Cyclosporine A promotes in vitro migration of human first-trimester trophoblasts via MAPK/ERK1/2-mediated NF-κB and Ca2+/calcineurin/NFAT signaling

Pringle, 2010, Beyond oxygen: complex regulation and activity of hypoxia inducible factors in pregnancy, Hum Reprod Update, 16, 415, 10.1093/humupd/dmp046 Guzeloglu-Kayisli, 2009, The role of growth factors and cytokines during implantation: endocrine and paracrine interactions, Semin Reprod Med, 27, 62, 10.1055/s-0028-1108011 Zhao, 2012, CXCL12/CXCR4 axis triggers the activation of EGF receptor and ERK signaling pathway in CsA-induced proliferation of human trophoblast cells, PLoS One, 7, e38375, 10.1371/journal.pone.0038375 Xie, 2010, NME1 at the human maternal-fetal interface downregulates titin expression and invasiveness of trophoblast cells via MAPK pathway in early pregnancy, Reproduction, 139, 799, 10.1530/REP-09-0490 Zhou, 2008, Chemokine CXCL12 promotes the cross-talk between trophoblasts and decidual stromal cells in human first-trimester pregnancy, Hum Reprod, 23, 2669, 10.1093/humrep/den308 Zhao, 2010, E-cadherin, as a negative regulator of invasive behavior of human trophoblast cells, is down-regulated by cyclosporin A via epidermal growth factor/extracellular signal-regulated protein kinase signaling pathway, Biol Reprod, 83, 370, 10.1095/biolreprod.110.083402 Zhou, 2007, Cyclosporin A promotes expression of matrix metalloproteinase 9 and 2 and invasiveness in vitro of the first-trimester human trophoblast cells via the mitogen-activated protein kinase pathway, Hum Reprod, 22, 2743, 10.1093/humrep/dem097 Du, 2012, Cyclosporin A promotes cross-talk between human cytotrophoblast and decidual stromal cell through upregulating CXCL12/CXCR4 interaction, Hum Reprod, 27, 1955, 10.1093/humrep/des111 Du, 2007, Cyclosporine A induces titin expression via MAPK/ERK signalling and improves proliferative and invasive potential of human trophoblast cells, Hum Reprod, 22, 2528, 10.1093/humrep/dem222 Du, 2007, Cyclosporin A improves pregnant outcome by promoting functions of trophoblasts and inducing maternal tolerance to the allogeneic fetus, Biol Reprod, 76, 906, 10.1095/biolreprod.106.056648 Du, 2008, Cyclosporin A promotes growth and invasiveness in vitro of human first-trimester trophoblast cells via MAPK3/MAPK1-mediated AP1 and Ca2+/calcineurin/NFAT signalling pathways, Biol Reprod, 78, 1102, 10.1095/biolreprod.107.063503 Di Donato, 2012, NF-κB and the link between inflammation and cancer, Immunol Rev, 246, 379, 10.1111/j.1600-065X.2012.01099.x Li, 2010, Tumor necrosis factor stimulates matrix metalloproteinase 9 secretion from cultured human chorionic trophoblast cells through TNF receptor 1 signaling to IKBKB-NFKB and MAPK1/3 pathway, Biol Reprod, 83, 481, 10.1095/biolreprod.109.082578 Marchand, 2011, Transcriptomic signature of trophoblast differentiation in a human embryonic stem cell model, Biol Reprod, 84, 1258, 10.1095/biolreprod.110.086413 Ross, 2010, Activation of the transcription factor, nuclear factor kappa-B, during the estrous cycle and early pregnancy in the pig, Reprod Biol Endocrinol, 8, 39, 10.1186/1477-7827-8-39 Di Simone, 2010, Antiphospholipid antibodies affect human endometrial angiogenesis, Biol Reprod, 83, 212, 10.1095/biolreprod.110.083410 Nakamura, 2004, NF kappaB activation at implantation window of the mouse uterus, Am J Reprod Immunol, 51, 16, 10.1046/j.8755-8920.2003.00116.x Tang, 2012, Focal adhesion kinase signaling is necessary for the cyclosporin A-enhanced migration and invasion of human trophoblast cells, Placenta, 33, 704, 10.1016/j.placenta.2012.06.007 Alvarez-Arroyo, 2002, Cyclophilin-mediated pathways in the effect of cyclosporin A on endothelial cells role of vascular endothelial growth factor, Circ Res, 91, 202, 10.1161/01.RES.0000027562.91075.56 Hojo, 1999, Cyclosporine induces cancer progression by a cell-autonomous mechanism, Nature, 397, 530, 10.1038/17401 Saba-El-Leil, 2003, An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development, EMBO Rep, 4, 964, 10.1038/sj.embor.embor939 Kita, 2003, Expression and activation of MAP kinases, ERK1/2, in the human villous trophoblasts, Placenta, 24, 164, 10.1053/plac.2002.0880 Huber, 2004, NF-kB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression, J Clin Invest, 114, 569, 10.1172/JCI200421358 Thiery, 2002, Epithelial-mesenchymal transitions in tumour progression, Nat Rev Cancer, 2, 442, 10.1038/nrc822 Thiery, 2003, Epithelial-mesenchymal transitions in development and pathologies, Curr Opin Cell Biol, 15, 740, 10.1016/j.ceb.2003.10.006 Finn, 1986, Implantation menstruation and inflammation, Biol Rev, 61, 313, 10.1111/j.1469-185X.1986.tb00657.x Kelly, 2001, Cytokine control in human endometrium, Reproduction, 121, 3, 10.1530/rep.0.1210003 Ferretti, 2007, Molecular circuits shared by placental and cancer cells, and their implications in the proliferative, invasive and migratory capacities of trophoblasts, Hum Reprod Update, 13, 121e41 Page, 2002, Expression of nuclear factor kappa B components in human endometrium, J Reprod Immunol, 54, 1, 10.1016/S0165-0378(01)00122-X Muggia, 1999, Trophoblast giant cells express NF-kappa B2 during early mouse development, Dev Genet, 25, 23, 10.1002/(SICI)1520-6408(1999)25:1<23::AID-DVG3>3.0.CO;2-K Bar Oz, 2001, Pregnancy outcome after cyclosporine therapy during pregnancy: a meta-analysis, Transplantation, 71, 1051, 10.1097/00007890-200104270-00006 Al Duraihimh, 2008, Outcome of 234 pregnancies in 140 renal transplant recipients from five middle eastern countries, Transplantation, 85, 840, 10.1097/TP.0b013e318166ac45 Armenti, 1997, Report from the National Transplantation Pregnancy Registry (NTPR): outcomes of pregnancy after transplantation, Clin Transplant, 101 Armenti, 1999, Report from the National Transplantation Pregnancy Registry (NTPR): outcomes of pregnancy after transplantation, Clin Transplant, 111 Coscia, 2010, Report from the National Transplantation Pregnancy registry (NTPR): outcomes of pregnancy after transplantation, Clin Transplant, 65 Cochat, 2004, Renal outcome of children exposed to cyclosporine in utero, Transplant Proc, 36, 208S, 10.1016/j.transproceed.2004.01.012 Sgro, 2002, Pregnancy outcome post renal transplantation, Teratology, 65, 5, 10.1002/tera.1092 Sivaraman, 2004, Management of pregnancy in transplant recipients, Transplant Proc, 36, 1999, 10.1016/j.transproceed.2004.08.029 Nulman, 2010, Long-term neurodevelopment of children exposed in utero to cyclosporin after maternal renal transplant, Paediatr Drugs, 12, 113, 10.2165/11316280-000000000-00000