Nội dung được dịch bởi AI, chỉ mang tính chất tham khảo
Mức độ cytokine và mối quan hệ của chúng với tình trạng ký sinh trùng và bệnh cơ tim ở những người mắc bệnh Chagas tại Tây Ban Nha. Một nghiên cứu quan sát có triển vọng
Tóm tắt
Các mạng lưới điều hòa miễn dịch có thể đóng vai trò trong việc kiểm soát tình trạng ký sinh trùng trong giai đoạn mạn tính của bệnh Chagas ở người. Mục tiêu là mô tả hồ sơ cytokine trong huyết thanh của Trypanosoma cruzi ở những bệnh nhân bị nhiễm mạn tính và đánh giá mối quan hệ của nó với tình trạng ký sinh trùng và bệnh cơ tim Chagas. Nghiên cứu quan sát có triển vọng này bao gồm các bệnh nhân trưởng thành mắc bệnh Chagas mạn tính. Dữ liệu nhân khẩu học và lâm sàng được thu thập, và mẫu máu ngoại vi được sử dụng để thực hiện phản ứng chuỗi polymerase theo thời gian thực (RT-PCR) đối với T. cruzi và xác định hồ sơ cytokine trong huyết thanh. Năm mươi tám bệnh nhân đã được đưa vào nghiên cứu; 17 (29,3%) có kết quả RT-PCR dương tính. Nhóm này có nồng độ TNF-α trung vị cao hơn (p = 0,003), IL-6 (p = 0,021), IL-4 (p = 0,031), IL-1β (p = 0,036) và IL-17A (p = 0,043) so với những người có kết quả RT-PCR âm tính. Những bệnh nhân có biểu hiện tim có nồng độ IL-5 trung vị cao hơn (p = 0,016) so với những người không bị. Những kết quả này khẳng định vai trò quan trọng mà các cytokine đóng trong bệnh nhân Chagas có tình trạng ký sinh trùng và có biểu hiện tim.
Từ khóa
#bệnh Chagas #cytokine #Trypanosoma cruzi #cơ tim #RT-PCRTài liệu tham khảo
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