitis diagnosed in the era of highly active antiretroviral therapy, Clin Infect Dis, 30, 231, 10.1086/313612 Kuppermann, 1993, Correlation between CD4+ counts and prevalence of cytomegalovirus retinitis and human immunodeficiency virus-related noninfectious retinal vasculopathy in patients with acquired immunodeficiency syndrome, Am J Ophthalmol, 115, 575, 10.1016/S0002-9394(14)71453-9 Pertel, 1992, Risk of developing cytomegalovirus retinitis in persons infected with the Human Immunodeficiency Virus, J Acquir Immune Defic Syndr, 5, 1069 Gallant, 1992, Incidence and natural history of cytomegalovirus disease in patients with advanced human immunodeficiency virus disease treated with zidovudine. The Zidovudine Epidemiology Study Group, J Infect Dis, 166, 1223, 10.1093/infdis/166.6.1223 Morlat, 1998, The presence of cotton-wool spots is predictive for the development of CMV retinitis, Int J STD AIDS, 9, 122 Jabs, 1995, Ocular manifestations of HIV infection, Trans Am Ophthalmol Soc, 93, 623 Bowen, 1995, Natural history of untreated cytomegalovirus retinitis, Lancet, 346, 1671, 10.1016/S0140-6736(95)92842-1 Jabs, 1989, Cytomegalovirus retinitis and acquired immunodeficiency syndrome, Arch Ophthalmol, 107, 75, 10.1001/archopht.1989.01070010077031 Jabs, 2004, Course of cytomegalovirus retinitis in the era of highly active antiretroviral therapy: 2. Second eye involvement and retinal detachment, Ophthalmology, 111, 2232, 10.1016/j.ophtha.2004.05.028 Bloom, 1988, The diagnosis of cytomegalovirus retinitis, Ann Intern Med, 109, 963, 10.7326/0003-4819-109-12-963 Henderly, 1991, Diagnosis and treatment of cytomegalovirus retinitis, J Acquir Immune Defic Syndr, 4, S6 Jabs, 1991, Retinal detachments in patients with cytomegalovirus retinitis, Arch Ophthalmol, 109, 794, 10.1001/archopht.1991.01080060058024 Kempen, 2003, Risk of vision loss in patients with cytomegalovirus retinitis and the acquired immunodeficiency syndrome, Arch Ophthalmol, 121, 466, 10.1001/archopht.121.4.466 Banker, 2008, Posterior segment manifestations of human immunodeficiency virus/acquired immune deficiency syndrome, Indian J Ophthalmol, 56, 377, 10.4103/0301-4738.42413 Price, 2001, Immune dysfunction and immune restoration disease in HIV patients given highly active antiretroviral therapy, J Clin Virol, 22, 279, 10.1016/S1386-6532(01)00200-1 Martin, 2002, A controlled trial of valganciclovir as induction therapy for cytomegalovirus retinitis, N Engl J Med, 346, 1119, 10.1056/NEJMoa011759 Visser, 2003, Retinitis in the developing world, Community Eye Health, 16, 38 Musch, 1997, Treatment of cytomegalovirus retinitis with a sustained-release ganciclovir implant. The Ganciclovir Implant Study Group, N Engl J Med, 337, 83, 10.1056/NEJM199707103370203 Holbrook, 2003, Visual loss in patients with cytomegalovirus retinitis and acquired immunodeficiency syndrome before widespread availability of highly active antiretroviral therapy, Arch Ophthalmol, 121, 99, 10.1001/archopht.121.1.99 Freeman, 1992, Surgical repair of rhegmatogenous retinal detachment in immunosuppressed patients with cytomegalovirus retinitis, Ophthalmology, 99, 466, 10.1016/S0161-6420(92)31976-1 Wilson J, Jungner G. Principles and practice of screening for disease. http://www.who.int/bulletin/volumes/86/4/07-050112BP.pdf. Geneva: WHO; 1968 [accessed 16 October 2010]. Wilson, 1971, Principles of screening for disease, Proc R Soc Med, 64, 1255 Wei, 2002, Prevalence of visual symptoms among patients with newly diagnosed cytomegalovirus retinitis, Retina, 22, 278, 10.1097/00006982-200206000-00004 Sandy, 1995, Screening for cytomegalovirus retinitis in HIV-positive and AIDS patients, QJM, 88, 899 Brodrick, 2003, To screen or not to screen, can symptoms answer the question: how efficient is routine screening for CMV retinitis in the HAART era?, Invest Ophthalmol Vis Sci, 44, 3128 Murthy, 2008, The socioeconomic impact of human immunodeficiency virus/acquired immune deficiency syndrome in India and its relevance to eye care, Indian J Ophthalmol, 56, 395, 10.4103/0301-4738.42416 Kaplan, 2009, Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America, MMWR Recomm Rep, 58, 1 Jabs, 2004, Course of cytomegalovirus retinitis in the era of highly active antiretroviral therapy: 1. Retinitis progression, Ophthalmology, 111, 10.1016/j.ophtha.2004.05.031 Leo S-W. Telemedicine screening for cytomegalovirus retinitis using digital photography; Poster 10. American Academy of Ophthalmology Annual Meeting. Anaheim, California; 2003. Mudvari, 2010, Ultra-wide-field imaging for cytomegalovirus retinitis, Ophthalmic Surg Lasers Imaging, 41, 311, 10.3928/15428877-20100430-03 Newsom, 2000, Screening for CMV retinitis using chromatic discrimination thresholds and achromatic contrast sensitivity, Br J Ophthalmol, 84, 877, 10.1136/bjo.84.8.877 Teich, 1996, Evaluation of a new self-screening chart for cytomegalovirus retinitis in patients with AIDS, J Acquir Immune Defic Syndr Hum Retrovirol, 13, 336, 10.1097/00042560-199612010-00006 Plummer, 1996, Effectiveness of entoptic perimetry for locating peripheral scotomas caused by cytomegalovirus retinitis, Arch Ophthalmol, 114, 828, 10.1001/archopht.1996.01100140042005 Gellrich, 1996, Pattern, flicker, and flash electroretinography in human immunodeficiency virus infection: a longitudinal study, Ger J Ophthalmol, 5, 16 Latkany, 1997, Electroretinographic and psychophysical findings during early and late stages of human immunodeficiency virus infection and cytomegalovirus retinitis, Ophthalmology, 104, 445, 10.1016/S0161-6420(97)30293-0 Gerard, 1997, Cytomegalovirus (CMV) viremia and the CD4+ lymphocyte count as predictors of CMV disease in patients infected with human immunodeficiency virus, Clin Infect Dis, 24, 836, 10.1093/clinids/24.5.836 Tufail, 1999, Quantitative cytomegalovirus DNA level in the blood and its relationship to cytomegalovirus retinitis in patients with acquired immune deficiency syndrome, Ophthalmology, 106, 133, 10.1016/S0161-6420(99)90015-5 Dodt, 1997, Development of cytomegalovirus (CMV) disease may be predicted in HIV-infected patients by CMV polymerase chain reaction and the antigenemia test, AIDS, 11, F21, 10.1097/00002030-199703110-00001 Fezza, 2001, Quantitative CMV antigenemia correlated with ophthalmoscopic screening for CMV retinitis in AIDS patients, Ophthalmic Surg Lasers, 32, 81, 10.3928/1542-8877-20010101-17 Bowen, 1997, Cytomegalovirus (CMV) viraemia detected by polymerase chain reaction identifies a group of HIV-positive patients at high risk of CMV disease, AIDS, 11, 889, 10.1097/00002030-199707000-00008 Gellrich, 1996, Clinical utility of cytomegalovirus urine cultures for ophthalmic care in patients with HIV, Br J Ophthalmol, 80, 818, 10.1136/bjo.80.9.818 Sommer, 2007, Global access to eye care, Arch Ophthalmol, 125, 399, 10.1001/archopht.125.3.399 Chandra, 2008, Global blindness: VISION 2020: the right to sight, Arch Ophthalmol, 126, 1457, 10.1001/archopht.126.10.1457 Tun, 2011, CMV retinitis screening and treatment in a resource-poor setting: three-year experience from a primary care HIV/AIDS programme in Myanmar, J Int AIDS Soc, 14, 41, 10.1186/1758-2652-14-41 Kuper, 2006, Economic evaluation for ophthalmologists, Ophthalmic Epidemiol, 13, 393, 10.1080/09286580600760539 Scotland, 2007, Cost-effectiveness of implementing automated grading within the national screening programme for diabetic retinopathy in Scotland, Br J Ophthalmol, 91, 1518, 10.1136/bjo.2007.120972 Skalet, 2008, Telemedicine screening for retinopathy of prematurity in developing countries using digital retinal images: a feasibility project, J AAPOS, 12, 252, 10.1016/j.jaapos.2007.11.009 Constable, 2000, Fred Hollows lecture: digital screening for eye disease, Clin Experiment Ophthalmol, 28, 129, 10.1046/j.1442-9071.2000.00309.x Fleming, 2010, Automated grading for diabetic retinopathy: a large-scale audit using arbitration by clinical experts, Br J Ophthalmol, 94, 1606, 10.1136/bjo.2009.176784 Fleming, 2007, Automated detection of exudates for diabetic retinopathy screening, Phys Med Biol, 52, 7385, 10.1088/0031-9155/52/24/012 Larsen, 2003, Automated detection of diabetic retinopathy in a fundus photographic screening population, Invest Ophthalmol Vis Sci, 44, 767, 10.1167/iovs.02-0417 Philip, 2007, The efficacy of automated “disease/no disease” grading for diabetic retinopathy in a systematic screening programme, Br J Ophthalmol, 91, 1512, 10.1136/bjo.2007.119453 Holland, 2010, Development of pattern recognition software for automated computer detection of AIDS-related cytomegalovirus retinitis on digital fundus photographs, Invest Ophthalmol Vis Sci, 51, 4852 Lawn, 2009, Changing mortality risk associated with CD4 cell response to antiretroviral therapy in South Africa, AIDS, 23, 335, 10.1097/QAD.0b013e328321823f Lalonde, 2004, Canadian consensus guidelines for the management of cytomegalovirus disease in HIV/AIDS, Can J Infect Dis Med Microbiol, 15, 327, 10.1155/2004/369390 NACO. Guidelines for prevention and management of common opportunistic infections. New Delhi:National AIDS Control Organisation; 2007. Wohl, 2000, Routine ophthalmologic screening for cytomegalovirus retinitis in patients with AIDS, J Acquir Immune DeficSyndr, 23, 438, 10.1097/00126334-200004150-00013 Foscarnet-Ganciclovir Cytomegalovirus Retinitis Trial: 5. Clinical features of cytomegalovirus retinitis at diagnosis. Studies of ocular complications of AIDS Research Group in collaboration with the AIDS Clinical Trials Group.Am J Ophthalmol 1997;124:141–57. Janssens B, Heiden D, Sarin S, et al. Cytomegalovirus retinitis is an important problem that is being missed in HIV-positive individuals attending routine clinics in Cambodia: is there a need to introduce routine CMV screening. XVI International AIDS Conference: 2006; Toronto, Canada; 2006.