Mức độ cytokine và mối quan hệ của chúng với tình trạng ký sinh trùng và bệnh cơ tim ở những người mắc bệnh Chagas tại Tây Ban Nha. Một nghiên cứu quan sát có triển vọng

Parasitology Research - Tập 123 - Trang 1-10 - 2023
Jose-Manuel Ramos-Rincon1,2, Diego Torrús-Tendero3,4, Hilarion García-Morante5,6, Adelina Gimeno-Gascón7,8, Francisco Marco9, Concepción Gil-Anguita10, Philip Wikman-Jorgensen6,11, Ana Lucas-Dato5,6, Juan-Carlos Rodriguez-Diaz12,13, Concepción Amador10, Jara Llenas-García2,5,6
1Internal Medicine Department, Dr. Balmis General University Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain
2Clinical Medicine Department, Miguel Hernández University of Elche, Alicante, Spain
3Reference Unit of Imported Diseases and International Health & Infectious Diseases Unit, Dr. Balmis General University Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain
4Parasitology Area, Miguel Hernández University of Elche, Alicante, Spain
5Internal Medicine Department, Vega Baja Hospital, Alicante, Spain
6Foundation for the Promotion of Health and Biomedical Research of the Valencia Region (FISABIO), Valencia, Spain
7Clinical Unit of Infectious Diseases, Microbiology, and Parasitology, Virgen del Rocío University Hospital, Seville, Spain
8Clinical and Molecular Microbiology Research Group, Institute of Biomedicine of Seville (IBiS), Seville, Spain
9Immunology Department, Dr. Balmis General University Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain
10Internal Medicine Department, Marina Baixa Hospital, Alicante, Spain
11Internal Medicine Department, General University Hospital of Elda, Alicante, Spain
12Microbiology Department, Dr. Balmis General University Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain
13Microbiology Department, Miguel Hernández University of Elche, Elche, Spain

Tóm tắt

Các mạng lưới điều hòa miễn dịch có thể đóng vai trò trong việc kiểm soát tình trạng ký sinh trùng trong giai đoạn mạn tính của bệnh Chagas ở người. Mục tiêu là mô tả hồ sơ cytokine trong huyết thanh của Trypanosoma cruzi ở những bệnh nhân bị nhiễm mạn tính và đánh giá mối quan hệ của nó với tình trạng ký sinh trùng và bệnh cơ tim Chagas. Nghiên cứu quan sát có triển vọng này bao gồm các bệnh nhân trưởng thành mắc bệnh Chagas mạn tính. Dữ liệu nhân khẩu học và lâm sàng được thu thập, và mẫu máu ngoại vi được sử dụng để thực hiện phản ứng chuỗi polymerase theo thời gian thực (RT-PCR) đối với T. cruzi và xác định hồ sơ cytokine trong huyết thanh. Năm mươi tám bệnh nhân đã được đưa vào nghiên cứu; 17 (29,3%) có kết quả RT-PCR dương tính. Nhóm này có nồng độ TNF-α trung vị cao hơn (p = 0,003), IL-6 (p = 0,021), IL-4 (p = 0,031), IL-1β (p = 0,036) và IL-17A (p = 0,043) so với những người có kết quả RT-PCR âm tính. Những bệnh nhân có biểu hiện tim có nồng độ IL-5 trung vị cao hơn (p = 0,016) so với những người không bị. Những kết quả này khẳng định vai trò quan trọng mà các cytokine đóng trong bệnh nhân Chagas có tình trạng ký sinh trùng và có biểu hiện tim.

Từ khóa

#bệnh Chagas #cytokine #Trypanosoma cruzi #cơ tim #RT-PCR

Tài liệu tham khảo

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