Cystathionineβ-Synthase in Physiology and Cancer

BioMed Research International - Tập 2018 - Trang 1-11 - 2018
Haoran Zhu1,2, Shaun Blake1,2, Keefe T. Chan1, Richard B. Pearson3,4,1,2, Jian Kang1
1Division of Research, Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne, Victoria 3000, Australia
2Sir Peter MacCallum Department of Oncology, Australia
3Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3168, Australia
4Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria 3052, Australia

Tóm tắt

Cystathionineβ-synthase (CBS) regulates homocysteine metabolism and contributes to hydrogen sulfide (H2S) biosynthesis through which it plays multifunctional roles in the regulation of cellular energetics, redox status, DNA methylation, and protein modification. Inactivating mutations in CBS contribute to the pathogenesis of the autosomal recessive disease CBS-deficient homocystinuria. Recent studies demonstrating that CBS promotes colon and ovarian cancer growth in preclinical models highlight a newly identified oncogenic role for CBS. On the contrary, tumor-suppressive effects of CBS have been reported in other cancer types, suggesting context-dependent roles of CBS in tumor growth and progression. Here, we review the physiological functions of CBS, summarize the complexities regarding CBS research in oncology, and discuss the potential of CBS and its key metabolites, including homocysteine and H2S, as potential biomarkers for cancer diagnosis or therapeutic targets for cancer treatment.

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BioMed Research International

Tập 2018

1-11

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