Cytokine, Sickness Behavior, and Depression

Immunology and Allergy Clinics of North America - Tập 29 Số 2 - Trang 247-264 - 2009
Robert Dantzer1
1Integrative Immunology and Behavior Program, University of Illinois at Urbana-Champaign, 212 ERML, 1201 W Gregory Drive, Urbana, IL 61801, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Dantzer, 2008, From inflammation to sickness and depression: when the immune system subjugates the brain, Nat Rev Neurosci, 9, 46, 10.1038/nrn2297

Konsman, 2002, Cytokine-induced sickness behaviour: mechanisms and implications, Trends Neurosci, 25, 154, 10.1016/S0166-2236(00)02088-9

Barton, 2003, Toll-like receptor signaling pathways, Science, 300, 1524, 10.1126/science.1085536

Romanovsky, 2005, Fever and hypothermia in systemic inflammation: recent discoveries and revisions, Front Biosci, 10, 2193, 10.2741/1690

Berkenbosch, 1987, Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1, Science, 238, 524, 10.1126/science.2443979

Ericsson, 1994, A functional anatomical analysis of central pathways subserving the effects of interleukin-1 on stress-related neuroendocrine neurons, J Neurosci, 14, 897, 10.1523/JNEUROSCI.14-02-00897.1994

Goehler, 1999, Interleukin-1beta in immune cells of the abdominal vagus nerve: a link between the immune and nervous systems?, J Neurosci, 19, 2799, 10.1523/JNEUROSCI.19-07-02799.1999

Ek, 1998, Activation of vagal afferents after intravenous injection of interleukin-1beta: role of endogenous prostaglandins, J Neurosci, 18, 9471, 10.1523/JNEUROSCI.18-22-09471.1998

Wan, 1994, Neural and biochemical mediators of endotoxin and stress-induced c-fos expression in the rat brain, Brain Res Bull, 34, 7, 10.1016/0361-9230(94)90179-1

Bluthe, 1994, Lipopolysaccharide induces sickness behaviour in rats by a vagal mediated mechanism, C R Acad Sci III, 317, 499

Bluthe, 1996, Vagotomy attenuates behavioural effects of interleukin-1 injected peripherally but not centrally, Neuroreport, 7, 1485, 10.1097/00001756-199606170-00008

Bluthe, 1996, Vagotomy blocks behavioural effects of interleukin-1 injected via the intraperitoneal route but not via other systemic routes, Neuroreport, 7, 2823, 10.1097/00001756-199611040-00083

Marvel, 2004, Reversible inactivation of the dorsal vagal complex blocks lipopolysaccharide-induced social withdrawal and c-Fos expression in central autonomic nuclei, Brain Behav Immun, 18, 123, 10.1016/j.bbi.2003.09.004

Romeo, 2003, Effects of glossopharyngeal nerve transection on central and peripheral cytokines and serum corticosterone induced by localized inflammation, J Neuroimmunol, 136, 104, 10.1016/S0165-5728(03)00033-X

Romeo, 2001, The glossopharyngeal nerve as a novel pathway in immune-to-brain communication: relevance to neuroimmune surveillance of the oral cavity, J Neuroimmunol, 115, 91, 10.1016/S0165-5728(01)00270-3

Konsman, 2000, The vagus nerve mediates behavioural depression, but not fever, in response to peripheral immune signals; a functional anatomical analysis, Eur J Neurosci, 12, 4434, 10.1046/j.0953-816X.2000.01319.x

Rivest, 2000, How the blood talks to the brain parenchyma and the paraventricular nucleus of the hypothalamus during systemic inflammatory and infectious stimuli, Proc Soc Exp Biol Med, 223, 22, 10.1046/j.1525-1373.2000.22304.x

Romanovsky, 2000, Thermoregulatory manifestations of systemic inflammation: lessons from vagotomy, Auton Neurosci, 85, 39, 10.1016/S1566-0702(00)00218-6

Laye, 2000, Endogenous brain IL-1 mediates LPS-induced anorexia and hypothalamic cytokine expression, Am J Physiol Regul Integr Comp Physiol, 279, R93, 10.1152/ajpregu.2000.279.1.R93

Kent, 1992, Different receptor mechanisms mediate the pyrogenic and behavioral effects of interleukin 1, Proc Natl Acad Sci USA, 89, 9117, 10.1073/pnas.89.19.9117

van Dam, 1992, Appearance of interleukin-1 in macrophages and in ramified microglia in the brain of endotoxin-treated rats: a pathway for the induction of non-specific symptoms of sickness?, Brain Res, 588, 291, 10.1016/0006-8993(92)91588-6

Konsman, 1999, Temporal and spatial relationships between lipopolysaccharide-induced expression of Fos, interleukin-1beta and inducible nitric oxide synthase in rat brain, Neuroscience, 89, 535, 10.1016/S0306-4522(98)00368-6

Ericsson, 1995, Type 1 interleukin-1 receptor in the rat brain: distribution, regulation, and relationship to sites of IL-1-induced cellular activation, J Comp Neurol, 361, 681, 10.1002/cne.903610410

Vitkovic, 2000, Cytokine signals propagate through the brain, Mol Psychiatry, 5, 604, 10.1038/sj.mp.4000813

Reyes, 2002, Involvement of the arcuate nucleus of the hypothalamus in interleukin-1-induced anorexia, J Neurosci, 22, 5091, 10.1523/JNEUROSCI.22-12-05091.2002

Laye, 1995, Subdiaphragmatic vagotomy blocks induction of IL-1 beta mRNA in mice brain in response to peripheral LPS, Am J Physiol, 268, R1327

Hansen, 2000, Effects of vagotomy on lipopolysaccharide-induced brain interleukin-1beta protein in rats, Auton Neurosci, 85, 119, 10.1016/S1566-0702(00)00230-7

Hosoi, 2000, Electrical stimulation of afferent vagus nerve induces IL-1beta expression in the brain and activates HPA axis, Am J Physiol Regul Integr Comp Physiol, 279, R141, 10.1152/ajpregu.2000.279.1.R141

Dantzer, 2000, Neural and humoral pathways of communication from the immune system to the brain: parallel or convergent?, Auton Neurosci, 85, 60

Dunn, 1999, Effects of cytokines on cerebral neurotransmission. Comparison with the effects of stress, Adv Exp Med Biol, 461, 117, 10.1007/978-0-585-37970-8_8

Anforth, 1998, Biological activity and brain actions of recombinant rat interleukin-1alpha and interleukin-1beta, Eur Cytokine Netw, 9, 279

Lenczowski, 1999, Central administration of rat IL-6 induces HPA activation and fever but not sickness behavior in rats, Am J Physiol, 276, R652

Bluthe, 2000, Role of IL-6 in cytokine-induced sickness behavior: a study with IL-6 deficient mice, Physiol Behav, 70, 367, 10.1016/S0031-9384(00)00269-9

Bluthe, 2000, Role of interleukin-1beta and tumour necrosis factor-alpha in lipopolysaccharide-induced sickness behaviour: a study with interleukin-1 type I receptor-deficient mice, Eur J Neurosci, 12, 4447

Konsman, 2000, Diffusion and action of intracerebroventricularly injected interleukin-1 in the CNS, Neuroscience, 101, 957, 10.1016/S0306-4522(00)00403-6

Burgess, 1998, Interleukin-1beta-converting enzyme-deficient mice resist central but not systemic endotoxin-induced anorexia, Am J Physiol, 274, R1829

Li, 2005, Modulation of Toll-interleukin 1 receptor mediated signaling, J Mol Med, 83, 258, 10.1007/s00109-004-0622-4

Cullinan, 1998, IL-1 receptor accessory protein is an essential component of the IL-1 receptor, J Immunol, 161, 5614, 10.4049/jimmunol.161.10.5614

French, 1999, Expression and localization of p80 and p68 interleukin-1 receptor proteins in the brain of adult mice, J Neuroimmunol, 93, 194, 10.1016/S0165-5728(98)00224-0

Katsuura, 1988, Identification of a high-affinity receptor for interleukin-1 beta in rat brain, Biochem Biophys Res Commun, 156, 61, 10.1016/S0006-291X(88)80805-2

Nishiyori, 1997, Type 2 interleukin-1 receptor mRNA is induced by kainic acid in the rat brain, Brain Res Mol Brain Res, 50, 237, 10.1016/S0169-328X(97)00195-2

Docagne, 2005, Differential regulation of type I and type II interleukin-1 receptors in focal brain inflammation, Eur J Neurosci, 21, 1205, 10.1111/j.1460-9568.2005.03965.x

Ilyin, 1996, In vivo regulation of the IL-1 beta system (ligand, receptors I and II, receptor accessory protein, and receptor antagonist) and TNF-alpha mRNAs in specific brain regions, Biochem Biophys Res Commun, 227, 861, 10.1006/bbrc.1996.1597

Takao, 1990, Interleukin-1 receptors in mouse brain: characterization and neuronal localization, Endocrinology, 127, 3070, 10.1210/endo-127-6-3070

Ban, 1991, Receptors for interleukin-1 (alpha and beta) in mouse brain: mapping and neuronal localization in hippocampus, Neuroscience, 43, 21, 10.1016/0306-4522(91)90412-H

Parnet, 1994, Expression of type I and type II interleukin-1 receptors in mouse brain, Brain Res Mol Brain Res, 27, 63, 10.1016/0169-328X(94)90185-6

Konsman, 2004, Rat brain vascular distribution of interleukin-1 type-1 receptor immunoreactivity: relationship to patterns of inducible cyclooxygenase expression by peripheral inflammatory stimuli, J Comp Neurol, 472, 113, 10.1002/cne.20052

Nadjar, 2003, Nuclear factor kappaB nuclear translocation as a crucial marker of brain response to interleukin-1. A study in rat and interleukin-1 type I deficient mouse, J Neurochem, 87, 1024, 10.1046/j.1471-4159.2003.02097.x

Gabellec, 1996, Interleukin-1 receptor accessory protein transcripts in the brain and spleen: kinetics after peripheral administration of bacterial lipopolysaccharide in mice, Neuroimmunomodulation, 3, 304, 10.1159/000097284

Liu, 1996, Rat homolog of mouse interleukin-1 receptor accessory protein: cloning, localization and modulation studies, J Neuroimmunol, 66, 41, 10.1016/0165-5728(96)00016-1

Cremona, 1998, Brain type I but not type II IL-1 receptors mediate the effects of IL-1 beta on behavior in mice, Am J Physiol, 274, R735

Sonti, 1997, Interleukin-1 (IL-1) receptor type I mediates anorexia but not adipsia induced by centrally administered IL-1beta, Physiol Behav, 62, 1179, 10.1016/S0031-9384(97)80019-4

Liege, 2000, Interleukin 1 receptor accessory protein (IL-1RAcP) is necessary for centrally mediated neuroendocrine and immune responses to IL-1beta, J Neuroimmunol, 110, 134, 10.1016/S0165-5728(00)00331-3

Quan, 1997, Induction of inhibitory factor kappaBalpha mRNA in the central nervous system after peripheral lipopolysaccharide administration: an in situ hybridization histochemistry study in the rat, Proc Natl Acad Sci USA, 94, 10985, 10.1073/pnas.94.20.10985

Kubota, 2000, Nuclear factor-kappaB inhibitor peptide inhibits spontaneous and interleukin-1beta-induced sleep, Am J Physiol Regul Integr Comp Physiol, 279, R404, 10.1152/ajpregu.2000.279.2.R404

Nadjar, 2005, Inactivation of the cerebral NFkappaB pathway inhibits interleukin-1beta-induced sickness behavior and c-Fos expression in various brain nuclei, Neuropsychopharmacology, 30, 1492, 10.1038/sj.npp.1300755

Kelly, 2003, Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1 beta on long term potentiation in rat dentate gyrus, J Biol Chem, 278, 19453, 10.1074/jbc.M301938200

Godbout, 2005, Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system, FASEB J, 19, 1329, 10.1096/fj.05-3776fje

O'Connor, 2005, IL-1beta-mediated innate immunity is amplified in the db/db mouse model of type 2 diabetes, J Immunol, 174, 4991, 10.4049/jimmunol.174.8.4991

Perry, 2004, The influence of systemic inflammation on inflammation in the brain: implications for chronic neurodegenerative disease, Brain Behav Immun, 18, 407, 10.1016/j.bbi.2004.01.004

Hart, 1988, Biological basis of the behavior of sick animals, Neurosci Biobehav Rev, 12, 123, 10.1016/S0149-7634(88)80004-6

Aubert, 1997, Differential effects of lipopolysaccharide on pup retrieving and nest building in lactating mice, Brain Behav Immun, 11, 107, 10.1006/brbi.1997.0485

Lutgendorf, 1999, Life stress, mood disturbance, and elevated interleukin-6 in healthy older women, J Gerontol A Biol Sci Med Sci, 54, M434, 10.1093/gerona/54.9.M434

Kiecolt-Glaser, 2002, Depression and immune function: central pathways to morbidity and mortality, J Psychosom Res, 53, 873, 10.1016/S0022-3999(02)00309-4

Alesci, 2005, Major depression is associated with significant diurnal elevations in plasma interleukin-6 levels, a shift of its circadian rhythm, and loss of physiological complexity in its secretion: clinical implications, J Clin Endocrinol Metab, 90, 2522, 10.1210/jc.2004-1667

Maes, 1995, Immunoendocrine aspects of major depression. Relationships between plasma interleukin-6 and soluble interleukin-2 receptor, prolactin and cortisol, Eur Arch Psychiatry Clin Neurosci, 245, 172, 10.1007/BF02193091

Maes, 1997, Increased serum IL-6 and IL-1 receptor antagonist concentrations in major depression and treatment resistant depression, Cytokines, 9, 853, 10.1006/cyto.1997.0238

Brambilla, 1998, Blood levels of cytokines in elderly patients with major depressive disorder, Acta Psychiatr Scand, 97, 309, 10.1111/j.1600-0447.1998.tb10005.x

Capuron, 2004, Baseline mood and psychosocial characteristics of patients developing depressive symptoms during interleukin-2 and/or interferon-alpha cancer therapy, Brain Behav Immun, 18, 205, 10.1016/j.bbi.2003.11.004

Capuron, 2002, Neurobehavioral effects of interferon-alpha in cancer patients: phenomenology and paroxetine responsiveness of symptom dimensions, Neuropsychopharmacology, 26, 643, 10.1016/S0893-133X(01)00407-9

Bull, 2008, Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-alpha and ribavirin treatment, Mol Psychiatry

Kraus, 2007, Serotonin-1A receptor gene HTR1A variation predicts interferon-induced depression in chronic hepatitis C, Gastroenterology, 132, 1279, 10.1053/j.gastro.2007.02.053

Capuron, 1999, Prediction of the depressive effects of interferon alfa therapy by the patient's initial affective state, N Engl J Med, 340, 1370, 10.1056/NEJM199904293401716

Miyaoka, 1999, Depression from interferon therapy in patients with hepatitis C, Am J Psychiatry, 156, 1120, 10.1176/ajp.156.7.1120

Capuron, 2003, Interferon-alpha-induced changes in tryptophan metabolism. Relationship to depression and paroxetine treatment, Biol Psychiatry, 54, 906, 10.1016/S0006-3223(03)00173-2

Constant, 2005, Mood alterations during interferon-alfa therapy in patients with chronic hepatitis C: evidence for an overlap between manic/hypomanic and depressive symptoms, J Clin Psychiatry, 66, 1050, 10.4088/JCP.v66n0814

Capuron, 2002, Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy, Mol Psychiatry, 7, 468, 10.1038/sj.mp.4000995

Maes, 2001, Treatment with interferon-alpha (IFN alpha) of hepatitis C patients induces lower serum dipeptidyl peptidase IV activity, which is related to IFN alpha-induced depressive and anxiety symptoms and immune activation, Mol Psychiatry, 6, 475, 10.1038/sj.mp.4000872

Lestage, 2002, The enzyme indoleamine 2,3-dioxygenase is induced in the mouse brain in response to peripheral administration of lipopolysaccharide and superantigen, Brain Behav Immun, 16, 596, 10.1016/S0889-1591(02)00014-4

Frenois, 2007, Lipopolysaccharide induces delayed FosB/DeltaFosB immunostaining within the mouse extended amygdala, hippocampus and hypothalamus, that parallel the expression of depressive-like behavior, Psychoneuroendocrinology, 32, 516, 10.1016/j.psyneuen.2007.03.005

Moreau, 2008, Inoculation of Bacillus Calmette-Guerin to mice induces an acute episode of sickness behavior followed by chronic depressive-like behavior, Brain Behav Immun, 22, 1087, 10.1016/j.bbi.2008.04.001

Andre, 2008, Spatio-temporal differences in the profile of murine brain expression of proinflammatory cytokines and indoleamine 2,3 dioxygenase in response to peripheral lipopolysaccharide administration, J Neuroimmunol, 200, 90, 10.1016/j.jneuroim.2008.06.011

O'Connor, 2008, Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3 dioxygenase activation in muce, Mol Psychiatry

Tyring, 2006, Etanercept and clinical outcomes, fatigue, and depression in psoriasis: double-blind placebo-controlled randomized phase III trial, Lancet, 367, 29, 10.1016/S0140-6736(05)67763-X

Schwarcz, 2002, Manipulation of brain kynurenines: glial targets, neuronal effects, and clinical opportunities, J Pharmacol Exp Ther, 303, 1, 10.1124/jpet.102.034439

Wichers, 2005, IDO and interferon-alpha-induced depressive symptoms: a shift in hypothesis from tryptophan depletion to neurotoxicity, Mol Psychiatry, 10, 538, 10.1038/sj.mp.4001600

Juengling, 2000, Prefrontal cortical hypometabolism during low-dose interferon alpha treatment, Psychopharmacology (Berl), 152, 383, 10.1007/s002130000549

Capuron, 2005, Brain metabolic changes and neurovegetative symptoms in medically ill patients undergoing interferon-alpha therapy, Abstr Soc Neurosci, 660, 23

Appels, 2000, Inflammation, depressive symptomatology, and coronary artery disease, Psychosom Med, 62, 601, 10.1097/00006842-200009000-00001

Lesperance, 2004, The association between major depression and levels of soluble intercellular adhesion molecule 1, interleukin-6, and C-reactive protein in patients with recent acute coronary syndromes, Am J Psychiatry, 161, 271, 10.1176/appi.ajp.161.2.271