Cytokine and chemokine responses in serum and brain after single and repeated injections of lipopolysaccharide: Multiplex quantification with path analysis

Abazyan, 2010, Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology, Biol. Psychiatry, 68, 1172, 10.1016/j.biopsych.2010.09.022

Abbott, 2010, Structure and function of the blood–brain barrier, Neurobiol. Dis., 37, 13, 10.1016/j.nbd.2009.07.030

Banks, 2005, Blood–brain barrier transport of cytokines: a mechanism for neuropathology, Curr. Pharm. Des., 11, 973, 10.2174/1381612053381684

Banks, 2008, The blood–brain barrier as a cause of obesity, Curr. Pharm. Des., 14, 1606, 10.2174/138161208784705496

Banks, 2010, The blood–brain barrier and immune function and dysfunction, Neurobiol. Dis., 37, 26, 10.1016/j.nbd.2009.07.031

Banks, W.A., Robinson, S.M., 2009. Minimal penetration of lipopolysaccharide across the murine blood–brain barrier. Brain Behav. Immun.

Banks, 2010, Minimal penetration of lipopolysaccharide across the murine blood–brain barrier, Brain Behav. Immun., 24, 102, 10.1016/j.bbi.2009.09.001

Banks, 1991, Human interleukin (IL) 1 alpha, murine IL-1 alpha and murine IL-1 beta are transported from blood to brain in the mouse by a shared saturable mechanism, J. Pharmacol. Exp. Ther., 259, 988

Banks, 1994, Penetration of interleukin-6 across the murine blood–brain barrier, Neurosci. Lett., 179, 53, 10.1016/0304-3940(94)90933-4

Banks, 1999, Adsorptive endocytosis of HIV-1gp120 by blood–brain barrier is enhanced by lipopolysaccharide, Exp. Neurol., 156, 165, 10.1006/exnr.1998.7011

Banks, 2006, The blood–brain barrier in neuroAIDS, Curr. HIV Res., 4, 259, 10.2174/157016206777709447

Baron, 1986, The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations, J. Pers. Soc. Psychol., 51, 1173, 10.1037/0022-3514.51.6.1173

Baykal, 1999, Epinephrine and endotoxin tolerance differentially modulate serum cytokine levels to high-dose lipopolysaccharide challenge in a murine model, Surgery, 125, 403, 10.1016/S0039-6060(99)70008-5

Blatteis, 1992, Role of the OVLT in the febrile response to circulating pyrogens, Prog. Brain Res., 91, 409, 10.1016/S0079-6123(08)62360-2

Brown, 2010, Production of proinflammatory cytokines and chemokines during neuroinflammation: novel roles for estrogen receptors alpha and beta, Endocrinology, 151, 4916, 10.1210/en.2010-0371

Castaneda, 2010, Ghrelin in the regulation of body weight and metabolism, Front. Neuroendocrinol., 31, 44, 10.1016/j.yfrne.2009.10.008

Cavaillon, 2003, Endotoxin tolerance. Is there a clinical relevance?, J. Endotoxin Res., 9, 101, 10.1179/096805103125001487

Chakravarty, 2005, Toll-like receptor 4 on nonhematopoietic cells sustains CNS inflammation during endotoxemia, independent of systemic cytokines, J. Neurosci., 25, 1788, 10.1523/JNEUROSCI.4268-04.2005

Chen, 2005, Differential expression of cytokines in the brain and serum during endotoxin tolerance, J. Neuroimmunol., 163, 53, 10.1016/j.jneuroim.2005.02.012

Combrinck, 2002, Peripheral infection evokes exaggerated sickness behaviour in pre-clinical murine prion disease, Neuroscience, 112, 7, 10.1016/S0306-4522(02)00030-1

Conti, 2004, Cytokines and fever, Front. Biosci., 9, 1433, 10.2741/1341

Craft, 2009, The role of metabolic disorders in Alzheimer disease and vascular dementia: two roads converged, Arch Neurol., 66, 300, 10.1001/archneurol.2009.27

Datta, 2008, Lipopolysaccharide-induced increases in cytokines in discrete mouse brain regions are detectable using Luminex xMAP technology, J. Neurosci. Methods, 175, 119, 10.1016/j.jneumeth.2008.08.007

del Rey, 2009, Re-exposure to endotoxin induces differential cytokine gene expression in the rat hypothalamus and spleen, Brain Behav. Immun., 23, 776, 10.1016/j.bbi.2009.02.009

Erroi, 1993, Differential regulation of cytokine production in lipopolysaccharide tolerance in mice, Infect Immun., 61, 4356, 10.1128/IAI.61.10.4356-4359.1993

Fox, 2005, Minocycline confers early but transient protection in the immature brain following focal cerebral ischemia-reperfusion, J. Cereb. Blood Flow Metab., 25, 1138, 10.1038/sj.jcbfm.9600121

Goehler, 1999, Interleukin-1beta in immune cells of the abdominal vagus nerve: a link between the immune and nervous systems?, J. Neurosci., 19, 2799, 10.1523/JNEUROSCI.19-07-02799.1999

Gutierrez, 1993, Murine tumor necrosis factor alpha is transported from blood to brain in the mouse, J. Neuroimmunol., 47, 169, 10.1016/0165-5728(93)90027-V

Horani, 2003, Effect of diabetes on the blood brain barrier, Curr. Pharm. Des., 9, 833, 10.2174/1381612033455314

Jaeger, 2009, Lipopolysaccharide alters the blood–brain barrier transport of amyloid beta protein: a mechanism for inflammation in the progression of Alzheimer’s disease, Brain Behav. Immun., 23, 507, 10.1016/j.bbi.2009.01.017

Jin, 2011, Impact of p-glycoprotein inhibition and lipopolysaccharide administration on blood–brain barrier transport of colistin in mice, Antimicrob. Agents Chemother., 55, 502, 10.1128/AAC.01273-10

Kelley, 2003, Cytokine-induced sickness behavior, Brain Behav. Immun., 17, S112, 10.1016/S0889-1591(02)00077-6

Komaki, 1992, Effect of intravenous injection of IL-1 beta on PGE2 levels in several brain areas as determined by microdialysis, Am. J. Physiol., 262, E246

Lynch, 2008, Opiate modulation of IL-1alpha, IL-2, and TNF-alpha transport across the blood–brain barrier, Brain Behav. Immun., 22, 1096, 10.1016/j.bbi.2008.04.004

Marcondes, 2007, Enrichment and persistence of virus-specific CTL in the brain of simian immunodeficiency virus-infected monkeys is associated with a unique cytokine environment, J. Immunol., 178, 5812, 10.4049/jimmunol.178.9.5812

Moro, 2003, Expression and function of tumour necrosis factor-alpha-converting enzyme in the central nervous system, Neurosignals, 12, 53, 10.1159/000071814

Mrak, 2001, Interleukin-1, neuroinflammation, and Alzheimer’s disease, Neurobiol. Aging, 22, 903, 10.1016/S0197-4580(01)00287-1

Nonaka, 2004, Effects of lipopolysaccharide on leptin transport across the blood–brain barrier, Brain Res., 1016, 58, 10.1016/j.brainres.2004.04.066

Nonaka, 2005, Effect of lipopolysaccharide on the transport of pituitary adenylate cyclase activating polypeptide across the blood–brain barrier, Exp. Neurol., 191, 137, 10.1016/j.expneurol.2004.09.013

O’Connor, 2008, Regulation of IGF-I function by proinflammatory cytokines: at the interface of immunology and endocrinology, Cell Immunol., 252, 91, 10.1016/j.cellimm.2007.09.010

Opal, 2000, Anti-inflammatory cytokines, Chest, 117, 1162, 10.1378/chest.117.4.1162

Osburg, 2002, Effect of endotoxin on expression of TNF receptors and transport of TNF-alpha at the blood–brain barrier of the rat, Am. J. Physiol. Endocrinol. Metab., 283, E899, 10.1152/ajpendo.00436.2001

Pan, 1997, Blood–brain barrier permeability to ebiratide and TNF in acute spinal cord injury, Exp. Neurol., 146, 367, 10.1006/exnr.1997.6533

Pan, 2008, Neuroinflammation facilitates LIF entry into brain: role of TNF, Am. J. Physiol. Cell Physiol., 294, C1436, 10.1152/ajpcell.00489.2007

Qin, 2007, Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration, Glia, 55, 453, 10.1002/glia.20467

Reale, 2009, Peripheral chemo-cytokine profiles in Alzheimer’s and Parkinson’s diseases, Mini Rev. Med. Chem., 9, 1229, 10.2174/138955709789055199

Roth, 2001, Fever induction pathways: evidence from responses to systemic or local cytokine formation, Braz. J. Med. Biol. Res., 34, 301, 10.1590/S0100-879X2001000300003

Stamou, 2010, Posttranscriptional regulation of TNF mRNA: a paradigm of signal-dependent mRNA utilization and its relevance to pathology, Curr. Dir. Autoimmun., 11, 61, 10.1159/000289197

Stefani, 2009, Cholesterol in Alzheimer’s disease: unresolved questions, Curr. Alzheimer Res., 6, 15, 10.2174/156720509787313899

Steiner, 2006, Bacterial lipopolysaccharide fever is initiated via Toll-like receptor 4 on hematopoietic cells, Blood, 107, 4000, 10.1182/blood-2005-11-4743

Tonelli, 2005, Tumor necrosis factor alpha, interleukin-1 beta, interleukin-6 and major histocompatibility complex molecules in the normal brain and after peripheral immune challenge, Neurol. Res., 27, 679, 10.1179/016164105X49463

Verma, 2006, Release of cytokines by brain endothelial cells: A polarized response to lipopolysaccharide, Brain Behav. Immun., 20, 449, 10.1016/j.bbi.2005.10.005

Weberpals, 2009, NOS2 gene deficiency protects from sepsis-induced long-term cognitive deficits, J. Neurosci., 29, 14177, 10.1523/JNEUROSCI.3238-09.2009

Wuchert, 2008, Rat area postrema microglial cells act as sensors for the toll-like receptor-4 agonist lipopolysaccharide, J. Neuroimmunol., 204, 66, 10.1016/j.jneuroim.2008.07.017

Xaio, 2001, Effect of LPS on the permeability of the blood–brain barrier to insulin, Brain Res., 896, 36, 10.1016/S0006-8993(00)03247-9

Zetterstrom, 1998, Delineation of the proinflammatory cytokine cascade in fever induction, Ann. N.Y. Acad. Sci., 856, 48, 10.1111/j.1749-6632.1998.tb08311.x

Zhao, 2007, Hematopoietic growth factors pass through the blood–brain barrier in intact rats, Exp. Neurol., 204, 569, 10.1016/j.expneurol.2006.12.001

Zlokovic, 2010, Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer’s amyloid beta-peptide elimination from the brain, J. Neurochem., 115, 1077, 10.1111/j.1471-4159.2010.07002.x