Cyclosporine A inhibits breast cancer cell growth by downregulating the expression of pyruvate kinase subtype M2

Warburg, 1956, On the origin of cancer cells, Science, 123, 309, 10.1126/science.123.3191.309

Mazurek, 2005, Pyruvate kinase type M2 and its role in tumor growth and spreading, Semin Cancer Biol, 15, 300, 10.1016/j.semcancer.2005.04.009

Anastasiou, 2011, Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses, Science, 334, 1278, 10.1126/science.1211485

Goldberg, 2012, Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression, J Exp Med, 10.1084/jem.20111487

Yang, 2011, Nuclear PKM2 regulates beta-catenin transactivation upon EGFR activation, Nature, 480, 118, 10.1038/nature10598

Christofk, 2008, The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth, Nature, 452, 230, 10.1038/nature06734

Christofk, 2008, Pyruvate kinase M2 is a phosphotyrosine-binding protein, Nature, 452, 181, 10.1038/nature06667

Altenberg, 2004, Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes, Genomics, 84, 1014, 10.1016/j.ygeno.2004.08.010

Saeki, 1993, Human P-glycoprotein transports cyclosporin A and FK506, J Biol Chem, 268, 6077, 10.1016/S0021-9258(18)53221-X

Tan, 2000, Multidrug resistance transporters and modulation, Curr Opin Oncol, 12, 450, 10.1097/00001622-200009000-00011

Englund, 2004, Association between the number of coadministered P-glycoprotein inhibitors and serum digoxin levels in patients on therapeutic drug monitoring, BMC Med, 2, 8, 10.1186/1741-7015-2-8

Carcel-Trullols, 2004, Effect of cyclosporine A on the tissue distribution and pharmacokinetics of etoposide, Cancer Chemother Pharmacol, 54, 153, 10.1007/s00280-004-0784-3

Xia, 2007, Interactions of cyclosporin A with breast cancer resistance protein, Drug Metab Dispos, 35, 576, 10.1124/dmd.106.011866

Berthon, 1992, Characterization of normal breast epithelial cells in primary cultures: differentiation and growth factor receptors studies, In Vitro Cell Dev Biol, 28A, 716, 10.1007/BF02631059

Wang, 2008, Integrin beta 1 regulates phagosome maturation in macrophages through Rac expression, J Immunol, 180, 2419, 10.4049/jimmunol.180.4.2419

Liu, 2011, MicroRNA-98 negatively regulates IL-10 production and endotoxin tolerance in macrophages after LPS stimulation, FEBS Lett, 585, 1963, 10.1016/j.febslet.2011.05.029

Dombrauckas, 2005, Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis, Biochemistry, 44, 9417, 10.1021/bi0474923

Livak, 2001, Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method, Methods, 25, 402, 10.1006/meth.2001.1262

Larson, 2003, Bioluminescence ATP monitoring as a surrogate marker for microbial load on hands and surfaces in the home, Food Microbiol, 20, 735, 10.1016/S0740-0020(03)00041-8

Ishaque, 1998, Use of intracellular pH and annexin-V flow cytometric assays to monitor apoptosis and its suppression by bcl-2 over-expression in hybridoma cell culture, J Immunol Methods, 221, 43, 10.1016/S0022-1759(98)00166-5

Leist, 1997, Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis, J Exp Med, 185, 1481, 10.1084/jem.185.8.1481

Garber, 2006, Energy deregulation: licensing tumors to grow, Science, 312, 1158, 10.1126/science.312.5777.1158

Tani, 1988, Human M2-type pyruvate kinase: cDNA cloning, chromosomal assignment and expression in hepatoma, Gene, 73, 509, 10.1016/0378-1119(88)90515-X

Yamada, 1999, Regulation of pyruvate kinase M gene expression, Biochem Biophys Res Commun, 256, 257, 10.1006/bbrc.1999.0228

Li, 2012, Diagnostic value of fecal tumor M2-pyruvate kinase for CRC screening: A systematic review and meta-analysis, Int J Cancer, 10.1002/ijc.27442

Schneider, 2000, Comparison of the tumor markers tumor M2-PK, CEA, CYFRA 21-1, NSE and SCC in the diagnosis of lung cancer, Anticancer Res, 20, 5053

Schneider, 2003, Comparison of tumor M2-pyruvate kinase (tumor M2-PK), carcinoembryonic antigen (CEA), carbohydrate antigens CA 19-9 and CA 72-4 in the diagnosis of gastrointestinal cancer, Anticancer Res, 23, 5089

Buchholz, 2006, Overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway, EMBO J, 25, 3714, 10.1038/sj.emboj.7601246

Masuo, 2009, Cyclosporine A inhibits colorectal cancer proliferation probably by regulating expression levels of c-Myc, p21(WAF1/CIP1) and proliferating cell nuclear antigen, Cancer Lett, 285, 66, 10.1016/j.canlet.2009.05.001

Wooll, 2001, Structural and functional linkages between subunit interfaces in mammalian pyruvate kinase, J Mol Biol, 312, 525, 10.1006/jmbi.2001.4978

Gallimore, 2008, Regulatory T cells and tumour immunity - observations in mice and men, Immunology, 123, 157, 10.1111/j.1365-2567.2007.02748.x

Curiel, 2004, Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival, Nat Med, 10, 942, 10.1038/nm1093

Wu, 2006, FOXP3 controls regulatory T cell function through cooperation with NFAT, Cell, 126, 375, 10.1016/j.cell.2006.05.042