Cystatin C and derived measures of renal function as risk factors for mortality and acute kidney injury in sepsis – A post-hoc analysis of the FINNAKI cohort

Journal of Critical Care - Tập 72 - Trang 154148 - 2022
Erik Linné1, Alma Elfström1, Anna Åkesson2, Jane Fisher3, Anders Grubb4, Ville Pettilä5, Suvi T. Vaara5, Adam Linder3, Peter Bentzer6
1Department of Anesthesiology and Intensive Care, Helsingborg Hospital, Helsingborg, Sweden
2Clinical Studies Sweden – Forum South, Skåne University Hospital, Lund, Sweden
3Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Division of Infection Medicine, Lund, Sweden
4Department of Clinical Chemistry, Skåne University Hospital, Lund University, Lund, Sweden
5Division of Intensive Care Medicine, Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
6Lund University, Helsingborg Hospital, Department of Clinical Sciences Lund Anesthesiology and Intensive Care, Lund, Sweden

Tài liệu tham khảo

Singer, 2016, The third international consensus definitions for Sepsis and septic shock (Sepsis-3), JAMA., 315, 801, 10.1001/jama.2016.0287 Rudd, 2020, Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the global burden of disease study, Lancet, 395, 200, 10.1016/S0140-6736(19)32989-7 Bellomo, 2017, Acute kidney injury in sepsis, Intensive Care Med, 43, 816, 10.1007/s00134-017-4755-7 Martensson, 2015, Sepsis-induced acute kidney injury, Crit Care Clin, 31, 649, 10.1016/j.ccc.2015.06.003 Singh, 2010, Chronic kidney disease: an inherent risk factor for acute kidney injury?, Clin J Am Soc Nephrol, 5, 1690, 10.2215/CJN.00830110 Nisula, 2013, Incidence, risk factors and 90-day mortality of patients with acute kidney injury in Finnish intensive care units: the FINNAKI study, Intensive Care Med, 39, 420, 10.1007/s00134-012-2796-5 Perinel, 2015, Transient and persistent acute kidney injury and the risk of hospital mortality in critically ill patients: results of a multicenter cohort study, Crit Care Med, 43, e269, 10.1097/CCM.0000000000001077 Singbartl, 2012, AKI in the ICU: definition, epidemiology, risk stratification, and outcomes, Kidney Int, 81, 819, 10.1038/ki.2011.339 Wald, 2012, Risk of chronic dialysis and death following acute kidney injury, Am J Med, 125, 585, 10.1016/j.amjmed.2012.01.016 Linder, 2014, Small acute increases in serum creatinine are associated with decreased long-term survival in the critically ill, Am J Respir Crit Care Med, 189, 1075, 10.1164/rccm.201311-2097OC Vinge, 1999, Relationships among serum cystatin C, serum creatinine, lean tissue mass and glomerular filtration rate in healthy adults, Scand J Clin Lab Invest, 59, 587, 10.1080/00365519950185076 Salgado, 2012, Cystatin C may better reflect the effect of obesity on renal function, Obesity (Silver Spring), 20, 1136, 10.1038/oby.2011.366 Friedman, 2010, Measuring the glomerular filtration rate in obese individuals without overt kidney disease, Nephron Clin Pract, 116, c224, 10.1159/000317203 Schück, 2004, Estimation of glomerular filtration rate in obese patients with chronic renal impairment based on serum cystatin C levels, Clin Nephrol, 62, 92, 10.5414/CNP62092 Odden, 2010, Age and cystatin C in healthy adults: a collaborative study, Nephrol Dial Transplant, 25, 463, 10.1093/ndt/gfp474 Jonsson, 2007, Estimated glomerular filtration rate (eGFRCystC) from serum cystatin C shows strong agreement with iohexol clearance in patients with low GFR, Scand J Clin Lab Invest, 67, 801, 10.1080/00365510701397538 Herget-Rosenthal, 2004, Early detection of acute renal failure by serum cystatin C, Kidney Int, 66, 1115, 10.1111/j.1523-1755.2004.00861.x Ferguson, 2015, Cystatin C as a biomarker for estimating glomerular filtration rate, Curr Opin Nephrol Hypertens, 24, 295, 10.1097/MNH.0000000000000115 Stevens, 2009, Factors other than glomerular filtration rate affect serum cystatin C levels, Kidney Int, 75, 652, 10.1038/ki.2008.638 Grubb, 2011, Cystatin C, a marker for successful aging and glomerular filtration rate, is not influenced by inflammation, Scand J Clin Lab Invest, 71, 145, 10.3109/00365513.2010.546879 Martensson, 2012, Impact of sepsis on levels of plasma cystatin C in AKI and non-AKI patients, Nephrol Dial Transplant, 27, 576, 10.1093/ndt/gfr358 Delanaye, 2014, Detection of decreased glomerular filtration rate in intensive care units: serum cystatin C versus serum creatinine, BMC Nephrol, 15, 9, 10.1186/1471-2369-15-9 Grubb, 2020, Shrunken pore syndrome - a common kidney disorder with high mortality. Diagnosis, prevalence, pathophysiology and treatment options, Clin Biochem, 83, 12, 10.1016/j.clinbiochem.2020.06.002 Risch, 2001, Effects of glucocorticoid immunosuppression on serum cystatin C concentrations in renal transplant patients, Clin Chem, 47, 2055, 10.1093/clinchem/47.11.2055 Williams, 2021, Time to eliminate health care disparities in the estimation of kidney function, N Engl J Med, 385, 1804, 10.1056/NEJMe2114918 Hsu, 2021, Race, genetic ancestry, and estimating kidney function in CKD, N Engl J Med, 385, 1750, 10.1056/NEJMoa2103753 Inker, 2021, New Creatinine- and Cystatin C-based equations to estimate GFR without race, N Engl J Med, 385, 1737, 10.1056/NEJMoa2102953 Shlipak, 2013, Cystatin C versus creatinine in determining risk based on kidney function, N Engl J Med, 369, 932, 10.1056/NEJMoa1214234 Peralta, 2011, Detection of chronic kidney disease with creatinine, cystatin C, and urine albumin-to-creatinine ratio and association with progression to end-stage renal disease and mortality, JAMA., 305, 1545, 10.1001/jama.2011.468 Willey, 2020, Creatinine versus cystatin C for renal function-based mortality prediction in an elderly cohort: the northern Manhattan study, PLoS One, 15, 10.1371/journal.pone.0226509 Dardashti, 2016, Shrunken pore syndrome is associated with a sharp rise in mortality in patients undergoing elective coronary artery bypass grafting, Scand J Clin Lab Invest, 76, 74, 10.3109/00365513.2015.1099724 Purde, 2016, The cystatin C/creatinine ratio, a marker of glomerular filtration quality: associated factors, reference intervals, and prediction of morbidity and mortality in healthy seniors, Transl Res, 169, e1 Grubb, 2021, Glomerular filtration and shrunken pore syndrome in children and adults, Acta Paediatr, 110, 2503, 10.1111/apa.15846 Grubb, 2015, Reduction in glomerular pore size is not restricted to pregnant women. Evidence for a new syndrome: ‘Shrunken pore syndrome’, Scand J Clin Lab Invest, 75, 333, 10.3109/00365513.2015.1025427 Ahlström, 2004, Evolution and predictive power of serum cystatin C in acute renal failure, Clin Nephrol, 62, 344, 10.5414/CNP62344 Bell, 2009, Cystatin C is correlated with mortality in patients with and without acute kidney injury, Nephrol Dial Transplant, 24, 3096, 10.1093/ndt/gfp196 Ravn, 2017, Superiority of serum Cystatin C over Creatinine in prediction of long-term prognosis at discharge from ICU, Crit Care Med, 45, 10.1097/CCM.0000000000002537 Jung, 2021, Creatinine-Cystatin C ratio and mortality in patients receiving intensive care and continuous kidney replacement therapy: a retrospective cohort study, Am J Kidney Dis, 77, 509, 10.1053/j.ajkd.2020.08.014 Levy, 2003, 2001 SCCM/ESICM/ACCP/ATS/SIS international Sepsis definitions conference, Crit Care Med, 31, 1250, 10.1097/01.CCM.0000050454.01978.3B 2012, Nephrology ISo. KDIGO clinical practice guideline for acute kidney injury, Kidney Int Suppl, 2 Levey, 1999, A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of diet in renal disease study group, Ann Intern Med, 130, 461, 10.7326/0003-4819-130-6-199903160-00002 Grubb, 2014, Generation of a new cystatin C-based estimating equation for glomerular filtration rate by use of 7 assays standardized to the international calibrator, Clin Chem, 60, 974, 10.1373/clinchem.2013.220707 Bjork, 2011, Revised equations for estimating glomerular filtration rate based on the Lund-Malmo study cohort, Scand J Clin Lab Invest, 71, 232, 10.3109/00365513.2011.557086 Bjork, 2015, Accuracy of GFR estimating equations combining standardized cystatin C and creatinine assays: a cross-sectional study in Sweden, Clin Chem Lab Med, 53, 403, 10.1515/cclm-2014-0578 Nyman, 2014, The revised Lund-Malmo GFR estimating equation outperforms MDRD and CKD-EPI across GFR, age and BMI intervals in a large Swedish population, Clin Chem Lab Med, 52, 815, 10.1515/cclm-2013-0741 Åkesson, 2020, Shrunken pore syndrome and mortality: a cohort study of patients with measured GFR and known comorbidities, Scand J Clin Lab Invest, 80, 412, 10.1080/00365513.2020.1759139 Tsushita, 2020, Effects of dose and type of corticosteroids on the divergence between estimated glomerular filtration rates derived from cystatin C and creatinine, J Clin Pharm Ther, 45, 1390, 10.1111/jcpt.13235 Grubb, 2017, Cystatin C is indispensable for evaluation of kidney disease, Ejifcc., 28, 268 Bagshaw, 2010, Cystatin C in acute kidney injury, Curr Opin Crit Care, 16, 533, 10.1097/MCC.0b013e32833e8412 Klein, 2018, Biomarkers for prediction of renal replacement therapy in acute kidney injury: a systematic review and meta-analysis, Intensive Care Med, 44, 323, 10.1007/s00134-018-5126-8 Shlipak, 2005, Cystatin C and the risk of death and cardiovascular events among elderly persons, N Engl J Med, 352, 2049, 10.1056/NEJMoa043161 Herou, 2019, The mortality increase in cardiac surgery patients associated with shrunken pore syndrome correlates with the eGFRcystatin C/eGFRcreatinine-ratio, Scand J Clin Lab Invest, 79, 167, 10.1080/00365513.2019.1576101 Almen, 2019, Shrunken pore syndrome is associated with increased levels of atherosclerosis-promoting proteins, Kidney Int Rep, 4, 67, 10.1016/j.ekir.2018.09.002 Öberg, 2021, Potential relationship between eGFRcystatin C/eGFRcreatinine-ratio and glomerular basement membrane thickness in diabetic kidney disease, Phys Rep, 9