Cytokine production in patients with papillary thyroid cancer and associated autoimmune Hashimoto thyroiditis

Springer Science and Business Media LLC - Tập 64 - Trang 1011-1019 - 2015
Snezana Zivancevic-Simonovic1, Olgica Mihaljevic1, Ivana Majstorovic2, Suzana Popovic1, Slavica Markovic1,3, Olivera Milosevic-Djordjevic1, Zorica Jovanovic1, Ljiljana Mijatovic-Teodorovic1,3, Dusan Mihajlovic2, Miodrag Colic2
1Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
2Institute for Medical Research, Military Medical Academy, Belgrade, Serbia
3Department of Nuclear Medicine, Clinical Center Kragujevac, Kragujevac, Serbia

Tóm tắt

Hashimoto thyroiditis (HT) is the most frequent thyroid autoimmune disease, while papillary thyroid cancer (PTC) is one of the most common endocrine malignancies. A few patients with HT also develop PTC. The aim of this study was to analyze cytokine profiles in patients with PTC accompanied with autoimmune HT in comparison with those in patients with PTC alone or HT alone and healthy subjects. Cytokine levels were determined in supernatants obtained from phytohemagglutinin (PHA)-stimulated whole blood cultures in vitro. The concentrations of selected cytokines: Th1—interferon gamma (IFN-γ); Th2—interleukin 4 (IL-4), interleukin 5 (IL-5), interleukin 6 (IL-6), interleukin 10 (IL-10) and interleukin 13 (IL-13); Th9—interleukin 9 (IL-9); and Th17—interleukin 17 (IL-17A) were measured using multiplex cytokine detection systems for human Th1/Th2/Th9/Th17/Th22. We found that PTC patients with HT produced significantly higher concentrations of IL-4, IL-6, IL-9, IL-13 and IFN-γ than PTC patients without HT. In conclusion, autoimmune HT affects the cytokine profile of patients with PTC by stimulating secretion of Th1/Th2/Th9 types of cytokines. Th1/Th2 cytokine ratios in PTC patients with associated autoimmune HT indicate a marked shift toward Th2 immunity.

Tài liệu tham khảo

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