Cytokines sing the blues: inflammation and the pathogenesis of depression

Trends in Immunology - Tập 27 Số 1 - Trang 24-31 - 2006
Charles L. Raison1, Lucile Capuron1, Andrew H. Miller1
1Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Suite 4000, Atlanta, GA 30322, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Herbert, 1993, Depression and immunity: a meta-analytic review, Psychol. Bull., 113, 472, 10.1037/0033-2909.113.3.472

Wellen, 2005, Inflammation, stress, and diabetes, J. Clin. Invest., 115, 1111, 10.1172/JCI200525102

Willerson, J.T. and Ridker, P.M. (2004) Inflammation as a cardiovascular risk factor. Circulation 109 (21, Suppl 1), II2–10

Li, 2005, Inflammation-associated cancer: NF-kappaB is the lynchpin, Trends Immunol, 26, 318, 10.1016/j.it.2005.04.003

Evans, 2005, Mood disorders in the medically ill: scientific review and recommendations, Biol. Psychiatry, 58, 175, 10.1016/j.biopsych.2005.05.001

Alesci, 2005, Major depression is associated with significant diurnal elevations in plasma interleukin-6 levels, a shift of its circadian rhythm, and loss of physiological complexity in its secretion: clinical implications, J. Clin. Endocrinol. Metab., 90, 2522, 10.1210/jc.2004-1667

Miller, 2002, Clinical depression and inflammatory risk markers for coronary heart disease, Am. J. Cardiol., 90, 1279, 10.1016/S0002-9149(02)02863-1

Bouhuys, 2004, Potential psychosocial mechanisms linking depression to immune function in elderly subjects, Psychiatry Res., 127, 237, 10.1016/j.psychres.2004.05.001

Musselman, 2001, Higher than normal plasma interleukin-6 concentrations in cancer patients with depression: preliminary findings, Am. J. Psychiatry, 158, 1252, 10.1176/appi.ajp.158.8.1252

Kahl, 2005, Bone mineral density, markers of bone turnover, and cytokines in young women with borderline personality disorder with and without comorbid major depressive disorder, Am. J. Psychiatry, 162, 168, 10.1176/appi.ajp.162.1.168

Tiemeier, 2003, Inflammatory proteins and depression in the elderly, Epidemiology, 14, 103, 10.1097/00001648-200301000-00025

Schlatter, 2004, Monocytic parameters in patients with dysthymia versus major depression, J. Affect. Disord., 78, 243, 10.1016/S0165-0327(02)00316-6

Ford, 2004, Depression and C-reactive protein in US adults, Arch. Intern. Med., 164, 1010, 10.1001/archinte.164.9.1010

Danner, 2003, Association between depression and elevated C-reactive protein, Psychosom. Med., 65, 347, 10.1097/01.PSY.0000041542.29808.01

Maes, 1999, Major depression and activation of the inflammatory response system, Adv. Exp. Med. Biol., 461, 25, 10.1007/978-0-585-37970-8_2

Levine, 1999, Cerebrospinal cytokine levels in patients with acute depression, Neuropsychobiology, 40, 171, 10.1159/000026615

Lanquillon, 2000, Cytokine production and treatment response in major depressive disorder, Neuropsychopharmacology, 22, 370, 10.1016/S0893-133X(99)00134-7

Rajagopalan, 2001, Abnormal brachial artery flow-mediated vasodilation in young adults with major depression, Am. J. Cardiol., 88, 196, 10.1016/S0002-9149(01)01623-X

Sluzewska, 1995, Interleukin-6 serum levels in depressed patients before and after treatment with fluoxetine, Ann. N. Y. Acad. Sci., 762, 474, 10.1111/j.1749-6632.1995.tb32372.x

Maes, 1997, Increased serum IL-6 and IL-1 receptor antagonist concentrations in major depression and treatment resistant depression, Cytokine, 9, 853, 10.1006/cyto.1997.0238

Mikova, 2001, Increased serum tumor necrosis factor alpha concentrations in major depression and multiple sclerosis, Eur. Neuropsychopharmacol., 11, 203, 10.1016/S0924-977X(01)00081-5

Sluzewska, 1997, Changes in acute-phase proteins during lithium potentiation of antidepressants in refractory depression, Neuropsychobiology, 35, 123, 10.1159/000119332

Tuglu, 2003, Increased serum tumor necrosis factor-alpha levels and treatment response in major depressive disorder, Psychopharmacology (Berl.), 170, 429, 10.1007/s00213-003-1566-z

Hestad, 2003, Raised plasma levels of tumor necrosis factor alpha in patients with depression, J. ECT, 19, 183, 10.1097/00124509-200312000-00002

Owen, 2001, Raised levels of plasma interleukin-1beta in major and postviral depression, Acta Psychiatr. Scand., 103, 226, 10.1034/j.1600-0447.2001.00162.x

Thomas, 2005, Increase in interleukin-1beta in late-life depression, Am. J. Psychiatry, 162, 175, 10.1176/appi.ajp.162.1.175

Yu, 2003, Association study of the interleukin-1 beta (C-511T) genetic polymorphism with major depressive disorder, associated symptomatology, and antidepressant response, Neuropsychopharmacology, 28, 1182, 10.1038/sj.npp.1300172

Jun, 2003, Possible association between -G308A tumour necrosis factor-alpha gene polymorphism and major depressive disorder in the Korean population, Psychiatr. Genet., 13, 179, 10.1097/00041444-200309000-00008

Suarez, 2004, Enhanced expression of cytokines and chemokines by blood monocytes to in vitro lipopolysaccharide stimulation are associated with hostility and severity of depressive symptoms in healthy women, Psychoneuroendocrinology, 29, 1119, 10.1016/j.psyneuen.2004.01.002

van der Ven, 2003, Herpes viruses, cytokines, and altered hemostasis in vital exhaustion, Psychosom. Med., 65, 194, 10.1097/01.PSY.0000058378.50240.80

Irwin, 2004, Nocturnal proinflammatory cytokine-associated sleep disturbances in abstinent African American alcoholics, Brain Behav. Immun., 18, 349, 10.1016/j.bbi.2004.02.001

Suarez, 2002, The relation of aggression, hostility, and anger to lipopolysaccharide-stimulated tumor necrosis factor (TNF)-alpha by blood monocytes from normal men, Brain Behav. Immun., 16, 675, 10.1016/S0889-1591(02)00019-3

Lesperance, 2004, The association between major depression and levels of soluble intercellular adhesion molecule 1, interleukin-6, and C-reactive protein in patients with recent acute coronary syndromes, Am. J. Psychiatry, 161, 271, 10.1176/appi.ajp.161.2.271

Miller, 2005, Relation of depressive symptoms to C-reactive protein and pathogen burden (cytomegalovirus, herpes simplex virus, Epstein-Barr virus) in patients with earlier acute coronary syndromes, Am. J. Cardiol., 95, 317, 10.1016/j.amjcard.2004.09.026

Bower, 2002, Fatigue and proinflammatory cytokine activity in breast cancer survivors, Psychosom. Med., 64, 604, 10.1097/00006842-200207000-00010

Meyers, 2005, Cognitive impairment, fatigue, and cytokine levels in patients with acute myelogenous leukemia or myelodysplastic syndrome, Cancer, 104, 788, 10.1002/cncr.21234

Haack, 1999, Plasma levels of cytokines and soluble cytokine receptors in psychiatric patients upon hospital admission: effects of confounding factors and diagnosis, J. Psychiatr. Res., 33, 407, 10.1016/S0022-3956(99)00021-7

Steptoe, 2003, Lack of association between depressive symptoms and markers of immune and vascular inflammation in middle-aged men and women, Psychol. Med., 33, 667, 10.1017/S0033291702007250

Miller, 2003, Pathways linking depression, adiposity, and inflammatory markers in healthy young adults, Brain Behav. Immun., 17, 276, 10.1016/S0889-1591(03)00057-6

Motivala, 2005, Inflammatory markers and sleep disturbance in major depression, Psychosom. Med., 67, 187, 10.1097/01.psy.0000149259.72488.09

Szabo, 2004, Neurotransmitters, receptors, signal transduction, and second messengers in psychiatric disorders, 3

Owens, 1991, Physiology and pharmacology of corticotropin-releasing factor, Pharmacol. Rev., 43, 425

Raison, 2003, When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders, Am. J. Psychiatry, 160, 1554, 10.1176/appi.ajp.160.9.1554

Pariante, 2001, Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment, Biol. Psychiatry, 49, 391, 10.1016/S0006-3223(00)01088-X

Martinot, 2001, Decreased presynaptic dopamine function in the left caudate of depressed patients with affective flattening and psychomotor retardation, Am. J. Psychiatry, 158, 314, 10.1176/appi.ajp.158.2.314

Drevets, 2001, Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders, Curr. Opin. Neurobiol., 11, 240, 10.1016/S0959-4388(00)00203-8

Duman, 2004, Depression: a case of neuronal life and death?, Biol. Psychiatry, 56, 140, 10.1016/j.biopsych.2004.02.033

Maier, 1998, Cytokines for psychologists: implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition, Psychol. Rev., 105, 83, 10.1037/0033-295X.105.1.83

Dantzer, 2004, Cytokine-induced sickness behaviour: a neuroimmune response to activation of innate immunity, Eur. J. Pharmacol., 500, 399, 10.1016/j.ejphar.2004.07.040

Gao, 2002, Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease, J. Neurochem., 81, 1285, 10.1046/j.1471-4159.2002.00928.x

Dunn, 1999, Effects of cytokines on cerebral neurotransmission. Comparison with the effects of stress, Adv. Exp. Med. Biol., 461, 117, 10.1007/978-0-585-37970-8_8

Besedovsky, 1996, Immune-neuro-endocrine interactions: facts and hypotheses, Endocr. Rev., 17, 64, 10.1210/edrv-17-1-64

Silverman, 2005, Immune modulation of the hypothalamic-pituitary-adrenal (HPA) axis during viral infection, Viral Immunol., 18, 41, 10.1089/vim.2005.18.41

Capuron, 2004, Cytokines and psychopathology: lessons from interferon-alpha, Biol. Psychiatry, 56, 819, 10.1016/j.biopsych.2004.02.009

Wang, 2004, Interleukin-1 alpha-induced activation of p38 mitogen-activated kinase inhibits glucocorticoid receptor function, Mol. Psychiatry, 9, 65, 10.1038/sj.mp.4001339

McKay, 1999, Molecular control of immune/inflammatory responses: interactions between nuclear factor-kappa B and steroid receptor-signaling pathways, Endocr. Rev., 20, 435, 10.1210/er.20.4.435

Zhu, 2005, p38 MAPK activation elevates serotonin transport activity via a trafficking-independent, protein phosphatase 2A-dependent process, J. Biol. Chem., 280, 15649, 10.1074/jbc.M410858200

Nadjar, A. et al. Inactivation of the cerebral NFkappaB pathway inhibits interleukin-1beta-induced sickness behavior and c-Fos expression in various brain nuclei. Neuropsychopharmacology (in press)

Lu, 2004, Gene regulation and DNA damage in the ageing human brain, Nature, 429, 883, 10.1038/nature02661

Madrigal, 2002, The increase in TNF-alpha levels is implicated in NF-kappaB activation and inducible nitric oxide synthase expression in brain cortex after immobilization stress, Neuropsychopharmacology, 26, 155, 10.1016/S0893-133X(01)00292-5

Musselman, 2001, Paroxetine for the prevention of depression induced by high-dose interferon alfa, N. Engl. J. Med., 344, 961, 10.1056/NEJM200103293441303

Capuron, 2002, Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy, Mol. Psychiatry, 7, 468, 10.1038/sj.mp.4000995

Capuron, 2003, Association of exaggerated HPA axis response to the initial injection of interferon-alpha with development of depression during interferon-alpha therapy, Am. J. Psychiatry, 160, 1342, 10.1176/appi.ajp.160.7.1342

Juengling, 2000, Prefrontal cortical hypometabolism during low-dose interferon alpha treatment, Psychopharmacology (Berl.), 152, 383, 10.1007/s002130000549

Capuron, 2005, Anterior cingulate activation and error processing during interferon-alpha treatment, Biol. Psychiatry, 58, 190, 10.1016/j.biopsych.2005.03.033

Kendler, 2000, Stressful life events and previous episodes in the etiology of major depression in women: an evaluation of the ‘kindling’ hypothesis, Am. J. Psychiatry, 157, 1243, 10.1176/appi.ajp.157.8.1243

O'Connor, 2003, Peripheral and central proinflammatory cytokine response to a severe acute stressor, Brain Res., 991, 123, 10.1016/j.brainres.2003.08.006

Pugh, 1999, Role of interleukin-1 beta in impairment of contextual fear conditioning caused by social isolation, Behav. Brain Res., 106, 109, 10.1016/S0166-4328(99)00098-4

Barrientos, 2003, Brain-derived neurotrophic factor mRNA downregulation produced by social isolation is blocked by intrahippocampal interleukin-1 receptor antagonist, Neuroscience, 121, 847, 10.1016/S0306-4522(03)00564-5

Goebel, 2000, Interleukin-6 and tumor necrosis factor-alpha production after acute psychological stress, exercise, and infused isoproterenol: differential effects and pathways, Psychosom. Med., 62, 591, 10.1097/00006842-200007000-00019

Deinzer, 2004, Acute stress effects on local Il-1beta responses to pathogens in a human in vivo model, Brain Behav. Immun., 18, 458, 10.1016/j.bbi.2003.11.008

Maes, 1998, The effects of psychological stress on humans: increased production of pro-inflammatory cytokines and a Th1-like response in stress-induced anxiety, Cytokine, 10, 313, 10.1006/cyto.1997.0290

Bierhaus, 2003, A mechanism converting psychosocial stress into mononuclear cell activation, Proc. Natl. Acad. Sci. U. S. A., 100, 1920, 10.1073/pnas.0438019100

Moraska, 2002, Elevated IL-1beta contributes to antibody suppression produced by stress, J. Appl. Physiol., 93, 207, 10.1152/japplphysiol.01151.2001

Murray, 2000, Chronic beta-adrenergic stimulation induces myocardial proinflammatory cytokine expression, Circulation, 101, 2338, 10.1161/01.CIR.101.20.2338

Mayer, 2005, Functional improvement in heart failure patients treated with beta-blockers is associated with a decline of cytokine levels, Int. J. Cardiol., 103, 182, 10.1016/j.ijcard.2004.08.053

Pavlov, 2005, The cholinergic anti-inflammatory pathway, Brain Behav. Immun., 19, 493, 10.1016/j.bbi.2005.03.015

Janszky, 2004, Inflammatory markers and heart rate variability in women with coronary heart disease, J. Intern. Med., 256, 421, 10.1111/j.1365-2796.2004.01403.x

Kim, 2005, Depressive symptoms and heart rate variability in postmenopausal women, Arch. Intern. Med., 165, 1239, 10.1001/archinte.165.11.1239

Avitsur, 2001, Social stress induces glucocorticoid resistance in subordinate animals, Horm. Behav., 39, 247, 10.1006/hbeh.2001.1653

Kenis, 2002, Effects of antidepressants on the production of cytokines, Int. J. Neuropsychopharmacol., 5, 401, 10.1017/S1461145702003164

Reynolds, 2004, Brain-derived tumor necrosis factor-alpha and its involvement in noradrenergic neuron functioning involved in the mechanism of action of an antidepressant, J. Pharmacol. Exp. Ther., 310, 1216, 10.1124/jpet.104.067835

Frommberger, 1997, Interleukin-6-(IL-6) plasma levels in depression and schizophrenia: comparison between the acute state and after remission, Eur. Arch. Psychiatry Clin. Neurosci., 247, 228, 10.1007/BF02900219

Benedetti, 2002, Interleukine-6 serum levels correlate with response to antidepressant sleep deprivation and sleep phase advance, Prog. Neuropsychopharmacol. Biol. Psychiatry, 26, 1167, 10.1016/S0278-5846(02)00255-5

Capuron, 2002, Neurobehavioral effects of interferon-alpha in cancer patients: phenomenology and paroxetine responsiveness of symptom dimensions, Neuropsychopharmacology, 26, 643, 10.1016/S0893-133X(01)00407-9

Morrow, 2003, Differential effects of paroxetine on fatigue and depression: a randomized, double-blind trial from the University of Rochester Cancer Center Community Clinical Oncology Program, J. Clin. Oncol., 21, 4635, 10.1200/JCO.2003.04.070

Greco, 2004, The outcome of physical symptoms with treatment of depression, J. Gen. Intern. Med., 19, 813, 10.1111/j.1525-1497.2004.30531.x

Maier, 1995, Intracerebroventricular interleukin-1 receptor antagonist blocks the enhancement of fear conditioning and interference with escape produced by inescapable shock, Brain Res., 695, 279, 10.1016/0006-8993(95)00930-O

Lichtenstein, 2002, Infliximab improves quality of life in patients with Crohn's disease, Inflamm. Bowel Dis., 8, 237, 10.1097/00054725-200207000-00001

Mathias, 2000, Health-related quality of life and functional status of patients with rheumatoid arthritis randomly assigned to receive etanercept or placebo, Clin. Therap., 22, 128, 10.1016/S0149-2918(00)87984-9

2000